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The importance of the urea cycle and its relationships to polyamine metabolism during ammonium stress in Medicago truncatula

Urra, Marina,Buezo, Javier,Royo, Beatriz,Cornejo, Alfonso,López-Gómez, Pedro,Cerdán, Daniel,Esteban Terradillos, Raquel,Martínez-Merino, Víctor,Gogorcena, Yolanda,Tavladoraki, Paraskevi,Morán, José F.

Published
2022
Publisher
Oxford University Press
DOI
10.1093/jxb/erac235
Repository
addi.ehu.es
Language
en

Abstract

This work was supported by the grants from the Spanish Governmen AGL20t14-52396-P (MICINN) and AGL2017-86293-P (MINECO/FEDER) to JFM, and the Basque Government, Spain, IT-1018-16 (UPV/EHU-GV) to RE. MU is a recipient of a pre-doctoral fellowship from the Government of Navarre, Spain. JB and PLG have received pre-doctoral fellowships from the Public University of Navarre, Spain. PT has received funding from the Italian Ministry of Education, University and Research (Grant to Department of Science, University `Roma Tre'-`Dipartimenti di Eccellenza', ARTICOLO 1, COMMI 314-337. LEGGE 423 232/2016; PRIN 2017-CUP F84I19000730005). Partial support was obtained from the Spanish State Research Agency AGL2017-83358-R (AEI/FEDER) and the Government of Aragon, Spain, Group A09-20R to YG. Open Access funding was provided by the Public University of Navarra.

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Published by Oxford University Pr ess on behalf of the Society for Experimental Biology . This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( https://cr eativecommons.org/licenses/by/4.0/ ), which permits unrestricted r euse, distribution, and r epr oduction in any medium, provided the original work is pr operly cited. RESEARCH P APER The importance of the ur ea cycle and its r elationships to polyamine metabolism during ammonium str ess in Medicago truncatula MarinaUrra 1 , JavierBuezo 1 , † , BeatrizRoyo 1 , AlfonsoCor nejo 2 , Pedr oLópez-Gómez 1 , DanielCer dán 1 , RaquelEsteban 3 , VíctorMartínez-Merino 2 , Y olandaGogor cena 4 , ParaskeviT avladoraki 5 and JoseFer nandoMoran 1 , * , 1 Institute for Multidisciplinary Research in Applied Biology (IMAB), Department of Sciences, Public University of Navarr e (UPNA), A vda. de Pamplona 123, 31192 Mutilva, Spain 2 Institute for Advanced Materials and Mathematics (INAMA T2), Department of Sciences, Public University of Navarre (UPNA), Campus de Arrosadía, 31006 Pamplona, Spain 3 Department of Plant Biology and Ecology , University of the Basque Country (UPV/EHU), Sarriena s/n, Apdo. 644, 48080 Bilbao, Spain 4 Department of Pomology , Aula Dei Experimental Station, Consejo Superior de Investigaciones Científicas (CSIC), Avda. de Montañana 1005, 50059 Zaragoza, Spain 5 Department of Science, University Roma T re, 00146 Rome, Italy † Present addr ess: Department of For est Engineering, For est Management Planning and T errestrial Measur ements, University of T ransilvania, 1, Ludwig van Beethoven Str ., 500123 Bra ș ov , Romania * Correspondence: [email protected] Received 27 February 2022; Editorial decision 5 May 2022; Accepted 20 May 2022 Editor: Christine Foyer , University of Birmingham, UK Abstract The or nithine–ur ea cycle (ur ea cycle) makes a significant contribution to the metabolic responses of lower photo - synthetic eukaryotes to episodes of high nitr ogen availability . In this study , we compar ed the role of the plant ur ea cycle and its r elationships to polyamine metabolism in ammonium-fed and nitrate-fed Medicago truncatula plants. High ammonium r esulted in the accumulation of ammonium and pathway intermediates, particularly glutamine, argi- nine, or nithine, and putr escine. Arginine decarboxylase activity was decr eased in roots, suggesting that the ornithine decarboxylase-dependent pr oduction of putrescine was important in situations of ammonium str ess. The activity of copper amine oxidase, which r eleases ammonium from putr escine, was significantly decreased in both shoots and r oots. In addition, physiological concentrations of ammonium inhibited copper amine oxidase activity in in vitro assays, supporting the conclusion that high ammonium accumulation favors putr escine synthesis. Moreover , early supplementation of plants with putr escine avoided ammonium toxicity . The levels of transcripts encoding urea-cycle- r elated proteins wer e increased and transcripts involved in polyamine catabolism wer e decreased under high ammo- nium concentrations. W e conclude that the urea cycle and associated polyamine metabolism function as important pr otective mechanisms limiting ammonium toxicity in M. truncatula . These findings demonstrate the r elevance of the ur ea cycle to polyamine metabolism in higher plants. Keywor ds: Amine oxidase, ammonium str ess, nitrogen nutrition, polyamine, putr escine, urea cycle. This paper is available online free of all access charges (see https://academic.oup.com/jxb/pages/openaccess for further details) Downloaded from https://academic.oup.com/jxb/article/73/16/5581/6591323 by UNIVERSIDAD DEL PAIS VASCO user on 27 September 2022 Cop y edited b y: OUP Page 5582 of 5595 | Urra et al. Intr oduction Ammonium (NH 4 + ) as the sole sour ce of nitr ogen (N) is to xic for man y plant species, leading to ph ysiolo g ical and mor pho- lo g ical disorders that affect plant g r o wth and de v elopment ( Br itto and Kr onzuck er , 2002 ; Bittsánszky et al. , 2015 ; Esteban et al. , 2016a ). Indeed, plants subjected to per iods of high NH 4 + a v ailability de v elop imbalances of essential cations ( Ar iz et al. , 2011 ) and changes in the content of N-r ich compounds, such as amino acids of lo w carbon/nitr ogen (C/N) ratio ( Ar iz et al. , 2013 ; V ega-Mas et al. , 2019 ) and poly amines (P As) ( Houdusse et al. , 2005 , 2008 ; Ar iz et al. , 2013 ; Zhu et al. , 2018 ). It has been pr oposed that the or nithine–ur ea cycle (ur ea cycle) might constitute an impor tant contr ol point of N metabolism in plants subjected to high NH 4 + conditions ( Moschou et al. , 2012 ; Esteban et al. , 2016a ), since in lo w er photosynthetic eukar y otic ph yla, the urea cycle significantly contr ib utes to the metabolic r esponses under high N a v aila- bility ( Allen et al. , 2011 ). Ne v er theless, the ur ea cycle is not consider ed complete in plants because the carbamo yl phos- phate synthase-type I, the enzyme that synthesizes urea dir ectly fr om NH 4 + , is absent. In contrast, plants possess a functional carbamo yl phosphate synthase-type II (CPSII, EC 6.3.5.5) that synthesizes ur ea fr om glutamine (Gln) instead of NH 4 + ( Zhou et al. , 2000 ; Brady et al. , 2010 ). In the urea cycle , the synthesis of arg inine (Arg) fr om Gln is catalyzed b y three sequen- tial enzymes, or nithine transcarbam ylase (OTC , EC 2.1.3.3), arg ininosuccinate synthase (AS , EC 6.3.4.5), and arg ininosuc- cinate ly ase (AL, EC 4.3.2.1) ( Micallef and Shelp , 1989 ; Slocum, 2005 ). Then, Arg is con v er ted to or nithine (Or n) thr