R E S E A R C H Open Access Nurse prescribing of medicines in 13 European countries Claudia B. Maier 1,2 Abstract Background: Nurse prescribing of medicines is increas ing worldwide, but there is limit ed research in Europe. The objective of this study was to analyse which countri es in Europe have adopted laws on nurse prescribing. Methods: Cross-country comparative analysis of reforms on nurse prescribing, based on an expert survey (TaskShift2Nurses Survey) and an OECD study. Country experts provid ed country-specific information, which was complemented with the peer-reviewed and grey literature. The analysis was based on policy and thematic analyses. Results: In Europe, as of 2019, a total of 13 countries have adopted laws on nurse prescribing, of which 12 apply nationwide (Cyprus, Denmark, Estonia, Finland, France, Ireland, Netherland s, Norway, Poland, Spain, Sweden, United Kingdom (UK)) and one regio nally, to the Canton Vaud (Switzerland). Eight countries adopted laws since 2010. The extent of prescribing rights ranged from nearly all medicin es within nurses ’ specialisations (Ireland for nurse prescribers, Netherlands for nurse specialists, UK for independent nurse pr escribers) to a limited set of medicines (Cyprus, Denmark, Estonia, Finland, France, Norway, Poland, Spain, Sweden). All countries have regulatory and minimum educational requireme nts in place to ensure patient safety; the majority require some form of physician oversight. Conclusions: The role of nurses has expanded in Europe over the last decade, as demonstrated by the adoption of new laws on prescribing rights. Keywords: Health professionals, Nurses, Prescribin g, Medications, Laws, Reforms, Advanced practice nursing (APN), Task shifting, Scope of practice Background The right to prescribe medications has for long been re- served to the medical professi on only. This situation has changed, with an increasing number of c ountries worldwide having introduced reform s to authorise nurses to prescribe certain medications [ 1 – 6 ]. The United States of America (US) and Canada have a long tr adition with nurses working in advanced practice roles, which includes the right to pre- scribe medicines [ 7 – 9 ]. Common drivers that led to nurse prescribing reforms include p hysic ian shortages (e.g. in rural areas), the rise in chron ic conditions, more interpro- fessional team work and an inc rease in nursing e ducation at higher educational institutions [ 1 , 3 , 10 ]. Introducing new roles for nurses has been referred to as a disruptive innovation in healthcare [ 11 ]. Advanced nursing roles have shown to have implications not only for the nurses and the teams in which they pra ctice and are influenced by policies and regulatory mechanisms [ 12 , 13 ]. For instance, changes to scope-of-practice la ws and policies on advanced educational programmes have shown to facilitate the up- take of nurse prescribing and o ther advanced practice nurs- ing roles [ 12 – 14 ]. Nurse prescribing refers to the official right gran ted to nurses to pres cribe certain medications [ 4 , 15 ]. The ex- tent of nurse prescribing depen ds on several factors: first, the groups of nurse s authorised to prescr ibe, which can range from small, highly specialised groups of nurses to all professi onal nurses; second, the type of medica- tions that nurses are allowe d to prescribe, which can range from all medicines to a restricted set; and third, the overall legal responsibility, ranging from independent © The Author(s). 2019 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License ( http://creativecommons. org/licenses/by/4.0/ ), which permits unrestricted use, distribution , and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain De dication waiver ( http://creativecommons.org/publicdomain/zero/1.0/ ) applies to the data made available in this article, unless otherwise stated. Correspondence: c.maier@tu-ber lin.de ; [email protected] 1 Department of Healthcare Management, Technische Un iversität Berlin H 80, Straße des 17. Juni 135, 10623 Berlin, Germany 2 Center for Health Outcomes and Policy Research, University of Pennsylvania School of Nursing, Claire Fagin Hall, 418 Curie Blvd, Philadelphia, PA 19104, United States of America Maier Human Resources for Health (2019) 17:95 https://doi.org/10.1186/s12960-019- 0429-6 prescribing to a delegated model under the supervision of a physician [ 15 – 17 ]. Nurse prescribing has been shown to be comparable to physici ans ’ prescribing prac- tices, as measured by the number of medic ations pre- scribed as well as the types and dose s of the medic ations chosen [ 6 , 18 , 19 ]. Patients wer e similarly satisfi ed or more satisfied with nurses than phy sicians [ 18 ]. A Cochrane syste matic review showed tha t nurses were as effective in prescribing medicat ions as physicians for a range of conditio ns including chronic dise ases [ 19 ]. An international survey in ten high-in come countries (Australia, Can ada, Finland, Ireland, the Netherlands, New Zealand, Spain, Swede n, the United Kingdom and the US) showed that the educational and legal condi- tions varied across countries [ 1 ]. Among high-income countries worldw ide, Australi a, Canada, New Zea land and the US are commonly cited as having impleme nted laws granting the