STUDY OF THE RHEOLOGY OF THE PASTE "UROKONIT-MR"

169 Volume 5, Issue 10: Special Issue (EJAR) ISSN: 2181-2020 MPHAPP THE 6TH INTERNATIONAL SCIENTIFIC AND PRACTICAL CONFERENCE “MODERN PHARMACEUTICS: ACTUAL PROBLEMS AND PROSPECTS” TASHKENT, OCTOBER 17, 2025 in-academy.uz STUDY OF THE RHEOLOGY OF THE PASTE “UROKONIT-MR” M.M.Rakhmatullayeva Tashkent Pharmaceutical Institute, Tashkent, Republic of Uzbekistan е-mail: [email protected] https://doi.org/10.5281/zenodo.17328806 Relevance: Kidney and urinary system diseases of various etiologies occupy an important place in the general structure of the population's morbidity. Along with synthetic drugs, herbal preparations are also widely used for their treatment. An extract was obtained on the basis of hairy erva grass, nettle leaves, common goldenrod, bird's foot, cornflower mouth and column, onion peel, SilicaHorsetail-equisetum arvense, birch leaves. Glycerin, wheat starch, vanillin, monodistilled fatty acids (emulsifier E 471) were used as excipients. "Uroconit-MR" paste was prepared. The purpose of the study: to study the rheological properties of the paste "UROKONIT-MR". Methods and techniques: The experiments were carried out on the Reotest-2 device using a cell consisting of a system of S/S1 cylinders with a Z( (constant) = 5.8. The indicator of the device was carried out in mode 1 (at 25, 40, 55oC) at a constant temperature of different numbers. Before performing the experiment, the paste was thoroughly mixed so that there were no voids and bubbles in the paste. The paste was placed in special glass jars and thermostated at a specified temperature (25, 40, 55 oC) ± 2 oC for 2 hours. The saturated shear stress of the system τ = ·Z, gradient velocity (γ), effective viscosity (η) and logarithm of effective viscosity were determined. Results: The saturated shear stress (τ = a•Z), gradient velocity (γ), effective viscosity of the “UROKONIT-MR” paste at different temperatures The results of the logarithm of (η) and effective viscosity are presented in the table. As can be seen from the table, the shear stress decreases sharply with increasing temperature. This indicates that the activation energy of viscous flow decreases, and as a result, the effective viscosity also decreases. When the gradient velocity is small, the viscosity is high, and when the temperature increases from 250С to 550С, its value decreases. Therefore, the structure of the system is destroyed. As the velocity gradient increases, the viscosity decreases to a minimum, that is, the structure of the paste is completely destroyed. Conclusions: In the process of studying the rheological properties of the paste, the saturated shear stress, gradient velocity, effective viscosity and logarithm of effective viscosity at different Асбоб кўрсаткичи Siljishi kuchlanishi ,  = *Z, Pа Tezligi gradienti, , с-1 Effektiv qovushqoqlik , ηeff. =  / , Pа.с Effektiv qovushqoqlik logarifmi, lnηeff., Pа.с № α 25оС 40оС 55оС 25оС 40оС 55оС 25оС 40оС 55оС 25оС 40оС 55оС 1а 8 46,4 11,6 5,8 3,0 3,0 3,0 15,4 3,8 1,9 2,73 1,33 0,64 2а 8 46,4 17,4 5,8 5,4 5,4 5,4 8,59 3,2 1,07 2,15 1,16 0,06 3а 9 52,2 17,4 5,8 9,0 9,0 9,0 5,8 1,9 0,64 1,75 0,64 -0,44 4а 10 58 23,2 11,6 16,2 16,2 16,2 3,58 1,43 0,71 1,27 0,35 -0,34 5а 13 75,4 23,2 11,6 27,0 27,0 27,0 2,79 0,85 0,42 1,02 -0,16 -0,86 6а 16 92,8 29 11,6 48,6 48,6 48,6 1,9 0,59 0,23 0,64 -0,52 -1,46 7а 20 116 29 17,4 81,0 81,0 81,0 1,4 0,35 0,21 0,33 -1,04 -1,56 8а 28 162,4 46,4 17,4 145,8 145,8 145,8 1,1 0,31 0,11 0,09 -1,17 -2,20 9а 41 237,8 75,4 23,2 243 243 243 0,97 0,31 0,09 -0,03 -1,17 -2,4 10а 54 313,2 139,2 46 437,4 437,4 437,4 0,71 0,31 0,09 -0,34 -1,17 -2,4 11а 67 388,6 243,6 69,6 729 729 729 0,53 0,33 0,09 -0,63 -1,1 -2,4 12а 84 487,2 440,8 116 1312 1312 1312 0,37 0,33 0,08 -0,99 -1,1 -2,52 170 Volume 5, Issue 10: Special Issue (EJAR) ISSN: 2181-2020 MPHAPP THE 6TH INTERNATIONAL SCIENTIFIC AND PRACTICAL CONFERENCE “MODERN PHARMACEUTICS: ACTUAL PROBLEMS AND PROSPECTS” TASHKENT, OCTOBER 17, 2025 in-academy.uz temperatures were determined. Analysis of the results obtained showed that "Uroconit-MR" is a system that does not obey Newton's law.