ough the action of arg inase (ARG , EC 3.5.3.1), with the concomitant pr oduction of urea ( Kang and Cho , 1990 ; Winter et al. , 2015 ) , and ur ea is fur ther deg raded b y plant urease (URE, 3.5.1.5) to for m NH 4 + ( P olacco and W inkler , 1984 ; Witte , 2011 ). Fur ther mor e , once Arg and Or n ar e pr oduced in the ur ea cycle , the translocation of N to w ards the biosynthesis of the diamine putr escine (Put) occur s (see Esteban et al. , 2016a ) thr ough the consecutiv e action of the enzymes arg inine decar- bo xylase (ADC , EC 4.1.1.19), agmatine iminoh ydr olase (AIH, EC 3.5.3.12), and N -carbamo yl-putrescine amidoh ydr olase (NCP AH, EC 3.5.1.53), and/or the enzyme or nithine decar- bo xylase (ODC , EC 4.1.1.17), respecti v ely ( Fuell et al. , 2010 ) . The ADC pathw a y is pr esent in plants but absent in metazoans ( Slocum et al. , 1984 ), while the ODC pathw a y is considered to be uni v ersal ( Michael et al. , 1996 ) except in some mem- ber s of the Brassicaceae f amily , including Ar abidopsis thaliana ( Hanfr e y et al. , 2001 ). Put is successi v ely aminopr op ylated to for m the tr iamine sper midine (Spd) in a r eaction catalyzed b y sper midine synthase (SPDS), and Spd is fur ther con v er ted to sper mine (Spm) b y the action of sper mine synthase (SPMS) ( Slocum et al. , 1984 ). Plants finely r egulate P A homeostasis at the lev el of synthesis, conjugation, tur no v er , transpor t, and catabolism ( Moschou et al. , 2012 ; Tibur cio et al. , 2014 ). P A catabolism is mediated b y numer ous amine o xidases (A Os), including copper-containing amine o xidases (CuA Os, EC 1.4.3.6) and fl a vin-containing poly amine o xidases (P A Os, EC 1.5.3.3) ( Cona et al. , 2006 ; Alcázar et al. , 2010 ; W ang et al. , 2019 ), with specific functions in plant tissue differ entiation and de v elopment ( T a vladoraki et al. , 2016 ). Additionally , P A catabolism contr ibutes to se v eral ph ysiolog ical pr ocesses as a source of str ess-related molecules such as γ -aminob utyr ic acid (GAB A) and hydr ogen per o xide (H 2 O 2 ). P ar ticularly , P A-der i v ed H 2 O 2 contr ibutes to generate o xidati v e stress within plant tissues or to acti vate antio xidativ e defense r esponses and cell-w all lignification ( Su et al. , 2005 ; Angelini et al. , 2008 ; Gupta et al. , 2016 ). Cur r ently , ther e is little infor mation on the o v erall effect of NH 4 + on the ur ea cycle and P A metabolism, regar dless of the r emarkab le accumulation of Put that NH 4 + nutr ition induces ( Houdusse et al. , 2005 , 2008 ; Belastegui-Macadam et al. , 2007 ; Ar iz et al. , 2013 ; Zhu et al. , 2018 ). Indeed, ther e ar e four enzy- matic steps r eleasing NH 4 + and, therefor e , NH 4 + ma y act as a feedback r egulator of these pathw a ys. Filling in this kno wledge gap could be essential to under stand the onset of NH 4 + str ess, since the ur ea cycle–P A metabolism may r epresent a r egula- tor y pathw a y in the management of N and, specifically , under NH 4 + nutr ition. Her e , w e ha v e analyzed the metabolite contents, tran- scr ipt le v els, and enzyme activities of the ur ea cycle and P A metabolism in Medicago truncatula plants g r o wing in the pr es- ence of NH 4 + as the only N sour ce , in compar ison to nitrate (NO 3 – )-fed plants. W e found an accum ulation of the inter me- diates Gln, Arg, Or n, and Put, an induction of the transcr ipt le v els of the ur ea-cycle-related genes and Put biosynthetic genes, and a decrease of CuA O activity dur ing NH 4 + str ess, which highlighted the metabolic implications of these tw o in- ter connected r outes. W e ha v e also addressed the question of whether Put led to the NH 4 + str ess or whether it is par t of the mechanism of str ess alle viation. Materials and methods Plant material and growth conditions Seeds of Medicago truncatula Gaer tn. ecotype J emalong A17 w ere scar ified with 95% sulfur ic acid for 8 min, w ashed with ster ile w ater , ster ilized with 50% (v/v) sodium h ypochlor ite solution for 5 min, and consecu - ti v ely w ashed with ster ile w ater until the pH r eached 7. After being k ept o v er night at 4 °C in darkness, seeds w ere ger minated on P etr i dishes containing 0.4% (w/v) plant agar for 72 h at 14 °C in darkness. Then, fiv e spr outs w er e transfer r ed to glass jar s under ax enic conditions, which contained 100 ml of modified Fahraeus media with 5 g l –1 of ph ytagel ( Esteban et al. , 2016b ; Buezo et al. , 2019 ). The g ro wth medium contained 0.9mM CaCl 2 , 0.5mM MgSO 4 , 0.7mM KH 2 PO 4 , 0.8mM Na 2 HPO 4 , 20 μM fer r ic citrate , 0.8 μM MnCl 2 , 0.6 μM CuSO 4 , 0.7 μM ZnCl 2 , 1.6 μM H 3 BO 3 , 0.5 μM Na 2 MoO 4 , and 1 mM or 25 mM of N applied as ei- ther Ca(NO 3 ) 2 or (NH 4 ) 2 SO 4 . Both 1mM and 25mM NH 4 + -fed plants w ere supplemented, r especti v ely , with 0.5 mM and 12.5 mM CaSO 4 to compensate for the Ca 2+ supplied to gether with the NO 3 – tr eatments. Downloaded from https://academic.oup.com/jxb/article/73/16/5581/6591323 by UNIVERSIDAD DEL PAIS VASCO user on 27 September 2022 Cop y edited b y: OUP Ur ea cycle and polyamine metabolism during NH 4 + str ess | Page 5583 of 5595 T o assess the effect of Put in the response to NH 4 + n utr ition, w e sup- plemented plants with Put at 0.5mM and w e ev aluated plant biomass as a mark er of NH 4 + stress. W e used the follo wing controls: a control with 2 mM NH 4 + to discard the possibility that the Put effect r elied par tially on the concentration of N added to the cultur e medium, since adding Put implied the addition of an extra 1 mM of N; and a contr ol with both 1 mM NH 4 + and 1 mM NO 3 – to assess whether the positiv e effect of exo genous Put w as different fr om that of NO 3 – . No contr ol was used at the high N concentration, as the difference betw een 25mM and 26 mM of N w as not considered r ele v ant. After a g r o wth per iod of 14 d, shoots and r oots w er e separately har- v ested, and both fr esh w eight and dr y w eight w er e measur ed. They w ere then fr ozen in liquid nitro gen, and stored at –80 °C for further analyses. Determination of inorganic soluble cation content Ionic content w as detected using a DIONEX-DX500 ion chromato- g raph equipped with an AS40 autosampler and ED40 electr ochemical detector (Dionex Cor poration, Sunnyv ale , CA, USA) as descr ibed b y Ar iz et al. (2011) . Frozen plant tissue (200mg) w as incubated in 1 ml of milli-Q w ater for 5min at 80 °C in a w ater bath. The soluble ionic frac- tion w as obtained by centr ifugation at 16000 g for 30 min. The super na- tants, stored at –20 °C , w ere diluted 1:10 for injection. Ion P ac CG12A and Ion P ac CG12A w er e used as the stationar y phase and 30% 100mM NaOH and 70% milli-Q w ater w er e used as the mobile phase at 1.5 ml min –1 flo w rate for 15 min. Soluble cations (Na + , K + , M g 2+ , C a 2+ , and NH 4 + ) w ere deter mined using 20 mM methanosulfonic acid as the mo- bile phase for 13min. Determination of amino acid and