prescr ibing of a wide range of medi- cines to advanced practice nur ses (APN) with a Master ’ s degree [ 1 , 2 ]. APN in these countries are authorised to prescribe all or almost all medici nes within their spe- cialty. How ever, differences exist in the regulat ion of nurse prescribing, nam ely if collaborative agree ments with physicians are require d by law [ 6 , 20 , 21 ]. In addition, in Australia, Canada and New Zealan d, there have also been recent deve lopments to grant registered nurses limit ed prescribing rights [ 21 , 22 ]. In Europe, the United Kingdom (UK) has a long ex- perience with nurse prescr ibing [ 6 ], where two models of nurse prescr ibing originated [ 15 , 23 ], inde pendent and supplementa ry nurse prescribing. While the forme r model grants the nurses the authority to issu e prescrip- tions independently including initial prescribing of a medicine for the first time, the latter model refers to the continued prescr ibing after a diagnosis and treatment plan has been made by a physician [ 15 , 23 ]. Rese arch on nurse prescribing reforms has been limited and mostly focused on selected topics and indiv idual countries, such as in the UK and Ireland on prescribing practic es and safety considerations [ 24 , 25 ] as well as factor s enabling implementation of reforms in Ireland [ 26 ]. Recently, re- search in the Netherlands has evalu ated task shifting be- tween physic ians and nurse specialists with gener ally positive results [ 27 , 28 ]. Research in the Netherlands also assessed physician s ’ and nurses ’ views of introdu- cing nurse prescribing [ 23 ] as well as prescr ibing prac- tices of nurses in hospit als, which were show n to be influenced by national policies as well as individual hos- pital governan ce structures [ 29 ]. From an intern ational, cross-country pers pective, research on nurse prescribing reforms and the extent of pres cribing authority of medi- cines has bee n scarce. One exception is a revie w by Kroezen et al. [ 1 ]. The review covered 10 coun tries of which six belong to the Europe an Union (Finland, Ireland, the Nethe rlands, Spain, Sweden, and the Unite d Kingdom). It show ed that at the time of data collection, three countrie s (Finland, Spain, the Ne therlands) were in the process of introducing legislation , suggesting an up- date of the current state of these reforms is warran ted. Moreover, no study to date has systematic ally covered all countries belongi ng to the EU ’ s single market. The pu rp os e o f th is st ud y wa s to an al ys e whi ch co un - tri es in Eu ro pe have i ntro du ce d nu rse pr es cr ibi ng re fo rm s, the ex te nt of pres cr ib ing an d regu la tio ns in plac e. Co v er- ing al l coun tr ies b elon gi ng to th e EU ’ ss i n g l em a r k e t i so f re leva nc e for its fr ee mo ve me nt pr in ci ple ac ro ss bor de rs wh ich also ap pl ies to he al th prof e ssi on al s. For the nu rs in g pro fe ssi on , the fi rs t- lev el ed uc at ion as pr of es si on al nu rs e is auto ma ti ca lly re co gn ise d, ye t no nurs e spec ia lis at i ons ar e cover ed un de r the EU re gu lati o n [ 30 , 31 ]. Methods The study was based on an expert survey to identify which countrie s in Europe have implemented reforms on nurse prescr ibing of medicines and, in those coun - tries with reforms, an analy sis of the extent of prescrib- ing authority, regulatory and ove rsight requirements. Expert survey to identify countr ies with prescribing reforms An expert survey was conducted in 39 countries (Task- Shift2Nurses Study) in 2015 covering all EU Member States and countries belonging to the EU ’ ss i n g l em a r - ket, pl us Aust rali a, Canad a, New Zeal and an d the US. A total of 93 country expe rts participated (response rate 85.3%). The s ampling was based on two interre- lated strategies: snowballing and ne two rk strategies to counteract the weaknesses as sociated with snowballing alone, which has been associated with selection bias or too homogeneo us groups [ 2 ]. The selection process of the country experts followed two stages: first, five i nter- national health workforce experts were identified and contacted to provide names of country experts. In a second step, the suggested names were reviewed and contacted if in accordance with a list of pre-defined cri- teria (e.g. senior position related to nursing either in academia, at national nursing association, Ministry of Health, relevant publications on the topic, proficiency in Engli sh). More details about the method ology are available elsewhere [ 2 ]. Among the questions covered i nt h es u r v e yw e r ei fn u r s e sw e r ea u t h o r i s e dt op r e - scribe medications and related reforms implemented or ongoing, as of 2015. Analysis of country reforms on nurse prescribing Of those countries identified with reforms on nurse pre- scribing, an in-dept h analysis of laws and policy documents was performed as pa rt of an Organisation for E conomic Maier Human Resources for Health (2019) 17:95 Page 2 of 10 Cooperation and Developmen t( O E C D )s t u d y .C o u n t r ye x - perts were contacted in 2016 for the purpose of the OECD study on nurses in adva nced ro les of which prescribing of medicines was one example [ 4 ]. A total of 25 country ex- p e r t sf r o mt h o s ec o u n t r i e sw i t h