CarDia National Institute Annual Meeting

Programme Thursday 09. 10. 2025 08:30 – 08:50 REGISTRATION WELCOME COFFEE 08:50 – 09:00 Martin Haluzík: Opening 09:00 – 10:30 WP4 09:00 – 09:15 Karol Čurila: Individualization of treatment in patients with indications for resynchronization therapy (3FM CU) 09:15 – 09:30 David Sedmera: Arrhythmogenic substrate in rat models of heart failure (1FM CU) 09:30 – 09:45 Martin Pešl: Diabetic Cardiomyopathy as a Stem and Progenitor Cell Disorder (MUNI) 09:45 – 10:00 Predrag Stojadinovič: MRI assesment of vital organ perfusion during atrial fibrillation 10:00 – 10:15 WP4 Summary (David Sedmera, 1FM CU, Josef Kautzner, IKEM) 10:15 – 10:30 Michaela Tencerová: Bone marrow fat: a hidden player in health and disease (WP2; IPHSYS) 10:30 – 10:45 COFFEE BREAK 10:45 – 12:15 WP1 10:45 – 11:00 Lenka Rossmeislová: Adiposity, Age, or Acute Exercise: What does affect the FAHFA Levels in Healthy Women? (3FM CU) 11:00 – 11:15 Michal Pravenec: Integrative metabolomic and genetic mapping for identification of genes regulating liver metabolism and blood pressure in the HXB/BXH rat panel (IPHYS) 11:15 – 11:30 Lydie Plecita-Hlavatá: Pancreatic β-Cell Redox Signaling: A Double-Edged Sword (IPHYS) 11:30 – 11:45 Kateřina Kaňková: The associations of maternal liver and lipid biomarkers in pregnancy with gestational diabetes and adverse pregnancy outcomes (MUNI) 11:45 – 12:00 Jan Gojda: Omics signatures of plant-based diets and their potential to predict remission of diabetes (3FM CU) 12:00 – 12:15 WP1 Summary (Michal Pravenec, IPHYS and Kateřina Kaňková, MUNI) 12:15 – 13:15 LUNCH 13:15 – 13:45 E-POSTERS 13:4515:15 WP5 13:45 – 14:00 Karolína Motílová: Comparison of left ventricular function recovery in diabetic and non-diabetic patients with RODCM (MUNI) 14:00 – 14:30 Keynote Lecture (on-line): Barry A. Borlaug: Obesity and Heart Failure: from mechanisms to therapies (Mayo Clinic, United States) 14:30 – 14:45 Ondřej Kuda: Adipose tissue lipid remodeling in heart failure (IPHYS) Programme 14:45 – 15:00 Matúš Miklovič: A New Dual-Hit Rat Model of Type 2 Pulmonary Hypertension in Ischemic Heart Failure (IKEM) 15:00 – 15:15 WP5 Summary (Vojtěch Melenovský, IKEM and František Kolář, IPHYS) 15:15 – 15:30 COFFEE BREAK 15:30 – 17:00 WP6 15:30 – 15:45 Jan Piťha: The role of sex, reproductive age, and (pre)diabetes in the development and progression of cardiovascular diseases (IKEM) 15:45 – 16:00 Lukáš Kubala: Overview of Mechanism of Microbiome Action in the Development of Inflammation and Atherosclerosis (MUNI) 16:00 – 16:15 Jiří Nováček: Molecular mechanism of IGF-1 receptor and insulin receptor interaction with a panel of hormonal mimetics (MUNI) 16:15 – 16:30 Tomáš Freiberger: Study of monogenic and polygenic determination of atherosclerosis (MUNI) 16:30 – 16:45 Petr Kala: New methods for the detection of preclinical atherosclerosis and new approaches to antithrombotic therapy and the prevention of atherothrombosis (MUNI) 16:45 – 17:00 WP6 Summary (Tomáš Freiberger, MUNI and Petr Kala, MUNI) 17:00 – 17:30 E-POSTERS 17:30 – 19:00 NETWORKING & REFRESHMENTS Friday 10. 10. 2025 08:00 – 08:30 WELCOME COFFEE 08:30 – 10:30 WP2 08:30 – 08:45 Tomáš Mráček: COX6B1 secures a redox-sensitive step in early cytochrome c oxidase assembly (IPHYS) 08:45 – 09:00 Alena Pecinová: Sequestration of the Polyunsaturated Fatty Acids Protects the Cells with Oxidative Phosphorylation Deficiency from Ferroptosis (IPHYS) 09:00 – 09:15 Jiří Paleček: Decoding the Inflammatory Lipidome in Painful Diabetic Neuropathy (IPHYS) 09:15 – 09:30 Jiří Jiráček: Development and testing of new selective insulin analogs (IOCB) 09:30 – 09:45 Lenka Maletínská: Stable lipidized analogs of neuropeptides for treatment of obesity and type 2 diabetes (IOCB) 09:45 – 10:00 Martin Vokurka: SGLT2 inhibitors and urine extracellular vesicles proteins in heart failure patients with reduced ejection fraction (1FM CUNI) 10:00 – 10:15 Soňa Štemberková Hubáčková: Senolytic therapy in MASH: a potential strategy for reducing fibrosis and preventing hepatocellular carcinoma (IKEM) 10:15 – 10:30 WP2 Summary (Lenka Maletínská, IOCB and Martin Haluzík, IKEM) Programme 10:30 – 10:40 COFFEE BREAK 10:40 – 12:10 WP3 10:40 – 10:55 Tomáš Čajka: N-Lactoyl-amino acids identified by untargeted metabolomics track metformin use and adherence in type 2 diabetes (IPHYS) 10:55 – 11:20 Jakub Sikora: Recently identified rare hereditary amyloidoses - genetic causes and therapy (1 FM CU) 11:20 – 11:40 Klára Svojšová: "α-Galactosidase A Misprocessing-Induced Unfolded Protein Response: Lysosomal Storage-Independent Mechanism of Fabry Disease Pathogenesis (1 FM CU) 11:40 – 12:00 Lenka Piherová: Rapid integrative diagnostics in cardiogenetics (1 FM CU) 12:00 – 12:10 WP3 Summary (Jakub Sikora, 1 FM CU and Tomáš Čajka, IPHYS) 12:10 – 13:00 LUNCH 13:00 – 13:30 E-POSTERS 13:30 – 15:15 WP7 13:30 – 13:45 Lucie Bačáková: A Pre-Vascularized Tissue-Engineered Construct for Vascular Wall Reconstruction (IPHYS) 13:45 – 14:00 Jaroslav Chlupáč: Overview of vascular surgery activities within the CarDia project (IKEM) 14:00 – 14:15 Peter Girman: Intrarenal Transcriptomic Signatures of Donor Diabetes and Their Normalization After Kidney Transplantation (IKEM) 14:15 – 14:30 Petr Ježek: Development of liraglutide-conjugated nanoparticle contrast agents for estimation of pancreatic beta cell mass in vivo (IPHYS) 14:30 – 14:45 David Habart: IsletNet: web service for automatic image analysis with highly accurate model for islet volume islet estimation before transplantation (IKEM) 14:45 – 15:00 Elena Filová: Nanofibers modified with platelet lysate for chronic wound healing (IPHYS) 15:00 – 15:15 WP7 Summary (Jan Kříž, IKEM and Ondřej Viklický, IKEM) 15:15 – 15:30 CLOSING REMARKS 15:30 – 16:30 COFFEE BREAK & NETWORKING