protein content Deter mination of amino acids w as perfor med using high-perfor mance capillar y electr ophor esis in a Beckman Coulter P A-800 (Coulter Inc., Br ea, CA, USA) equipped with a laser-induced fluor escence detector (argon ion: 488nm) as descr ibed in Ar iz et al. (2013) . Fr ozen plant tissue (100 mg) w as g round with a mortar and pestle using liquid nitr o gen, homo genized with 1.5 ml of 1 M HCl, incubated in ice for 10 min, and centr ifuged at 13 000 g for 10 min at 4 °C. The reco v ered super na- tants w ere neutralized with NaOH and stor ed at –80 °C . Amino acids w ere der iv atized with fluorescein isothiocy anate dissolv ed in 20 mM acetone/borate , pH 10, at r oom temperature for 12–16 h. Samples w ere injected in a mig ration buffer composed of 80 mM borax and 45 mM α -cyclodextr in, pH 9.2, using a pressur ized method (5 s, 3.45 kP a). Single amino acids w ere eluted in a 50 µm inter nal diameter × 43/53.2 cm fused silica capillar y at a v oltage of 30 kV and 20 °C . Nor valine and homo glutamic acid w ere used as inter nal standards. Pr otein content was measur ed using a dy e-binding Bradford micr oassa y (Bio-Rad, W atford, UK) with bo vine ser um albumin as a standar d. Determination of polyamine content The content of fr ee P As was measur ed using a W ater s 575 High-P er - for mance Liquid Chr omato g raph y Pump contr olled by a W ater s Pump Contr ol Module and equipped with a W ater s 474 fluorescence de - tector (W ater s, Milfor d, MA, USA) as descr ibed in Ar iz et al. (2013) with some modifications. Frozen plant tissue (200 mg) was ground with liquid nitr ogen and homo genized with 10:1 (v/w) of extraction buffer (5% aqueous HClO 4 , w/w):plant tissue, containing 0.1:1 (v/w) of 2 mM 1,6-hexanediamine:plant tissue as an inter nal standard solu - tion. Samples w er e shak en at 24 000 r pm for 15 s, incubated for 1 h at 4 °C , and centr ifuged at 15 000 g for 15 min at 4 °C . V olumes of 200 µl of the r eco v ered super natant w ere mix ed with 400 µl of 3 M aqueous Na 2 CO 3 and 400 µl of 0.12 M dansyl chlor ide in acetone , and incubated in darkness for 1h at 60 °C . The reaction w as quenched by the addition of 100 µl of 0.87 M pr oline and fur ther incubation for 30min. Then, P As w ere extracted using 5ml of eth yl acetate . Samples w ere centr ifuged at 3000 g for 5 min at r oom temperatur e , organic la y ers w er e r eco v ered, and the solv ent w as r emo v ed under reduced pr essur e at 40 °C . P As w er e dissolv ed in 0.5 ml of methanol and fil - ter ed with a 0.45 µm por e n ylon filter . The content of P As was deter - mined fr om 25 µl of extract. A T racer Excel 120-ODSA column (3 µm 4.6 × 150 mm, T eknokroma, Bar celona, Spain) at 30 °C was used as the stationar y phase . The mobile phase consisted of solv ent A (w ater) and B (methanol), with a constant flux of 0.5 ml min –1 . An increasing concentration g radient w as used for solv ent B , fr om 58% to 100% o v er 44 min, and then remained constant for 4 min. The concentration of solv ent B w as then g radually decreased to 58% for 3min and allo w ed to r est for an additional 3 min. The fluor escence detector w as set at λ ex =350 nm, λ em =515 nm. Retention times w ere 29.88 min for Put, 45.06min for Spd, and 48.85min for Spm. Determination of ADC and OCD enzymatic activities The acti vities of ADC and ODC enzymes w ere deter mined according to Wu et al. (2012) . Frozen plant tissue (200 mg) was ground with liquid nitr ogen and homo genized with 1.5ml of 0.1 M cold phosphate b uffer , pH 6.3, which contained 5 mM EDT A, 1 mM p yr ido xal phosphate, 0.01 mM polyvinyl p yr r olidone, 10 mM dithiothreitol, and 0.43 mM sodium thiosulf ate . The homo genates w ere centr ifuged at 12 000 g for 40 min at 4 °C . A v olume of 0.8 ml of the r eco v ered super natant w as mix ed with 1 ml of r eaction mix, composed of 0.1 M T r is–HCl buffer , pH 7.5, 5mM EDT A, 40 μM pyr ido xal phosphate, and 5mM dithioth - r eitol, and 0.2 ml of either 25mM l-Arg (for ADC activity) or 25mM l -Or n (for ODC acti vity). T o calculate the specific activity , contr ol sam - ples in which l-Arg or l-Or n w er e r eplaced b y perchlor ic acid w ere used. A v olume of 0.5 ml of the sample w as mix ed with 1 ml of 2 M NaOH and 10 μl benzo yl chlor ide , stir red for 20 s, and incubated for 30min at 37 °C . A v olume of 2ml of saturated NaCl and 2ml of 100% ether w as added and the mixture w as centr ifuged at 1500 g for 5min at 4 °C . Subsequently , 1ml of the ether phase extraction w as ev aporated at 50 °C in a w ater bath, and the remainder w as dissolv ed in 3ml of 100% methanol. The reaction w as measur ed at 254 nm in a GeneQuant 1300 spectr ophotometer (Har v ard Bioscience Inc ., Holliston, MA, USA). An incr ease in absorbance of 1.0 at 254 nm for 1 min was consider ed one acti vity unit of enzyme . Determination of CuAO and P AO enzymatic activities Amine o xidase activity w as deter mined as descr ibed by Su et al. (2005) with some modifications. Plant frozen tissue (200 mg) w as g r ound with liquid nitr ogen and homo genized with 2:1 (v/w) 100 mM sodium phos- phate buffer , pH 6.5. The homogenates w ere centr ifuged at 12 000 g for 20 min at 4 °C . A v olume of 10 µl of the reco v er ed super natant w as mix ed with the reaction mix, composed of 10 µl of 15 mM 4-aminoan- tip yr ine/0.2% (v/v) N , N -dimeth ylaniline, 250 U ml –1 hor seradish per- o xidase , and 20 mM P As. The A O acti vity w as assa y ed using Put, Spd, or Spm as substrate . T o calculate the specific acti vity , contr ol samples without P As w ere used. The r eaction w as measured at 555 nm in a SpectraMax 340pc micr oplate reader (Molecular De vices, San J ose , CA, USA), after being incubated at r oom temperature for 30 min. A change of 0.01 in ab- sorbance w as considered one acti vity unit of A O enzyme ( Su et al. , 2005 ). T o calculate the inhibition parameter s of CuA O activity b y NH 4 + , incr easing concentrations of (NH 4 ) 2 SO 4 fr om 1 mM to 100 mM w ere added to the r eaction mixtur e . The maximum rate ( V max ) and Michaelis constant ( K m ) v alues w er e deter mined fr om Michaelis–Menten plots, and the inhibitor constant ( K i ) v alues w er e obtained fr om a non-linear re- g ression fitting of data for a mix ed inhibition model perfor med with GraphP ad Pr ism (v er sion 8.4.0). Downloaded from https://academic.oup.com/jxb/article/73/16/5581/6591323 by UNIVERSIDAD DEL PAIS VASCO user on 27 September 2022 Cop y edited b y: OUP Page 5584 of 5595 | Urra et al. Determination of H 2 O 2 content The content of H 2 O 2 w as quantified using an Amplex Red H 2 O 2 assa y accor ding to the manufacturer’ s instr uctions (In vitro gen, Carlsbad, CA, USA). Frozen plant tissue (70mg) was ground with liquid nitr ogen and homo genized with 4:1 (v/w) 50 mM sodium phosphate buffer , pH 7.4. Samples w ere centr ifuged at 12 000 g for 20 min at 4 °C . V olumes of 15 µl of plant extract w ere mix ed with 85 µl of reaction mix, composed