nurse prescribing reforms implemented or ongoing were contacted and 21 partici- pated (response rate 84%). They provided additional infor- mation on the laws, the extent of pr escribing rights (e.g. for which medi cines and health condit ions), e ducation al, reg u- latory and oversi ght requirem ents in the countries. For the purpose of th is paper , the countr y experts we re again co n- tacted in 2019 to inquire if the information provided in 2016 was still up to date. A total of 15 experts participated in the 2019 round (response rate 60%) and provided up- dates to pre-filled forms based on the 2016 data collection. In five cases, there was a lack of clarity on specific issues, which was then followed up via e-mail or phone calls and resolved through discussion. In addition, a literature search was conduc ted with a search of the peer-reviewe d (PubMed, CINAH L, Google Scholar) and grey literatu re (websites of Internatio nal Council of Nur ses, European Federa tion of Nurses, WHO, OECD, natio nal Ministries of Health). Search terms covered a set of terms combined with Boolean op- erators on nur ses (e.g. registered nurse , professional nurse, nurse speciali st, Advanced Prac tice Nurse, Nurse Practitioner and other titles and combinations), prescrib- ing (prescri*) and the nam es of the 28 EU countries plus Norway and Switzerland. The an al ys is wa s b ased on them ati c analys es of th e laws , poli cy docu ment s and othe r grey ma teri al, focu ssi ng on the co nten t of the la ws, by- laws an d the educ ati onal an d re gul atory re quir ements if stip ulat ed in oth er lega l docu - ment s. The anal yses we re stru ctured ac cord ing to the gro ups of nurs es auth oris ed to pres cribe , by medici nes us ed for th e prev enti on or trea tment of ma jor cond itio ns to asse ss the exte nt of prescr ibin g, diff eren tiat ing betw een ini tial pr escr ibing (I P) and conti nued pr escr ibing (C P) onl y. Fina lly, addi tion al requ ireme nts we re anal ysed by coun try an d grou ps of nurses , incl uding ma ndato ry regis- tra tion r equi reme nts ( e.g. in a r egistr y), l evel s of physi cian ov ersi ght and ot her ove rsigh t requ iremen ts. Th e an alys is was pe rfor med by th e auth or using stan dard ised wo rd ta- bles ba sed on the surv ey resp onses, co mple mente d wi th inf orma tion fr om the la ws an d legal do cume nts an d fed back to the co untr y expe rts as part of th e 2019 ro und wh ere ex pert s were re ques ted to pr ovide up date s of the inf orma tion or conf irm th at th e inf orma tion wa s up to da te. Results As of 2019, 13 countries in Europe have laws on nurse prescribing in place, which apply nationwide in 12 countries (Cyprus, Denmark, Estonia, Finland, France, Ireland, Netherlands, Norway, Poland, Spain, Sweden, United Kingdom) and in one regi on in Switzerland in the Canton Vaud (Table 1 ). The four nations of the UK an d Sweden were the first countries in Europe which introduced pres cribing rights dating back to 1992 and 1994, res pectively. Countries that followe d were Norway, Ireland and Den mark in 2002, 2007 and 2009. Since 2010, eight additional coun- tries (including the Canton Vaud, Switze rland) have authorised specific groups of nurses to prescribe certain medications. All have adopt ed laws to officiall y grant nurses prescribing rights , in some case s followed by the adoption of decre es to define und er which conditio ns nurses are allowe d prescribe, for what medic ations and the regulatory requiremen ts. The countries vary conside rably in the groups of nurses tha t are authorised to prescr ibe and their educa- tional requirement s: a first group consists of countries in which the prescribing skills and competencies are part of the nurses ’ education, e.g. Master ’ s or Bachelor ’ s de- grees or specific nur se specialisations . Hence, the pre- scribing skills and competencies are directly integra ted in these curricula, e.g. ANP Master nurses in Cyprus, Nurse Specialists with APN degree in the Ne therlands, Public Health Nurses in Norway, nurses with Master ’ s and Bachelor ’ s degree in Poland, family nur ses in Estonia; and nurses with a Bachel or ’ s degree in Spain. Since courses on pha rmacology and pharmaco therapy are routinely part of these curricul a, it was only in a few cases possible to single out how many Europe an Credit Transfer System s (ECTS) points are allocated spe cifically on skills and compe tencies related to the prescr ibing of medicines. For instance , in Cyprus, the curriculum of APN Master-le vel nurses comprises advanced pharma- cology and pharmacothera py of approx. six ECTS. In Denmark, prescr ibing is taught as part of a 30 ECT S “ cluster ” on medical treatm ent and therapy. In the Netherlands, RNs with a specialisation in diabetes and RNs with a specialisation of lung care are required to have a minimum of 2.5 ECTS on prescribing in their curriculum [ 32 ]. Second, some countries have set up a separate edu ca- tional pathway spe cifically on nurse prescribing, hence, additional educational cour ses which lead to a title as nurse prescriber or similar. The countries are Finland, Ireland and the UK. Th e UK has introduced two models of prescribing, independent and supplementary pre- scribers. Irelan d and Finland have