SYNTHESIS OF MEDICINES BASED ON THE COORDINATION COMPOUND OF Zn(II) WITH GLUTARIC AND NICOTINIC ACIDS

328 Volume 5, Issue 10: Special Issue (EJAR) ISSN: 2181-2020 MPHAPP THE 6TH INTERNATIONAL SCIENTIFIC AND PRACTICAL CONFERENCE “MODERN PHARMACEUTICS: ACTUAL PROBLEMS AND PROSPECTS” TASHKENT, OCTOBER 17, 2025 in-academy.uz SYNTHESIS OF MEDICINES BASED ON THE COORDINATION COMPOUND OF Zn(II) WITH GLUTARIC AND NICOTINIC ACIDS Gazieva A.S. Fathullaeva M. Tashkent Pharmaceutical Institute, Tashkent city, Republic of Uzbekistan e-mail: [email protected] https://doi.org/10.5281/zenodo.17337016 Chronic deficiency of the trace element zinc is known to lead to immunodeficiency. Zinc is an effective immunostimulant. Zinc is present in all internal organs, tissues, fluids, and almost 100% of the body's enzymatic systems. Zinc acts as a "secondary mediator" of immune cells and significantly shortens the duration of inflammation. When a person catches a cold, a large amount of zinc is consumed in the first few hours, and the need for it increases 6-8 times. Zinc has anti-inflammatory, antioxidant, and antibacterial properties. Zinc reduces susceptibility to acute lower respiratory tract infections. Zinc ions stimulate the production of endogenous αand γ-interferons, which also exert antiviral activity, including against COVID-19. Based on the above, a targeted synthesis and study of the physicochemical properties of a mixed-ligand coordination compound of Zn(II) with bioligands—glutaric (GLA) and nicotinic (NA) acids—was conducted. Zinc nitrate and sodium hydroxide of analytical grade were used in this study. The ligands were glutaric (GLA) and nicotinic (NA) acids of pharmacopoeial grade. The isolated compound was analyzed for metal content using complexometric methods. The melting point of the resulting complex was determined using a TU-25 apparatus. To establish the purity and identity of the obtained complex, X-ray diffraction patterns were recorded using a DRON-2.0 setup with a copper anticathode. IR spectra were recorded using a PERKIN-ELMER FTIR spectrophotometer in the 4004000 cm-1 range. Thermal analysis was performed using a F. Paulik, J. Paulik, and L. Erdey derivatograph (MOM, Hungary). Synthesis of Zn(GLK-2H)(NK)∙2H2O: 0.006 mol NaOH and 0.006 mol NK were dissolved in 5 ml of water. A solution of 0.006 mol NaOH and 0.006 mol (GLK) in 5 ml of water was added to the sodium salt of NK. When 0.006 mol of an aqueous solution of Zn(NO3)2 was added to the ligand solution, a precipitate formed, which was stirred on a magnetic stirrer for two days. The precipitate was filtered and washed several times with water and ether. The composition and some physicochemical properties of the synthesized complex compound are given in Tables 1 and 2. Table 1. Elemental analysis results for the synthesized complex compound Compound Found, % Calculated, % М N H2O M N H2O Zn(GLK-2H)(NK)∙2H2O 19,20 4,13 7,96 19,15 4,10 7,91 Table 2. Some physicochemical properties of the synthesized complex compound Compound Color Mel.poin t, 0С Yield, % Solubility, g/100g water Zn(GLK-2H)(NK)∙2H2O White 248 78 insol. 329 Volume 5, Issue 10: Special Issue (EJAR) ISSN: 2181-2020 MPHAPP THE 6TH INTERNATIONAL SCIENTIFIC AND PRACTICAL CONFERENCE “MODERN PHARMACEUTICS: ACTUAL PROBLEMS AND PROSPECTS” TASHKENT, OCTOBER 17, 2025 in-academy.uz A new zinc biocomplex was synthesized. IR spectroscopy and thermal analysis revealed that succinic and nicotinic acids coordinate to the metal bidentately in the deprotonated form.