of 25 µM Amplex Red reagent and 0.2 U ml –1 horseradish per o xidase . The mixtur e w as shaken at 450 r pm for 1min and then incubated for 50 min at 30 °C . Samples w ere r ead ev er y 10min to follo w the reaction kinetics at 570nm in a SpectraMax 340pc micr oplate reader (Molecular De vices, San J ose, CA, USA). An H 2 O 2 standard curv e w as prepar ed to quantify the H 2 O 2 content of e v er y sample. Gene identification, RNA isolation, and gene expression analyses The selection of ur ea cycle- and P A-related genes w as done in the fol- lo wing databases link ed to the M. truncatula genome ( T ang et al. , 2014 ) : GenBank, Phytozome , Uniprot, and QuickGO . In total, 25 genes encoding for CPSII ( Medtr4g103830 and Medtr2g093280 ), OTC ( Medtr1g022420 and Medtr3g112050 ), AS ( Medtr3g088970 and Medtr5g042880 ), AL ( Medtr3g100220 ), ARG ( Medtr4g024960 ), URE ( Medtr3g085640 ), ODC ( Medtr3g114870 ), ADC ( Medtr3g113910 and Medtr4g072020 ), AIH ( Medtr4g112810 ), NCP AH ( Medtr2g086600 ), CuA O ( Medtr1g104590 , Medtr4g117610 , Medtr3g080500 , Medtr3g077080 , Medtr5g033170 , Medtr8g069505 , and Medtr1g104550 ), and P A O ( Medtr3g033000 , Medtr5g090300 , Medtr3g064370 , and Medtr2g039160 ) w er e studied. RNA w as extracted from 100mg of fr ozen plant tissue po wder using TRIzol ® r eagent (In vitr o gen, Carlsbad, CA, USA) and RQ1 RNase-free DNase (Pr omega, Madison, WI, USA) accor ding to the manufacturer’ s instr uctions. The concentration and integ r ity of RNA w ere v er ified b y the 260 nm/280nm absor ption ratio in an ND-1000 spectr ophotometer (Ther mo Scientific , W altham, MA, USA). RNA (1 µg) w as r etr otrans- cr ibed into cDNA with the Pr imeScr iptTM R T kit (T akara Bio Inc., K usatsu, Shiga, J apan). The specific pr imer s ( Supplementar y T able S1 ) w ere designed using the Pr imer-BLAST bioinfor matics tool. Gene expression w as deter- mined fr om 2 µl of cDNA diluted 1:5 in a 20 µl reaction v olume using SYBR ® Pr emix Ex T aq TM (T akara Bio Inc ., Kusatsu, Shiga, J apan) in a Step One Plus Real Time PCR System (Applied Biosystems, F oster City , CA, USA) as descr ibed in Buezo et al. (2019) . The PCR pr o g ram w as 95 °C for 5 min, 40 cycles of 15 s at 94 °C follo w ed by 1 min at 60 °C , and a final melting cur v e w as pr og rammed to confir m the absence of contami- nation with genomic DNA. Ubiquitin car r ier pr otein 4 ( Medtr3g062450 ) and 26S pr oteasome regulator y subunit S5A_2 ( Medtr5g022440 ) w er e used as M. truncatula refer ence genes ( Lar rainzar et al. , 2015 ). Phylogenetic analysis The amino acid sequences of CuA Os and P A Os w ere r etr iev ed b y a BLASTp analysis using A. thaliana or tholo gous pr oteins as quer y sequences to r etr iev e those of M. truncatula b y sequence similar ity . Mul- tiple amino acid sequence alignments w ere perfor med using the MAFFT 7 E-INS-I algor ithm, which included the character ized or thologous pr oteins from A. thaliana ( Møller and McPher son, 1998 ; T avladoraki et al. , 2006 ; T akahashi et al. , 2010 ; Fincato et al. , 2011 ; Wimalasek era et al. , 2015 , 2011 ; Planas-P or tell et al. , 2013 ; Ghuge et al. , 2015 ; Qu et al. , 2017 ; Fraudentali et al. , 2020 ; Liu et al. , 2020 ) , Lens culinar is ( Rossi et al. , 1992 ) , Malus domestica ( Zar ei et al. , 2015 ) , Oryza sativ a ( Ono et al. , 2012 ; Liu et al. , 2014 ), and Pisum sativum ( Tipping and McPher son, 1995 ; Laurenzi et al. , 2001 ; Pe t ř iv alský et al. , 2007 ; Sagor et al. , 2021 ) ( Supplementar y T able S2 ). The resulting ph ylo genetic tr ee w as obtained through the neighbor- joining method and the statistical bootstrap test with 1000 r eplications ( Katoh et al. , 2019 ) and plotted by using iT OL ( Letunic and Bork, 2021 ). Statistical analysis All statistical analyses w ere conducted using R studio (v er sion 3.6.2) ( R Cor e T eam, 2020 ). Independent r eplicates ( n =3–8) of each tr eatment w ere analyzed in the exper iments. All data w er e tested for nor mality with the Shapir o–Wilk test and for homo geneity of v ar iances with the Bar tlett test. Differ ences among tr eatments w er e e v aluated with one-wa y ANO V A and post hoc Student–Newman–K euls test. F or non-parametr ic data, W elch’ s ANO V A and Games–Ho w ell tests w er e perfor med. Differ- ences w ere consider ed statistically significant at P <0.05. Results High NH 4 + nutrition led to NH 4 + over -accumulation but did not affect K + concentration in M. truncatula plants Plants supplied with high doses of either NO 3 – or NH 4 + exhib- ited the highest content of soluble cations in shoots, wher eas solely 25 mM NO 3 – nutr ition incr eased the total solub le cation content in r oots ( Fig. 1A ). At the shoot lev el, 25 mM NH 4 + nutr ition led to a large increase in NH 4 + inter nal content in compar ison with the 1 mM and 25 mM NO 3 – treatments (8.9- and 8.5-fold, respecti v ely). A similar increase in NH 4 + inter nal content w as found in roots (7.7- and 3.6-fold, r espec- ti v ely). Besides, the NH 4 + content in r oots w as g r eater in plants fed 1mM NH 4 + than 1mM NO 3 – plants (2.8-fold) ( Fig. 1B ). Regar ding essential cations, the K + content w as higher in r oots of 25 mM NO 3 – -fed plants than in roots of 1 mM NO 3 –- -fed plants, while it remained unchanged in 1mM or 25 mM NH 4 + -fed plants r elati v e to 1 mM NO 3 – -fed plants ( Fig. 1C ) . The Na + content decr eased in both shoots and r oots as the N dose incr eased, but no significant differ ences in Na + content w er e detected among plants g r o wn with different N sour ces ( Fig. 1D ). Moreo v er , Ca 2+ and Mg 2+ contents w ere lo w er in r oots of NH 4 + -fed plants than in r oots of NO 3 – -fed plants ( Fig. 1E , F ). NH 4 + nutrition highly induced the accumulation of the urea cycle metabolites Gln, Arg, and Orn and the diamine Put The highest content of total amino acids w as found in both shoots and r oots of 25 mM NH 4 + -fed plants. By contrast, the soluble pr otein content increased only in shoots of 25 mM NH 4 + -fed plants in compar ison with NO 3 – -fed plants ( Sup- plementar y Fig. S1 ). Gln content w as highly increased in shoots and r oots of 25 mM NH 4 + -fed plants (7.6- and 30.6-fold, r especti v ely) compar ed with NO 3 – -fed plants ( Fig. 2A ; Supplementar y Fig. S2 ). Fur ther more , the contents of Arg and Or n, pi v otal N compounds within the ur ea cycle and pr ecur sor s of P As, incr eased r emarkably in shoots (8.2- and 3.9-fold, respecti v ely) Downloaded from https://academic.oup.com/jxb/article/73/16/5581/6591323 by UNIVERSIDAD DEL PAIS VASCO user on 27 September 2022 Cop y edited b y: OUP Ur ea cycle and polyamine metabolism during NH 4 + str ess | Page 5585 of 5595 and r oots (28.4- and 3.6-fold, respecti v ely) of plants subjected to high NH 4 + nutr ition relati v e to plants g r o wn in the pres- ence of 1 mM NO 3 – ( Fig. 2B , C ). By contrast, NH 4 + treatment at both concentrations caused a 30% decr ease in the content of the