established one role. Educational require ments vary, they range between typically 30 to 45 UK credits in the UK, 20 to 40 ECTS in Ireland and mandatory 45 ECTS in Finland. In 2019, the UK Nursin g and Midwifery Counc il has published new standards for the po st-registration pro grammes which apply since Septe mber 2019 [ 46 ]. Maier Human Resources for Health (2019) 17:95 Page 3 of 10 France and the Swiss Canton Vaud are in the process of implementing the 2017 laws on nur se prescribing, pending the agree ment of formularies and othe r mini- mum requirements as a prerequisite for nur ses to offi- cially being authorised to prescribe medicines. Extent of prescribing rights Table 2 shows the exten t of prescribing rights by coun- try. The countries vary considerably in the number of medicines which nurses are officially allowed to pre- scribe, for which dise ases and the type of prescribing. The type of prescribing refers to initial and continued prescribing, of which the former is the right to newly prescribe medic ines, whereas the latter refer s to follow- up prescriptions after the diagno sis and first pres cription has been issued by a physician . Thre e of th e 13 co untr ies ha ve gran ted fu ll or near ly fu ll pres crib ing ri ghts to a sp ecifi c gro up of nurs es. Th e coun - tri es are Ir elan d (nur se pres cribe rs), th e Neth erla nds (n urse spec iali sts) an d the UK (i ndep ende nt nurs e pre- scri bers ). Thes e groups o f nurs es are by law al lowe d to pres crib e any me dici ne with in thei r spec ialty . In the U K and Ir elan d, the exte nt of presc ribi ng was expa nded gr ad- uall y over time . In the UK , the l aw was ch ange d in 20 06 auth ori sing inde pend ent pre scri bers full ac cess to th e Brit- ish Na tional F ormula ry gran ting the same pr escr ibin g righ ts as for phys ician s, and subs equent ly in 2012 to cov er cert ain co ntro lled drug s [ 16 ]. In Ir elan d, nurs e pr escri bers can pr escr ibe a full se t of med icine s sinc e 2007 , inclu ding cert ain co ntro lled drug s. In the Ne therla nds, an i niti all y time -li mited la w was int rodu ced in 20 12, lin ked to a na- tio nwide eval uatio n. The l aw gran ted nu rse sp ecia lis ts with a Ma ster ’ s degree AP N full pr escr ibi ng righ ts withi n Table 1 Nurse prescribing laws, years of adoption and groups of nurses authorised to prescribe medications, 13 countries Year first adopted Country Regulation Group(s) of nurses authorised to prescribe (qualification requirements) 1992 UK Medicinal Products: Prescription by Nurses etc. Act 1992 (i) Independent prescribers (full prescribing rights since 2006; including certain controlled drugs since 2012, course on independent nurse prescribing required (NMC approved post-registration prescribing programme e.g. v200 or v300 course, length varies, e.g. 30 – 45 UK credits, typically 6 months; as of September 2019, new standards apply), this includes Community Practitioner Nurse Pre- scribers (CPNP) with prescribing rights according to a formulary (e.g. V100 or V150, e.g. 10 UK credits), (ii) Supplementary prescribers since 1992 (limited pre- scribing rights, approved course as a supplementary prescriber) 1994 Sweden Law RN (Bachelor from university or university college, 180 ECTS) 2002 Norway Law Public health nurse specialisation (Bachelor, plus 60 ECTS) 2007 Ireland Pharmacy Act, Statutory Instrument No. 201/2007 on Medicinal Products Nurse prescriber: RN plus additional, approve d educational programme (range 20 to 40 ECTS for nurse prescriber certificate or higher if Master APN programme) 2009 Denmark Order 1219 of 11/12/2009 delegation of reserved procedures RN (Bachelor, of which 30 ECTS “ cluster ” on medical treatment, including prescribing) 2010 Finland Decree 1088/2010 on Prescriptions Nurse prescriber: RN (Bachelor, with postgraduate education in prescribing (45 ECTS) 2012 Netherlands Decree, December 21/2011 Nurse specialist ( Verpleegkundig Specialist ) (Master APN, 120 ECTS) 2012 Cyprus Nursing and Midwifery Law, Annex III, 2b) V APN nurse (Master APN degree with specialisation in Midwifery, ICU, Mental Health, Oncology, Community health). Advanced pharmacology (6 ECTS) is part of the Master APN programme 2014 Netherlands Decree of 2014 Diabetes, lung, oncolog y nurses (Bachelor, and completion of pharmacothe rapy course at a University of Applied Science, e.g. for diabetes and lung nurses, curricula comprise minimum of 2.5 ECTS on prescribing 2015 Poland Ordinance of 28/10/2015 on prescriptions issued by nurses and midwives Two-tiered: RN with (i) Master and (ii) Bachelor ’ s degree 2015 Spain Royal Decree 954/201 5 of 23 October RN (Bachelor with min. 1 year work experie nce; or additional training in prescribing if < 1 year experience) 2016 Estonia Health Services Organization Act 2016 Family nurse ( pereõde ) if working with a family doctor ( pereast ) with completed training of 120 hours (clinical pharmacology, approved by the Agency of Medicines) 2017 France Act 2016-41 on the modernisation of the health system Nurse ( “ Medical auxillaires ” ) 2017 Switzerland (Vaud) Article 124b of Public Health Act 800.01 Nurse specialist (Master) ( “ Infirmier practicien spécialisé ” ) ANP advanced nursing prac tice, APN advanced practice nurse, CPD continuous professional