Bioresorbable and Wireless rechargeable implanted Na-ion Battery for Transient Medical Devices

Department of Flexible Electronics INSPIRING INNOVATION SINCE 1816 Bioresorbable and Wireless rechargeable implnated Na-ion Battery for Transient Medical Devices Thierry Djenizian 25 June 2025 Department of Flexible Electronics •Provide a targeted and personalized therapy during a determined clinical time •Therapy: localized drug release, electrical stimulation, biosensing and monitoring,… •Future technology: TMI should be entirely bioresorbable to avoid a second surgery Interest in temporary medical implants (TMI) DBS for stroke recovery and nerve regeneration by electrode stimulation Drawback: powered by implanted permanent batteries Bioresorbable battery Department of Flexible Electronics Ø Bioresorbable TMIs need efficient transient energy systems Rechargeable battery technologies including Li-ion batteries are using toxic elements that cannot be safely degraded by the body and must be then removed by surgery and recycled after use Ø A rechargeable wearable power source in which all constituents are non-toxic and able to be degraded by physiological fluids have not been achieved yet Propose a new technology able to penetrate the biomedical market and revolutionize the bioresorbable electronics The main challenges Our successful achievement: Design a high performance battery that is implantable, bioresorbable, wireless rechargeable with a controlled lifetime (from days to several months) T. Djenizian, et al., A Na-ion bioresorbable and flexible electrochemical accumulator. Patent # EP23170468.5, 2023 Bioresorbable battery Department of Flexible Electronics Wireless charging of implanted battery The main concept of the Na-ion battery Bioresorbable battery Department of Flexible Electronics An alternative fabrication process Bioresorbable battery T. Djenizian, et al., A Na-ion bioeliminable electrochemical accumulator comprising electrode pellets coated by a current collector thin film, Associated manufacturing process and wireless recharging solution. Patent #EP24306269.2., 2024. Department of Flexible Electronics Current collectors: Mg Anode: NTP-C, carbon black, sodium alginate Cathode: NMO, carbon black, sodium alginate Polymer electrolyte: Sodium sulfate, sodium alginate Bioresorbable battery V. Muniraj, B. L. Vijayan, H. Hammoud, R. Delattre, M.Ramuz, E. Djenizian, E. Vandini, D. Giuliani, T. Djenizian, Bioresorbable and Wireless Rechargeable Implanted Na-ion Battery for Temporary Medical Devices, Adv. Funct. Mater., 2417353 (2025). Department of Flexible Electronics Electrochemical characterizations and KPIs Main features Diameter 0.74 cm Thickness 0.12 cm Surface 0.43 cm2 Volume 0.05 cm3 Mass 90 mg Bio-elimination time One day –several months Key Performance Indicators @C/2rate 1st discharge capacity 1.2 mAh Capacity retention 83 % after 50 cycles Energy 0.78 mWh Power 1.17 mW Wireless recharging characteristics Recharge at 4 mm 30 min Recharge at 12 mm 1 h Bioresorbable battery V. Muniraj, B. L. Vijayan, H. Hammoud, R. Delattre, M.Ramuz, E. Djenizian, E. Vandini, D. Giuliani, T. Djenizian, Bioresorbable and Wireless Rechargeable Implanted Na-ion Battery for Temporary Medical Devices, Adv. Funct. Mater., 2417353 (2025). Department of Flexible Electronics In vitro studies of bare batteries Bioresorbable battery V. Muniraj, B. L. Vijayan, H. Hammoud, R. Delattre, M.Ramuz, E. Djenizian, E. Vandini, D. Giuliani, T. Djenizian, Bioresorbable and Wireless Rechargeable Implanted Na-ion Battery for Temporary Medical Devices, Adv. Funct. Mater., 2417353 (2025). Department of Flexible Electronics In vivo studies of bare batteries Bioresorbable battery V. Muniraj, B. L. Vijayan, H. Hammoud, R. Delattre, M.Ramuz, E. Djenizian, E. Vandini, D. Giuliani, T. Djenizian, Bioresorbable and Wireless Rechargeable Implanted Na-ion Battery for Temporary Medical Devices, Adv. Funct. Mater., 2417353 (2025). üBio-disintegration & elimination Department of Flexible Electronics 16 The main issue Mg(OH)2 𝑀𝑔 +2𝐻20' ⟶ 𝑀𝑔 𝑂𝐻 2+ 𝐻2 Increase of the cell resistance due to the oxidation reactions induced by O2 from air and the moisture from the electrolyte Department of Flexible Electronics Bioresorbable battery Current collectors: Mg à Mo Anode: NTP-C, carbon black, Na-CMC Cathode: NMO, carbon black, Na-CMC Polymer electrolyte: Sodium sulfate, Na-CMC (less moisture) Unpublished results Department of Flexible Electronics 18 Last achievements Unpublished results Department of Flexible Electronics 19 Last achievements Mg thin-film is fully oxidized! Department of Flexible Electronics 20 Last achievements Unpublished results Department of Flexible Electronics Thank you