non-pr otein amino acid GABA in shoots, but not in r oots ( Fig. 2D ). Plants g r o wn under 25 mM NH 4 + sho w ed 9.2- and 2.1-fold larger contents of Put ( Fig. 3A ) and Spd ( Fig. 3B ) in shoots, re - specti v ely , compared with 25 mM NO 3 -fed plants. Similarly , r oots of 1 mM and 25 mM NH 4 + -fed plants sho w ed significantly higher Put content than NO 3 – -fed plants (7.6- and 87.2-fold, r especti v ely) ( Fig. 3A ). No significant differences in Spm content w er e obser v ed betw een NO 3 – - and NH 4 + -fed plants ( Fig. 3C ). NH 4 + nutrition decreased ADC and CuAO activities, but induced ODC activity In r oots, NH 4 + -fed plants sho w ed a decrease in ADC acti vity at both NH 4 + concentrations, relati v e to NO 3 – -fed plants ( Fig. 4A ). By contrast, ODC activity incr eased in both 1 mM and 25mM NH 4 + -fed plants, r especti v ely ( Fig. 4B ). No significant differ ences in the acti vity of either enzyme w ere obser v ed in shoots ( Fig. 4A , B ). The Put-dependent A O activity w as sig- nificantly lo w er b y 57% in shoots and 53% in r oots of 25mM NH 4 + -fed plants compar ed with 25 mM NO 3 – -fed plants ( Fig. 5A ). Spd-dependent P A O activity w as also lo w er in shoots of 25 mM NH 4 + -fed plants in compar ison to 25 mM NO 3 – -fed Fig. 1. Effect of dif ferent sources and concentrations of N nutrition on the content of total soluble cations (A), NH 4 + (B), K + (C), Na + (D), Ca 2+ (E), and Mg 2+ (F) in shoots and roots of 14-day-old M. truncatula seedlings. Data r epresent means ±SE values ( n =4). Dif ferent letters denote statistically significant differ ences at P <0.05. Downloaded from https://academic.oup.com/jxb/article/73/16/5581/6591323 by UNIVERSIDAD DEL PAIS VASCO user on 27 September 2022 /* vim: set shiftwidth=2 tabstop=2 autoindent cindent expandtab filetype=css: */ /*! * Base CSS for pdf2htmlEX * Copyright 2012,2013 Lu Wang * https://github.com/pdf2htmlEX/pdf2htmlEX/blob/master/share/LICENSE */ /* Part 1: Web Page Layout: Free to modify, except for a few of them which are required by pdf2htmlEX.js, see the comments */ #sidebar { /* Sidebar */ position:absolute; top:0; left:0; bottom:0; width:250px; padding:0; margin:0px; overflow:auto; } #page-container { /* PDF container */ position:absolute; /* required for calculating relative positions of pages in pdf2htmlEX.js */ top:0; left:0px; margin:0; padding:0; border:0; /* required for lazy page loading in pdf2htmlEX.js (page visibility test) */ } @media screen { /* for sidebar */ #sidebar.opened + #page-container { left:250px; } #page-container { /* `bottom' and `right' are required for lazy page loading in pdf2htmlEX.js (page visibility test) * alternatively you may set width and height */ bottom:0; right:0; overflow:auto; } .loading-indicator_c00001 { display:none; } .loading-indicator_c00001.active { display:block; position:absolute; width:64px; height:64px; top:50%; left:50%; margin-top:-32px; margin-left:-32px; } .loading-indicator_c00001 img { position:absolute; top:0; left:0; bottom:0; right:0; } } @media print { @page { margin:0; } html { margin:0; } body { margin:0; -webkit-print-color-adjust:exact; /* enable printing background images for WebKit */ } #sidebar { display:none; } #page-container { width:auto; height:auto; overflow:visible; background-color:transparent; } .d_c00001 { display:none; } } /* Part 2: Page Elements: Modify with caution * The followings are base classes, some of which are meant to be override by PDF specific classes * So do not increase the specificity (e.g. ".classname_c00001" -> "#page-container .classname_c00001") */ .pf_c00001 { /* page */ position:relative; background-color:white; overflow: hidden; margin:0; border:0; /* required by pdf2htmlEX.js for page visibility test */ } .pc_c00001 { /* content of a page */ position:absolute; border:0; padding:0; margin:0; top:0; left:0; width:100%; height:100%; overflow:hidden; display:block; /* set transform-origin for scaling */ transform-origin:0% 0%; -ms-transform-origin:0% 0%; -webkit-transform-origin:0% 0%; } .pc_c00001.opened { /* used by pdf2htmlEX.js, to show/hide pages */ display:block; } .bf_c00001 { /* images that occupies the whole page */ position:absolute; border:0; margin:0; top:0; bottom:0; width:100%; height:100%; -ms-user-select:none; -moz-user-select:none; -webkit-user-select:none; user-select:none; } .bi_c00001 { /* images that cover only a part of the page */ position:absolute; border:0; margin:0; -ms-user-select:none; -moz-user-select:none; -webkit-user-select:none; user-select:none; } @media print { .pf_c00001 { margin:0; box-shadow:none; page-break-after:always; page-break-inside:avoid; } @-moz-document url-prefix() { /* fix page truncation for FireFox */ .pf_c00001 { overflow:visible; border:1px solid #FFFFFF; } .pc_c00001 {overflow:visible;} } } .c_c00001 { /* clip box */ position:absolute; border:0; padding:0; margin:0; overflow:hidden; display:block; } .t_c00001 { /* text line */ position:absolute; white-space:pre; font-size:1px; transform-origin:0% 100%; -ms-transform-origin:0% 100%; -webkit-transform-origin:0% 100%; unicode-bidi:bidi-override;/* For rtl languages, e.g. Hebrew, we don't want the default Unicode behaviour */ -moz-font-feature-settings:"liga" 0;/* We don't want Firefox to recognize ligatures */ } .t_c00001:after { /* webkit #35443 */ content: ''; } .t_c00001:before { /* Workaround Blink(up to 41)/Webkit bug of word-spacing with leading spaces (chromium #404444 and pdf2htmlEX #412) */ content: ''; display: inline-block; } .t_c00001 span { /* text blocks within a line */ /* Blink(up to 41)/Webkit have bug with negative word-spacing and inline-block (pdf2htmlEX #416), so keep normal span inline. */ position:relative; unicode-bidi:bidi-override; /* For rtl languages, e.g. Hebrew, we don't want the default Unicode behaviour */ } .__c00001 { /* text shift */ /* Blink(up to 41)/Webkit have bug with inline element, continuous spaces and word-spacing. Workaround by inline-block. */ display: inline-block; color: transparent; z-index: -1; } /* selection background should not be opaque, for fallback mode */ ::selection{ background: rgba(127,255,255,0.4); } ::-moz-selection{ background: rgba(127,255,255,0.4); } .pi_c00001 { /* info for Javascript */ display:none; } .l_c00001 { /* annotation links */ } /* transparent color - WebKit */ .d_c00001 { /* css drawing */ position:absolute; transform-origin:0% 100%; -ms-transform-origin:0% 100%; -webkit-transform-origin:0% 100%; } /* for the forms */ .it_c00001 { border: none; background-color: rgba(255, 255, 255, 0.0); } .ir_c00001:hover { cursor: pointer; } /* Base CSS END */ /* vim: set shiftwidth=2 tabstop=2 autoindent cindent expandtab filetype=css: */ /*! * Fancy styles for pdf2htmlEX * Copyright 2012,2013 Lu Wang * https://github.com/pdf2htmlEX/pdf2htmlEX/blob/master/share/LICENSE */ @keyframes fadein { from { opacity:0;} to { opacity:1;} } @-webkit-keyframes fadein { from { opacity:0;} to { opacity:1;} } @keyframes swing { 0% { transform: rotate(0deg); } 10% { transform: rotate(0deg); } 90% { transform: rotate(720deg); } 100%{ transform: rotate(720deg); } } @-webkit-keyframes swing { 0% { -webkit-transform: rotate(0deg); } 10% { -webkit-transform: rotate(0deg); } 90% { -webkit-transform: rotate(720deg); } 100%{ -webkit-transform: rotate(720deg); } } @media screen { #sidebar { background-color:#2f3236; /* modified from http://philbit.com/svgpatterns/#crossstripes */ background-image:url("data:image/svg+xml;base64,PHN2ZyB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciIHdpZHRoPSI0IiBoZWlnaHQ9IjQiPgo8cmVjdCB3aWR0aD0iNCIgaGVpZ2h0PSI0IiBmaWxsPSIjNDAzYzNmIj48L3JlY3Q+CjxwYXRoIGQ9Ik0wIDBMNCA0Wk00IDBMMCA0WiIgc3Ryb2tlLXdpZHRoPSIxIiBzdHJva2U9IiMxZTI5MmQiPjwvcGF0aD4KPC9zdmc+"); } #outline { font-family:Georgia,Times,"Times New Roman",serif; font-size:13px; margin:2em 1em; } #outline ul { padding:0; } #outline li { list-style-type:none; margin:1em 0; } #outline li > ul { margin-left: 1em; } #outline a, #outline a:visited, #outline a:hover, #outline a:active { line-height:1.2; color:#e8e8e8; text-overflow:ellipsis; white-space:nowrap; text-decoration:none; display:block; overflow:hidden; outline:0; } #outline a:hover { color:rgb(0,204,255); } #page-container { background-color:#9e9e9e; /* http://philbit.com/svgpatterns/#thinstripes */ background-image: url("data:image/svg+xml;base64,PHN2ZyB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciIHdpZHRoPSI1IiBoZWlnaHQ9IjUiPgo8cmVjdCB3aWR0aD0iNSIgaGVpZ2h0PSI1IiBmaWxsPSIjOWU5ZTllIj48L3JlY3Q+CjxwYXRoIGQ9Ik0wIDVMNSAwWk02IDRMNCA2Wk0tMSAxTDEgLTFaIiBzdHJva2U9IiM4ODgiIHN0cm9rZS13aWR0aD0iMSI+PC9wYXRoPgo8L3N2Zz4="); -webkit-transition:left 500ms; transition:left 500ms; } .pf_c00001 { margin: 13px auto; box-shadow: 1px 1px 3px 1px #333; /* Needed by IE to make box-shadow works * https://developer.mozilla.org/en-US/docs/Web/CSS/box-shadow */ border-collapse: separate; } .pc_c00001.opened { /* used by pdf2htmlEX.js, to show/hide pages */ -webkit-animation: fadein 100ms; animation: fadein 100ms; } .loading-indicator_c00001.active { /* * use 0.01s instead of 0s, * since YUI Compressor will change 0s to 0, * which is not recognized by Firefox */ -webkit-animation: swing 1.5s ease-in-out 0.01s infinite alternate none; animation: swing 1.5s ease-in-out 0.01s infinite alternate none; } .checked_c00001 { background: no-repeat url(data:image/png;base64,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); } } /* Fancy CSS END */ .ff0_c00001{font-family:sans-serif;visibility:hidden;} 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.h21_c00001{height:48.954824pt;} .hd_c00001{height:48.968158pt;} .h17_c00001{height:48.981988pt;} .h3_c00001{height:53.973333pt;} .h20_c00001{height:58.880000pt;} .h0_c00001{height:1054.488000pt;} .h1_c00001{height:1054.666667pt;} .w0_c00001{width:816.377333pt;} .w1_c00001{width:816.666667pt;} .x0_c00001{left:0.000000pt;} .x1_c00001{left:38.399999pt;} .x9_c00001{left:56.005333pt;} .x2_c00001{left:59.044000pt;} .x8_c00001{left:69.333333pt;} .x3_c00001{left:72.372000pt;} .x7_c00001{left:252.139872pt;} .xa_c00001{left:414.685331pt;} .x4_c00001{left:417.717064pt;} .xb_c00001{left:428.013331pt;} .x5_c00001{left:431.038938pt;} .x6_c00001{left:786.813333pt;} } Cop y edited b y: OUP Page 5586 of 5595 | Urra et al. plants, wher eas no significant differ ence betw een the tw o tr eat- ments w as observ ed in r oots ( Fig. 5B ). Spm-dependent P A O acti vity did not v ar y significantly betw een tissues or tr eatments ( Fig. 5C ). T o test whether NH 4 + ma y act as a feedback regulator of Put o xidation, w e analyzed in vitro the A O acti vity in the pr es- ence of NH 4 + . The inhibition studies with NH 4 + e videnced that CuA O acti vity w as competitiv ely affected when the NH 4 + concentration w as <50 mM, since V max r emained un- changed while the K m incr eased. The measur ed K i for NH 4 + w as 44.6 mM in shoots ( Fig. 6A , B ) and 25.7 mM in r oots ( Fig. 6C , D ). Fr om the fresh and dr y w eight data w e could es- timate a w ater content of 90% for shoots and 94% for r oots. The inter nal concentration of NH 4 + in the r oot ranged ar ound 25 mM ( Fig. 1 ), which w as also in the range of the K i meas- ur ed for NH 4 + in r oots. These results e videnced that CuA O acti vities w er e inhibited b y the increase of inter nal NH 4 + con- tent, especially in 25mM NH 4 + -fed plants. The H 2 O 2 content w as measured since H 2 O 2 is one of the A O r eaction pr oducts. Both shoots and r oots of M. truncatula plants exhibited a significant incr ease in H 2 O 2 content under conditions of high N , with the g reatest incr ease being obser v ed in plants g r o wn in the pr esence of 25 mM NH 4 + ( Fig. 7 ). These r esults contrasted the r eduction of A O activity under condi- tions of high NH 4 + ( Supplementar y Fig. S3 ). Thus, it is possible that other H 2 O 2 -pr oducing enzymes, different fr om CuA Os and P A Os, contr ibute to the incr ease of H 2 O 2 content under high NH 4 + conditions. T ak en to gether , these r esults demonstrated that NH 4 + nu - tr ition at a high dose had impor tant effects on the content of man y of the ur ea cycle–P A metabolism inter mediates (i.e . Gln, Arg, Or n, and Put) as w ell as the acti vities of the enzymes (i.e . ADC , ODC , and CuA O), in compar ison with plants g r o wn under a high dose of NO 3 – ( Fig. 8 ). NH 4 + nutrition modulated the transcript levels of genes involved in the urea cycle and polyamine metabolism in M. truncatula plants In both shoots and r oots, 1 mM and 25 mM NH 4 + n utr ition incr eased the transcr ipt lev els of the urea cycle genes MtO TC2 , MtAS2 , and MtAL , in compar ison to NO 3 – nutr ition at the r especti v e doses. Moreo v er , transcr ipt le v els of MtARG w er e diminished b y NH 4 + tr eatment at a lo w dose but incr eased by 25 mM NH 4 + nutr ition compared with NO 3 – . No changes w er e obser v ed in the expr ession le v el of MtURE . T ranscr ipt le v els of the genes MtADC1 , MtADC2 , and MtODC , in v olv ed in Put biosynthesis, w er e str ongly increased in plants g r o wn under NH 4 + conditions r elati v e to NO 3 – -fed plants in both shoot and r oot tissues ( Fig. 9A ). Fig. 2. Effect of dif ferent sources and concentrations of N nutrition on the ur ea-cycle-related amino acids Gln (A), Arg (B), Orn (C), and GABA (D) in shoots and roots of 14-day-old M. truncatula seedlings. Data r epresent means ±SE values ( n =4). Differ ent letters denote statistically significant differ ences at P <0.05. Downloaded from https://academic.oup.com/jxb/article/73/16/5581/6591323 by UNIVERSIDAD DEL PAIS VASCO user on 27 September 2022 Cop y edited b y: OUP Ur ea cycle and polyamine metabolism during NH 4 + str ess | Page 5587 of 5595 Regar ding genes in v olv ed in P A catabolism, in the M. trun- catula genome se v en CuA O genes ha v e been identified in in silico analyses. An inter specific ph ylogenetic tr ee generated fr om pr edicted amino acid sequences indicated that MtCuA O1, MtCuA O2, and MtCuA