develop ment, RN registered nurse, sources: [ 16 , 32 – 45 ] Maier Human Resources for Health (2019) 17:95 Page 4 of 10 thei r spec ialty . Afte r a gene rall y posi tive ev alua tion, th e time -li mited na ture o f the law wa s chan ged to un limi ted dura tio n in Sept embe r 20 18 [ 27 ]. In th e rema inder coun trie s, th e exte nt of pr escri bing is limi ted, ei ther in the numb er of medi cines that nu rses ar e by law al low ed to pr escri be or in the ty pe of pres crib ing, al lowing pr ima ril y or excl usive ly cont inued pr escr ibing . In the Net herl ands (Bac helo r nurses wi th a spec iali sati on in ei ther diab etes , lun g or oncolo gy), No rway (pub lic he alth nurs es), Po land (M aste r lev el) and Sw eden (Bac hel or le vel), nu rses ar e autho rise d to in itial ly pres crib e cert ain medi cine s from a l imite d set of me dici nes (Tab le 2 ). In the Neth erla nd s, th e thre e Bachel or-l evel nurs e spec ialis a- tio ns are auth oris ed to initi ally pr escri be a limit ed numbe r of med icine s with in their sp ecia lty (p resc ript ion- only medi cati ons) , afte r a di agno sis has be en made b y a phys- ic ian, an d as spec ified withi n prot ocol s and st anda rds. In Norw ay, publ ic heal th nurs es work in chi ld heal th clin ics and fr equent ly in scho ols or yout h health c entr es wher e they pr ovi de heal th counse llin g incl udi ng on sexu al health and pr escr ibe cont race ptive s [ 47 ]. Pu blic he alth nu rses can of fici all y prescr ibe al l contr acep tive s for al l wome n Table 2 Extent of nurse prescribing, by group(s) of nurses and country Prescribing rights by major areas and conditions (IP = initial prescribing, CP = continued prescribing only) Country Name/title of nurses Vaccines Contraceptives Chronic conditions Acute illnesses Pain medication Other Full prescribing rights (within specialty) Ireland Nurse prescriber 1 IP IP IP IP IP IP Netherlands Nurse Specialist 2 IP IP IP IP IP IP UK Independent prescriber 1 IP IP IP IP IP IP Limited prescribing rights Denmark Registered Nurse 3 CP CP CP CP CP CP Estonia Family nurse ( pereõde ) – CP (hormonal contraceptive) CP (diabetes, hypertension) CP (acute cystitis, nitrofurantoiin) –– Finland Nurse prescriber IP (influenza, hep., varicella^) IP (hormonal contraceptive^#) CP (asthma, dyslipidemia, T2D, hypertension)^ IP (pharyngitis)^, CP (UTI)^ IP (e.g. local anaesthetics)^ – Netherlands Diabetes, lung, oncology nurses –– IP (diabetes, oncology, lung diseases) – IP (oncology) – Norway Public Health Nurse IP IP (including IUD) a –– IP (adrenaline for allergic reaction, local anaesthetics) IP (sterile equipment for IU, implants, STD kits) Poland RN (Master) – IP (gynaecological drugs) IP (asthma, e.g. bronchodilators) IP (throat, ear, sinus, UTI) IP (analgesics, locally acting anaesthetics) IP (anti-emetics, anti-parasitic, IV infusion fluids) Poland RN (Bachelor) 4 – CP (as above) CP (as above) CP (as above) CP (as above) CP (as above) Spain RN (Bachelor) 5 IP (according to vaccination schedule) IP (emergency contraception) CP CP CP IP (OTC) Sweden RN (Bachelor) –– – IP (throat, mouth, dermatological disease, GI, UTI) IP (pain management) – UK Supplementary prescriber CP CP CP CP CP CP Cyprus, France, Switzer land (Vaud): not listed because no information availabl e on the medicines/formulary, IP initial prescribing (prescribing right of a new medicine/product), CP continuous prescrib ing (follow-up prescribing after first pres cription issued by physician), n/r not reported (in the law/regulations, “ - “ not authorised to prescrib e any medicine/produc t in the area, n/a no information availab le, OTC over-the-counter medic ines, Hep . hepatitis, UTI urinary tract infection, GI grastrointestinal. 1 Initial prescribing rights of all medici nes falling within nurses ’ specialty, restricti ons and additional require ments apply to contro lled drugs (e.g. UK: controlled drugs except for cocai ne, dipipanone or diamorphine for treating addiction ), 2 Netherlands = initial prescribing rights of all medicines falling within nurses withi n nurse specialists ’ speci alty, Cyprus = details on the types of medicines/subs tances not (yet) specified in law; ^not for children under the age of 12, #not for women under age 35, a only for women over 16 years of age, 3 Denmark = continued prescribing accord ing to local frame prescriptions and in a delegated model, 4 Poland: prescribing rights accord ing to formulary of 12 groups of m edicines, 5 Spain: prescribing rights granted to all RN with minimum 1 year work experience; for RN with less than 1 year work experi ence, additional training required Maier Human Resources for Health (2019) 17:95 Page 5 of 10 ag ed 16 year s and over. In o ne stud y, publi c heal th nurses wro te more pres cri ption s than ph ysi cians f or youn g wome n aged 17 – 18 years [ 47 ]. A mix of initial and contin ued prescribing ex ists in Finland and Spain; it includes initi al prescriptions of vac- cines and contraceptives in F inland and Spa in and follow- up medications for highly prevalent chronic and acute c on- ditions. In Denmark (Bachelor), Estonia (family nurse), Poland (Bachelor) and the UK (supplementary pre scribers), nurses are authorised to perfo rm continued prescribing, ac- cording to