HERBAL REMEDIES IN THE TREATMENT OF ANTI-ULCER DRUGS

476 Volume 5, Issue 10: Special Issue (EJAR) ISSN: 2181-2020 MPHAPP THE 6TH INTERNATIONAL SCIENTIFIC AND PRACTICAL CONFERENCE “MODERN PHARMACEUTICS: ACTUAL PROBLEMS AND PROSPECTS” TASHKENT, OCTOBER 17, 2025 in-academy.uz HERBAL REMEDIES IN THE TREATMENT OF ANTI-ULCER DRUGS Sultanova R.Kh.1 F.D. Kulboeva1 A. Kholboev2 1Tashkent Pharmaceutical Institute, Tashkent city, Republic of Uzbekistan 2Tashkent Medical University, Tashkent city, Republic of Uzbekistan https://doi.org/10.5281/zenodo.17342724 Relevance: Peptic ulcer disease (PUD) holds a special place among chronic diseases of the gastrointestinal tract due to its prevalence and severity. We know that in most cases, synthetic drugs are taken which have a pronounced pharmacotherapeutic effect. However, they also have side effects on other functional organs. This limits their possible use in some cases (for children and pregnant women) as well as for individual intolerance to synthetic drugs. In this regard, the use of medicinal plants with anti-ulcer effects is relevant. Objective. The main objective of the work is to determine a list of reliable and proven medicinal plants against gastric and duodenal ulcers, as well as to highlight their chemical composition. Materials and Methods. Internet resources based on publications in PubMed. Results. Examples of plants and their components mentioned in publications on PubMed: Licorice root (Glycyrrhiza glabra): The main active components are glycyrrhizin (glycyrrhizic acid), as well as flavonoids (liquiritin, isoliquiritin) and triterpene saponins. Glycyrrhizin stimulates the production of a protective mucus in the stomach and inhibits enzymes that can cause inflammation. Flavonoids have antispasmodic and antibacterial effects, including against Helicobacter pylori. Sea buckthorn (Hippophae rhamnoides): Sea buckthorn oil is rich in omega-3, -6, -7, and -9 fatty acids, as well as vitamins A, E, C, and carotenoids. Fatty acids, especially omega-7, promote the regeneration and healing of mucous membranes. Vitamins and carotenoids act as powerful antioxidants, protecting cells from damage and accelerating tissue repair. Greater plantain (Plantago major): Contains polysaccharides, mucilage, the glycoside aucubin, and tannins. Polysaccharides and mucilage form a protective film on the surface of the ulcer, enveloping it and reducing irritation. Aucubin exhibits antibacterial properties, while tannins have an astringent effect, which helps reduce inflammation and stop micro-bleeding. Chamomile (Matricaria chamomilla): Essential oil with the main components chamazulene and α-bisabolol, as well as the flavonoid apigenin. Chamazulene and α-bisabolol have strong anti-inflammatory and antispasmodic effects. Apigenin has a relaxing effect on the stomach muscles, relieving pain and spasms. Ginger (Zingiber officinale): Contains gingerols and shogaols, as well as essential oils. Gingerols and shogaols have antioxidant and anti-inflammatory effects. They can also inhibit the growth of the bacterium Helicobacter pylori, which helps eliminate one of the main causes of peptic ulcer disease. Despite numerous studies on medicinal plants, their effectiveness and safety in the treatment of PUD must be confirmed by large-scale, randomized clinical trials in humans to be recommended as a primary treatment method. Currently, phytotherapy is more often considered an auxiliary or additional method rather than a substitute for traditional medications with proven effectiveness (PPIs, antibiotics). Conclusion. The study of medicinal plants in the treatment of peptic ulcer disease (PUD) is a rapidly developing field in pharmacology, as indicated by the PubMed database. Therefore, it can be said that the above-mentioned medicinal plants are of great interest in medicine and pharmacy.