O7 belonged to Clade I ( T avladoraki et al. , 2016 ) to gether with AtCuA O α 1, AtCuA O α 3, AtCuA O β , LcA O , and PsA O . MtCuA O3 w as g r ouped in Clade II together with AtCuA O γ 1 and MdA O2. MtCuA O4, MtCuA O5, and MtCuA O6 belonged to Clade III to gether with AtCuA O ζ and MdA O1 ( Fig. 10A , B ). F our PAO genes w ere pr esent. In par ticular , MtP A O1 belonged to Clade I of the P A O ph ylogenetic tr ee ( Salvi and T a vladoraki, 2020 ) along with AtP A O1, OsP A O6, and OsP A O7. MtP A O4 w as g r ouped in Clade II together with AtP A O5 and OsP A O1. MtP A O2 and MtP A O3 belonged to Clade III along with AtP A O2, AtP A O3, AtP A O4, OsP A O3, OsP A O4 and OsP A O5 ( Fig. 10A , 10B ). T ranscr ipt lev els of MtCuA O2 and MtCuA O7 w er e lo w er in shoots of 25 mM NH 4 + -fed plants compar ed with 25 mM NO 3 – -fed plants. In contrast, MtCuA O1 and MtP A O3 tran- scr ipt lev els w ere higher in these plants. In roots, transcr ipt le v els of CuA Os w er e slightly lo w er in 25 mM NH 4 + -fed plants, except for MtCuA O3 and MtCuA O5 , which w er e higher in compar ison to plants g r o wn under 25 mM NO 3 – ; the same patter n w as also obser v ed for MtP A O4 ( Fig. 9B ). Exogenous supplementation with Put improved biomass accumulation under NH 4 + nutrition The g r o wth of M. truncatula plants in the pr esence of NH 4 + appear ed str ongly reduced compar ed with the g r o wth in the pr esence of NO 3 – . Indeed, biomass pr oduction in NH 4 + -fed plants w as lo w er than that in NO 3 – -fed plants. At lo w dose , NH 4 + -fed plants had 34% and 29% lo w er shoot ( Fig. 11A ) and r oot ( Fig. 11B ) dr y biomass, r especti v ely , than NO 3 – - -fed plants. At high dose , the decrease in the dry biomass of NH 4 + -fed plants r elati v e to NO 3 – -fed plants w as 40% in shoots and 51% in r oots. The addition of Put to the NH 4 + - containing medium alle viated the r eduction in plant g r o wth Fig. 3. Effect of dif ferent sources and concentrations of N nutrition on the content of the polyamines Put (A), Spd (B), and Spm (C) in shoots and roots of 14-day-old M. truncatula seedlings. Data r epresent means ±SE values ( n =3). Differ ent letters denote statistically significant differences at P <0.05. Fig. 4. Effect of dif ferent sources and concentrations of N nutrition on ADC (A) and ODC (B) enzymatic activity in shoots and roots of 14-day-old M. truncatula seedlings. The enzymatic activity is expressed in enzyme units min –1 mg –1 protein. Arg was used as substrate in the ADC assay , while Orn was used as the substrate for ODC activity . Data repr esent means ±SE values ( n =3–4). Differ ent letters denote statistically significant differ ences at P <0.05. Downloaded from https://academic.oup.com/jxb/article/73/16/5581/6591323 by UNIVERSIDAD DEL PAIS VASCO user on 27 September 2022 Cop y edited b y: OUP Page 5588 of 5595 | Urra et al. ( Fig. 11C ), wher eas it did not affect plant g r o wth when added to the NO 3 – -containing n utr ient solution. The effect of Put in plants g r o wn in NH 4 + -containing medium w as obser v ed at both shoot and r oot le v els, as sho wn by meas - ur ing shoot and r oot dr y w eight ( Fig. 11 ). Adding Put to the g r o wth medium induced a similar effect on plant biomass than that of 1 mM NO 3 – supplementation in the nutr ient solution. As Put at 0.5mM repr esented an additional 1 mM of N supplemented to the plant, w e included a 2mM NH 4 + contr ol. The Put treatment differ ed fr om both the 1 mM and 2 mM NH 4 + contr ols, so the positiv e effect of Put w as not due to an incr ease in N fer tilization ( Fig. 11 ; Supplementar y Fig. S4 ). Discussion The accumulation of urea cycle intermediates and Put in M. truncatula plants under NH 4 + nutrition relates to cation homeostasis and C/N regulation The accumulation of NH 4 + is consider ed to be the main bi- omark er of NH 4 + to xicity ( González-Mor o et al. , 2021 ) , obser v ed in pea ( Ar iz et al. , 2011 ) lettuce , spinach, lupine ( Cr uz et al. , 2006 ), tomato ( V ega-Mas et al. , 2017 ), wheat ( V ega-Mas et al. , 2019 ) , A. thaliana ( Sarask eta et al. , 2016 ), and also for M . truncatula plants subjected to high NH 4 + conditions compar ed with NO 3 – -fed plants ( Fig. 1 ). Ev en though NH 4 + -fed M. trun- catula plants sho w ed the ionic imbalance pr e viously r eco gnized as the main cause of NH 4 + to xicity ( Br itto and Kr onzuck er , 2002 ; Esteban et al. , 2016a ), they w ere ab le to counterbalance K + homeostasis under NH 4 + str ess conditions in both shoots and r oots. Hence , the maintenance of K + homeostasis ma y be link ed to a g r eater tolerance to w ards NH 4 + str ess ( Zhang et al. , 2021 ), as pr e viously obser v ed in pea plants, which r e v er se the NH 4 + to xicity when transfer r ed to high-ir radiance condi- tions ( Ar iz et al. , 2011 ). P ea plants g r o wn under high NH 4 + and high ir radiance r ecei v ed a pr o vision of extra C , tr igger ing an ameliorated r esponse to NH 4 + str ess b y decreasing the Arg pool and incr easing Put content, compar ed with lo w-ir radi- ance-tr eated plants ( Ar iz et al. , 2013 ). Thus, the accumulation of Arg in high-NH 4 + -fed M. truncatula plants ( Fig. 2 ) ma y be a r esponse to limited C a v ailability , as obser v ed in plants g r o wn under lo w ir radiance ( Ar iz et al. , 2013 ) . H owe ve r, M. truncatula plants sho w ed the incr ease in Put content ( Fig. 3 ) that w as pr e viously associated with the tolerance r esponse to NH 4 + in high-ir radiance-tr eated plants ( Ar iz et al. , 2013 ). The channeling of sur plus N into amino acids ( Supple- mentar y Fig. S1 ), par ticularly the urea-cycle metabolites with lo w C/N ratio such as Gln, Arg, Or n, and Put, in shoots and r oots of M. truncatula seedlings g r o wn in high NH 4 + ( Fig. 2 ; Supplementar y Fig. S2 ) re v eals a mechanism of N redistr ib u- tion to cope with high-NH 4 + conditions. The sequestration of NH 4 + excess into lo w C/N molecules such as Arg, which is the amino acid with the lo w est C/N ratio and a major Put pr ecur sor , helps plant cells to maintain the endo genous NH 4 + content belo w to xic le v els ( Ueda et al. , 2008 ). In addition, the a v ailability of C pr o vided by se v eral anapler otic r eactions is also consider ed cr itical in legumes ( Ar iz et al. , 2013 ) and cer eal plants ( V ega-Mas et al. , 2019 ). Ther efore , there is e vidence that the ur ea cycle is a lik ely C/N regulator y contr ol point under NH 4 + str ess as it r epr esents an NH 4 + sink, as w ell as a connec- tion betw een C and N metabolism ( Esteban et al. , 2016a ). Enhanced tolerance to abiotic str ess is usually accompanied b y increased contents of P As in conditions such as salinity , dr ought, and lo w/high temperature ( Alcázar et al. , 2010 ; W ang et al. , 2019 ), and also under NH 4 + str ess ( Belastegui-Macadam et al. , 2007 ). Unlik e other stress conditions, wher e Spd and/or Spm ha v e been reported to pr imar ily