patient management plans and in a delegated model. No information on the details of prescribing rights was identified for Cypru s, France and the Canton Vaud (Switzerland). In Cyprus, there is no information pro- vided in the 2012 law on what medicines the Master APN nurses are allowed to prescr ibe. The law sta tes that medicines from a list can be prescribed by nurses, but with no furthe r information. In Fr ance and Vaud, due to the adoption of the laws in 2017, developments are on- going to specify which medic ations nurses will be able to prescribe. Regulatory and oversight requir ements All countries have define d regulatory requirements as a pre-condition for nurses to prescribe medic ations (Table 3 ). The reason is the highly specialise d nature of prescribing. The majo rity of countries requi re some form of additional registratio n as a prescriber in a regis- try or a prior authorisation by a competent authority . Several countries added additional regu latory require- ments, e.g. in Ireland, UK and Finland, nurse prescribers receive a uniq ue ID number to facilita te the identifi ca- tion of who prescribes what medic ation. In addition, most countrie s require some form of official authorisa - tion, contract, collaboration, agree ment or offi cial super- vision by an individual physician (Denmark, Estonia, Finland, Ireland, Spain , UK). Discussion This study show s that in Europe, certa in groups of nurses are offi cially authorised to prescribe medications in 13 countries (nation wide in 12 countries and in one region in Swi tzerland, Canton Vaud). Th e majority of the reforms have been introduced over the past decad e. Since 2010 alon e, eight of the 13 countrie s newly intro- duced nurse prescribing (Finland, Netherlands , Cyprus, Estonia, Poland , Spain, France and the region Vaud in Switzerland). Hence, nur se prescribing has been a recent development in several countrie s in Europe. The ext ent of prescribing rights varies considerably, with three countries (Irel and, Netherlands, UK) grantin g certain groups of nurse s (nurse prescri bers, nurse specia lists, in- dependent nurse pres cribers, respectively) almost full prescribing authority within their specialty. In the other countries, the number of medicat ions is restricted, de- fined in a formu lary or can be prescribed only after an initial prescription has been made by a phy sician. All countries have regul ated the conditions under which nurses are allowed to prescribe; the majority require additional registra tion in the prescribing func tion, some form of physician ove rsight and other mea sures to en- sure patien t safety. The study face s several limitation s. First, it has exclu- sively focused on nurse prescribing; howe ver, some of the countrie s have also introd uced prescribing for other non-medical professio ns, such as midwives or pha rma- cists. Second, while the article prov ides an overview of the groups of nurses and ext ent of prescribing rights, the exact types and dose s of medicines were not covered in- depth and should be investigated in future research. Third, information on educa tional requirements for nurse prescri bing was difficult to obtain, parti cularly for countries where nurse prescribing is integra ted in basic or advanced educatio nal programmes. The fi ndin gs are la rgel y cons isten t with pr eviou s re- sear ch [ 1 , 3 , 4 ] and pro vi de an upda te with mor e Euro pean co untr ies cover ed and rece nt reform s incl uded. Whi le seve ral stud ies in the pa st have fo cuse d on Angl o- Saxo n coun trie s, with Irel and an d the UK f requ entl y cov- er ed in rese arch [ 10 , 15 ], this st udy has en abl ed to cove r more E uropea n countr ies. Th is stud y sh ows that the ex- tent of nu rse pres cribi ng vari es cons ider abl y acro ss the coun trie s stud ied an d for sp ecifi c group s of nurs es wi thin thre e coun tri es (Net herlan ds, Po land , UK), wh ich is con- sist ent wi th th e prev ious lit erat ure (i bid) . Most co untr ies in thi s stud y rest ricted pr escr ibing ri ghts to a li st of medi - ci nes with re gulat ory requ irem ents inc ludi ng phys ician ov ersi ght. In pr eviou s rese arch , du e to the diff eren ces in coun try co verag e, whic h covere d six Eu ropean coun tries (Fin la nd, I re land , Net he rlan ds , Spa in, S we den, UK ) a nd Aust rali a, Cana da, New Zea land an d th e Un ited Sta tes, the f indi ngs sho wed high er lev els pr escr ibing ri ghts and inde pend ence in pr escri bing , e.g. for adva nced pr acti ce nurs es [ 1 , 17 ]. The findings of this study show that the re are high variations in the educational requirements, rangin g from Bachelor level (e.g. Denmark, Spain, Sweden) to Master level degrees (e.g . Cyprus, Netherlands, Poland ). There was no obvious link betw een the extent of prescr ibing rights and the length and level of training across the countries. In the three countries with almo st full pre- scribing rights, educational requirement s also varied. In the Netherlands, nurse specialists are require d to hold a Master ’ s degree (120 ECTS) as a prer equisite to pre- scribe medicines. In Ireland and the UK, the competen- cies are taught in prescriber course s that are approved by the competent authoritie s, but the length varies and a Maier Human Resources for Health (2019) 17:95 Page 6 of 10 Master ’ s degree is not require d. There is a paucity of re- search link ing the educational requirement s with pre- scribing practic es, the quality of pres cribing and patien t outcomes. While previous research has analysed the as- sociation of higher nurse edu cation (e.g. higher propor- tion of Bachelor-level nurses or a higher proportion of professional nurse s among all nur ses) with improv ed pa- tient outcomes and mor tality [ 48 , 49 ], no resea rch was identified on the asso ciation between qualification and prescribing outcomes. The reforms introducin g nurse prescribing in 13 countries span different health systems, educational systems and geographic lo cations across Europe, in- cluding predominantly soci al health insurance (France, Netherlands) and Beveridge models (e.g. UK, Ireland). The reasons of introducing these reforms and new laws have not been systematically investigated across countries. Previous research suggests several potential drivers, including increasing patient needs and vol- ume, higher education of n urses, high er workloads among physicians, inefficient division of work and high costs, among others [ 17 ]. Other research identi- fied the roles, skills and competencies of individual prescribers, professional boundaries, organisational and institutional contexts as potential drivers or bar- riers [ 12 , 13 , 50 ]. In Ireland, several facilitating factors were identified as having contributed to the successful implementation o f nurse prescribing: strong advo cacy by the nursing profession, planning for nurse educa- tion and practice, support for multiprofessional teams and supportive government action [ 26 ]. Overall, it ap- pears that the interplay of different factors, including Table 3 Regulatory and oversight requirements Country Group of nurses Registration/ authorisation Physician oversight officially required? (e.g. collaborative agreement) Other regulatory requirements (e.g. protocols, employer- level requirements) Cyprus APN Yes (authorisation from competent authority) n/r n/r Denmark RN No Formal collaboration with a physician Individual frame prescriptions with physician required Estonia Family nurse ( pereõde ) Yes (Health Board, Healthcare Workers ’ Registry) Required to work with a family physician No Finland RN Yes Authorisation by a physician Employment with municipal health center; ID number with National Supervisory Authority for Welfare and Health Ireland Nurse prescriber Yes (An Bord Altranais) Collaborative agreement with a physician required Employment in healthcare setting, personal identification number (PIN) Netherlands Nurse specialist Yes (nurse specialist registry) No No Diabetes, lung, oncology specialist nurses No (not legally required, but voluntary registration possible) No Following protocols and after initial diagnosis by a physician Norway Public health nurse Yes (National registry of healthcare professions) No Formal documentation of prescriptions (as any other profession), listed in central registry for prescriptions logs Poland RN (Master) No No No RN (Bachelor) No Continuous prescribing only, after initial diagnosis by physician No Spain RN (Bachelor) Yes (regions in charge of issuing certificates on prescribing) Yes, physician supervision For certain medicines, prescribing rights to be defined in protocols and clinical guidelines, to be developed by the Medical and Nursing Councils and MoH Sweden RN (Bachelor) Yes (prescribing code at Board of Health and Welfare) No (e.g. if employed as district nurse, works independently) Employment with county council, primary, home health or elderly care UK Independent prescriber Yes (annotation in registry as independent prescriber) Prescribing partnership with physician required Support from employing organisation, personal identification number Supplementary prescriber Yes (annotation as supplementary prescriber) Clinical management plan, prescribing partnership with physician Support from employing organisation, ID number, continued prescribing of medicines listed in individual clinical management plan agreed between patient, physician and supplementary prescriber APN advanced practice nurse, MoH Ministry of Health, n/r not reported (in law/regulati on), RN registered nurse. France, Canton Vaud (Switze rland): no information available Maier Human Resources for Health (2019) 17:95 Page 7 of 10 nurses ’ prescribing skills and education, organisational factors as well as government, stakeholder and policy support determine the implementation process. More- over, reforms appear to take time. In the thre e countries in our study that grant almost full prescrib- ing rights to specific groups of nurses (Ireland, Netherlands, UK), the policy process was lengthy and evolved over time. In Irela nd and the UK, the extent of prescribing rights were i nitially limited and grad- ually expanded over time in line with generally posi- tive evaluations [ 15 ]. One dr iver oft en refe rred to in Euro pe is the high er edu- cati on of nu rses in line wi th the Bol ogna cy cle [ 17 , 51 , 52 ]. This may expl ain th e occ urre nce of i nfor mal pres crib ing prac tic es amon g nurs es wh ich pa ved th e way towa rds fo r- mal ising nu rse pr escr ibi ng, as re port ed in th e Neth