accumulate ( Alcázar et Fig. 5. Effect of dif ferent sources and concentrations of N nutrition on Put-dependent CuAO (A), Spd-dependent P AO (B), and Spm-dependent P AO (C) enzymatic activity in shoots and roots of 14-day-old M. truncatula seedlings. The enzymatic activity is expressed in enzyme units min –1 mg –1 protein. Put was used as the substrate in the CuAO assay (A), while Spd (B) or Spm (C) were used as substrates for P AO activity . Data repr esent means ±SE values ( n =3). Differ ent letters denote statistically significant differ ences at P <0.05. Downloaded from https://academic.oup.com/jxb/article/73/16/5581/6591323 by UNIVERSIDAD DEL PAIS VASCO user on 27 September 2022 Cop y edited b y: OUP Ur ea cycle and polyamine metabolism during NH 4 + str ess | Page 5589 of 5595 al. , 2010 ; W ang et al. , 2019 ), our data indicate that high NH 4 + content induced an incr ease in Put and, to a lesser extent, Spd, but it did not affect the Spm content in M. truncatula r oots ( Fig. 3 ). This obser v ation is consistent with the r ecently pro- posed adapti v e r ole that Put ma y pla y under K + deficiency conditions ( Cui et al. , 2020 ), b y contr olling ion channels and H + -A TP ases ( P ottosin et al. , 2021 ), and it ma y w ell explain pr e- vious r esults of studies of plants subjected to NH 4 + str ess. Thus, it w as descr ibed that high ir radiance induced the synthesis of Put in high-NH 4 + -fed pea plants ( Ar iz et al. , 2013 ), which maintained or e v en impr o v ed the inter nal K + content in both shoots and r oots ( Ar iz et al. , 2011 ). The role of the urea cycle in connection to P A metabolism Put has been r e v ealed as an essential metabolite in plant re- sponse to str ess conditions ( Cui et al. , 2020 ). Indeed, the ac- ti vities of enzymes in v olv ed in either Put biosynthesis ( Fig. 4 ) or Put catabolism ( Figs 5 , 6 ) w ere affected b y NH 4 + . In other types of abiotic str ess, Put accum ulation r esulted fr om enhanced ADC expression ( Alcázar et al. , 2010 ). Regarding the synthesis of Put in NH 4 + -fed plants, our data sho w ed a s witch in the functioning of the ur ea cycle in r oots of NH 4 + - fed fr om the ADC to the ODC pathw a y ( Fig. 4 ). It seems that this s witch to ODC acti vity is a character istic of NH 4 + str ess in legumes, as the incr ease in Put in so ybean seedlings under NH 4 + has been also r epor ted using radiolabeled Or n ( Le Rudulier and Goas, 1977 ). Indeed, González-Her nández et al. (2022) r ecently suggested a r ole for the ODC pathw a y in the NH 4 + tolerance r esponse of tomato plants, since plants o v er expr essing ODC sho w ed impr o v ed g r o wth parameter s. In- ter estingly , the NH 4 + -sensiti v e A. thaliana does not possess its o wn ODC gene ( Hanfr ey et al. , 2001 ), which suggests that the ODC enzyme ma y pr o vide g reater plasticity to plants to cope with NH 4 + str ess. Fig. 7. Effect of dif ferent sources and concentrations of N nutrition on H 2 O 2 content in shoots and roots of 14-day-old M. truncatula seedlings. Data repr esent means ±SE values ( n =3). Different letters denote statistically significant differ ences at P <0.05. Fig. 6. Inhibitor constant ( K i ) of NH 4 + on CuAO activity in extracts of M. truncatula shoots (A, B) and roots (C, D) gr own under 1mM NO 3 – for 14 days. Michaelis–Menten plots were obtained using Put as the substrate and NH 4 + as an inhibitor (A, C). Maximum rate ( V max ) and Michaelis constant ( K m ) ar e plotted against the concentration of inhibitor from 0 to 100mM NH 4 + (B, D). Data r epresent means ±SE values ( n =3). Downloaded from https://academic.oup.com/jxb/article/73/16/5581/6591323 by UNIVERSIDAD DEL PAIS VASCO user on 27 September 2022 Cop y edited b y: OUP Page 5590 of 5595 | Urra et al. Regar ding the gene expr ession le v els, except for MtCPSII1 in r oots, all the urea-cycle genes w ere induced dur ing high- NH 4 + conditions in both shoots and r oots ( Fig. 9 ). The r e - markable incr ease in transcr ipt lev els of MtADC1 , MtADC2 , and MtODC in shoots, and MtADC2 and MtODC in r oots, highlighted the r ele v ance of the interconnection betw een the ur ea cycle and P A metabolism. The str ong increase in ADC transcr ipt lev els in M. truncatula plants g r o wn under NH 4 + nutr ition contrasted with the decrease in ADC ac - ti vity . This suggests the existence of post-transcr iptional r egulator y mechanisms as the descr ibed regulation of the ADC enzymes b y upstream open r eading frames ( Jiménez- Br emont et al. , 2022 ). Ho w ev er , w e cannot exclude that the r eaction catalyzed b y ADC w as affected b y the follo wing AIH and NCP AH acti vities, as both r elease NH 4 + . In an y case , the impor tance of the pathw a y has also been r eflected in ODC -silencing tomato plants under NH 4 + nutr ition, which r equir ed compensation b y ADC induction. Fur - ther more , both ADC -silencing and ODC -o v er expr essing mutants sho w ed amelioration of NH 4 + to xicity syndr ome ( González-Her nández et al. , 2022 ). Regar ding P A catabolism, the lo w er total acti vities of the CuA Os confir med the deceleration of the Put catabolic reac- tions at a high NH 4 + dose ( Fig. 5 ), and e videnced the existence of a feedback inhibitor y mechanism of CuA O by NH 4 + ( Fig. 6 ), as pr oposed in Esteban et al. (2016a) . Accor dingly , exo ge- nous GAB A has been sho wn to alle viate h ypo xia ( W ang et al. , 2014 ) and dr ought damage ( Y ong et al. , 2017 ) b y inducing P A accumulation as w ell as pre v enting P A deg radation, which sup- por ts a feedback regulation of CuA O activity . Ther efore , the incr ease of Put in high-NH 4 + -fed plants ma y be attr ibuted to an incr ease in ODC acti vity and a reduction in CuA O activity as the cellular NH 4 + content incr eases ( Fig. 8 ). In contrast to the ur ea-cycle genes, the transcr ipt le v els of the P A-catabolism genes sho w ed a general decr ease , except for MtCuA O1 and MtP A O3 in shoots, and MtCuA O3 and MtP A O4 in r oots ( Fig. 9 ). In accordance with the r educed CuA O acti vity obser v ed in 25 mM NH 4 + -fed plants, the transcr iptional analysis sho w ed that high NH 4 + conditions decr eased the pr edicted apoplastic MtCuA O2 and MtCuA O7 in shoots, while the pr edicted apoplastic MtCuA O3 w as up- r egulated in r oots of NH 4 + -fed plants in compar ison to plants Fig. 8. The urea cycle and P A metabolism in plants. Enzymes are r epresented in bold text, and metabolites in r egular text (after Esteban et al. , 2016a ). Changes, when comparing NH 4 + versus NO 3 – nutrition, are depicted in gr een when either metabolite content or enzymatic activity decreased, and in red when they increased. Shoot and r oot tissues are repr esented by the upper and lower squares, respectively . Illustration created with BioRender 2022. Downloaded from https://academic.oup.com/jxb/article/73/16/5581/6591323 by UNIVERSIDAD DEL PAIS VASCO user on 27 September 2022 [Document text truncated for crawler view.]