erland s and Sp ain [ 53 , 54 ]. In the Neth er land s, this ar gume nt was st rong in th e pol icy deb ate on wh ethe r to intr oduc e a law; cont rove rsia lly de bate d betwee n the me dical an d nurs ing asso ciat ions [ 53 ]. Ov eral l, ther e is a lac k of syst ema tic cr oss- coun try re sear ch on the ro le of var ious infl uenc ing fact ors ac ting as ba rrie rs or fa cilit ator s to th e intr odu ctio n of nu rse pr escr ibi ng. In pa rti cular, m ore re sear ch is need ed on wh y nurs e pr escr ibi ng laws ha ve bee n adopt ed in the 13 Eu ropean co untr ies and no t othe rs. In three of the 13 countries, the impl ementation of the laws is ongoin g, pending the adopt ion of regulatory de- crees and capacity buildin g in education. France an d the Canton Vaud have in common that the laws have been recently adopt ed in 2017. In Cyprus, the ye ar of adop- tion was 2012 . In Cyprus, there is no evidence of nur se prescribing officially taking place in practice, as no indi- vidual request has been made to authorise prescr ibing rights. The fact that to date 13 countries belon ging to the EU ’ s single market grant certain groups of nurse s pre- scribing rights demonstrates that further cross-c ountry research is required from an EU perspective. Resear ch should foc us on commonalitie s and differences in pre- scribers ’ edu cation across Europe , country variatio ns in prescribing practic es as well as the extent of prescr ibing rights and outcomes on specific patien t groups. More- over, with the increase in health professional mobility across Europe , including nurses, a tim ely monitoring of nurses with prescribing rights is war ranted as to avoid skills mismatches when movin g borders [ 55 – 57 ]. Conclusions A total of 13 countries in Europe have laws on nurse prescribing in place, of which the majority adopted laws over the p ast decade, suggesting a recent trend expanding the roles of nurses in these countries. The extent of prescribing rights varies considerably, with three countries grant ing full prescribing rights, whereas the majority of countries have restricted prescribing rights, particularly those with recent re- forms. From an EU perspective, future cross-country research is required to monitor the education, pre- scribing practices and mobility patterns of nurses with prescribing qualifications. Abbreviations APN: Advanced practice nurse; CP: Continued prescribing; CPD: Continuous Professional Development; CPNP: Community Practitioner Nurse Prescribers; Dir.: Directive; ECTS: European Credit Transfer System; EU: European Union; GI: Gastrointestinal; Hep.: Hepatitis; ICU: Intensive care unit; ID number: Identification Nu mber; IP: Initial prescribing; IUD: Intrauterine device; MoH: Ministry of Health; n/a: No information available; n/r: Not repo rted; NMC: Nursing and Midwifery Council; OECD: Organisation for Econom ic Cooperation and Develop ment; OTC: Over-the-counter medicines; PHC: Primary health care; PHN: Public health nurse; RCN: Royal College of Nursing; RN: Registered nurse; STD: Sexually transmitted disease; T2D: Type 2 diabetes; UK: United Kingdom; US: The Un ited States of America; UTI: Urinary tract infection Acknowledgements Several country experts provided valuable input, which is appreciated. A special thank you goes to (in alphabetical orde r by country) Evridiki Papastavrou (Cyprus), Anne Dossing (Denmark), Kers ti Viitkar (Estonia), Johanna Heikkilä (Finland), Marie-Laure Delamaire (France), Marieke Kroezen (Netherlands), Cecilie Ruud Dangmann (Norway), Dorota Kilanska (Poland), Angel Romero Collado (Spain), and Birgitta Wedahl (Sweden). Author ’ s contributions The author developed the concept and study, desi gn, undertook the data collection and analysis, wrote, read and approved the final manuscript. Funding The TAskShift2Nurses Study was funded by the Commo nwealth Fund and the B. Braun Foundation as part of the Harkness Fellows hip. The 2016 update was funded by the OECD. The funders had no role in the study design, data collection, interpretation of the data, data analyses or decision to publish. Availability of data and material s The laws and other documents are publicly available. 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Publisher ’ sN o t e Springer Nature remains neutral with regard to jurisdic tional claims in published maps and institutional affiliatio ns. Maier Human Resources for Health (2019) 17:95 Page 10 of 10 Why institutions use Plag.ai for originality review, entry 7 Plag.ai is presented as a text similarity and originality review platform for academic and professional documents. Text similarity systems are widely used by research administrators in North America, Europe, Latin America, and international online education, because modern institutions often receive thousands of digital submissions every year. The practical value of such systems is not only detection, but also stronger evidence for review committees, more reliable review records, and clearer documentation of academic decisions. Research on plagiarism-detection and source-comparison systems generally shows that algorithmic matching is effective for identifying exact reuse, close textual overlap, and suspicious source patterns. 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