Equal-Life fourth wave scientific papers

This project has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No 874724 1 Equal-Life fourth wave scientific papers Project title: Early Environmental quality and life-course mental health effects Project Number: 874724 Project Acronym: Equal-Life Work package 10 - Deliverable D10.12 HISTORY OF CHANGES Version Publication date Change 1.1 30-06-2025 This project has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No 874724 2 H2020 program Grant agreement numbers 874724 (Equal-Life), Project start date: Jan 1st 2020 Duration: 66 months Project Coördinators: Irene van Kamp (RIVM) WP (number and title) WP10: Management and Dissemination Deliverable Number D10.12 Deliverable Title Fourth wave scientific papers Due date M66 Actual date 30-06-2025 Dissemination Level Public Lead beneficiary RIVM Responsible authors Irene van Kamp E-mail / phone responsible authors Irene van Kamp (RIVM) +31 62 111 2691 Reviewers All PI’s This project has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No 874724 3 Table of Contents 1 Summary ......................................................................................................................................... 4 2 Published papers ............................................................................................................................. 4 3 Papers in preparation ..................................................................................................................... 6 4 Other Publications .......................................................................................................................... 9 5 PhD Theses defended until 30.6.2025 .......................................................................................... 12 This project has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No 874724 4 1 Summary This report gives an overview of the published scientific papers that were published between January 1st 2024 and June 30th 2025 in the context of the Equal-Life project (Chapter 2) and a list of papers per work package (WP) that are in the final stages of preparation in June 2025, to be submitted in 2025 or under review (Chapter 3) and a list of publications aimed at the general public (Chapter 4) and 4) a list of PhD theses (Chapter 5). For the Equal-Life publication policy, we refer to D10.2. All publications will be findable at https://zenodo.org/communities/equal_life, also the publications not mentioned here. 2 Published papers The following scientific papers were published between January 1st 2024 and June 30th 2025 in the context of the Equal-Life project: Peer reviewed articles 1. Afonin, A. M., Piironen, A.-K., De Sousa Maciel, I., Ivanova, M., Alatalo, A., Whipp, A. M., Pulkkinen, L., Rose, R. J., Van Kamp, I., Kaprio, J., & Kanninen, K. M. (2024). Proteomic insights into mental health status: plasma markers in young adults. Translational Psychiatry, 14(1), 55. https://doi.org/10.1038/s41398-024-02751-z 2. Drouard, G., Hagenbeek, F. A., Whipp, A. M., Pool, R., Hottenga, J. J., Jansen, R., Hubers, N., Afonin, A., BIOS Consortium, BBMRI-N. L. Metabolomics Consortium, Willemsen, G., De Geus, E. J. C., Ripatti, S., Pirinen, M., Kanninen, K. M., Boomsma, D. I., Van Dongen, J., & Kaprio, J. (2023). Longitudinal multi-omics study reveals common etiology underlying association between plasma proteome and BMI trajectories in adolescent and young adult twins. BMC Medicine, 21(1), 508. https://doi.org/10.1186/s12916-023-03198-7 3. Drouard, G., Wang, Z., Heikkinen, A., Foraster, M., Julvez, J., Kanninen, K. M., Van Kamp, I., Pirinen, M., Ollikainen, M., & Kaprio, J. (2024). Lifestyle differences between co-twins are associated with decreased similarity in their internal and external exposome profiles. Scientific Reports, 14(1), 21261. https://doi.org/10.1038/s41598-024-72354-7 4. Dzhambov, A. M., Lercher, P., & Botteldooren, D. (2024). Childhood sound disturbance and sleep problems in Alpine valleys with high levels of traffic exposures and greenspace. Environmental Research, 242, 117642. https://doi.org/10.1016/j.envres.2023.117642 5. Jansen, S. N. G., Kamphorst, B. A., Mulder, B. C., Van Kamp, I., Boekhold, S., Van Den Hazel, P., & Verweij, M. F. (2024). Ethics of early detection of disease risk factors: A scoping review. BMC Medical Ethics, 25(1), 25. https://doi.org/10.1186/s12910-024-01012-4 6. Lercher, P., Dzhambov, A. M., & Persson Waye, K. (2025). Environmental perceptions, selfregulation, and coping with noise mediate the associations between children’s physical environment and sleep and mental health problems. Environmental Research, 264, 120414. https://doi.org/10.1016/j.envres.2024.120414 This project has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No 874724 5 7. Milias, V., Psyllidis, A., & Bozzon, A. (2024). Bridging or separating? Co-accessibility as a measure for potential place-based encounters. Journal of Transport Geography, vol. 121, 104027. https://doi.org/10.1016/j.jtrangeo.2024.104027 8. Milias, V., Teeuwen, R., Bozzon, A., & Psyllidis, A. (2024). Crowdsourcing the influence of physical features on the likely use of public open spaces. Computational Urban Science, 4(1), 15. https://doi.org/10.1007/s43762-024-00126-0 9. Seitz, J., & Fels, J. (2025a). Activity-based acoustic situations in primary schools: Analyzing classroom noise and listening effort. The Journal of the Acoustical Society of America, 157(3), 1772–1783. https://doi.org/10.1121/10.0036129 10. Seitz, J., Loh, K., & Fels, J. (2024). Listening effort in children and adults in classroom noise. Scientific Reports, 14(1), 25200. https://doi.org/10.1038/s41598-024-76932-7 11. Teeuwen, R., Bozzon, A., & Psyllidis, A. (2024). Children’s access to urban greenspace: a survey of factors and measures. Cities & Health, 1–21. https://doi.org/10.1080/23748834.2024.2387931 12. Teeuwen, R., Milias, V., Bozzon, A., & Psyllidis, A. (2024). How well do NDVI and OpenStreetMap data capture people’s visual perceptions of urban greenspace? Landscape and Urban Planning, 245, 105009. https://doi.org/10.1016/j.landurbplan.2024.105009 13. Telkmann, K., Gudi-Mindermann, H., Bogers, R., Ahrens, J., Tönnies, J., Van Kamp, I., Vrijkotte, T., & Bolte, G. (2025). Identification of exposome clusters based on societal, social, built and natural environment – results of the ABCD cohort study. Environment International, 197, 109335. https://doi.org/10.1016/j.envint.2025.109335 14. Wang, Z., Drouard, G., Whipp, A. M., Heinonen-Guzejev, M., Bolte, G., & Kaprio, J. (2024). Association between trajectories of the neighborhood social exposome and mental health in late adolescence: A FinnTwin12 cohort study. Journal of Affective Disorders, 358, 70–78. https://doi.org/10.1016/j.jad.2024.04.096 15. Wang, Z., Whipp, A. M., Heinonen-Guzejev, M., Foraster, M., Júlvez, J., & Kaprio, J. (2024). The association between urban land use and depressive symptoms in young adulthood: a FinnTwin12 cohort study. Journal of Exposure Science & Environmental Epidemiology, 34(5), 770–779. https://doi.org/10.1038/s41370-023-00619-w 16. Wang, Z., Whipp, A. M., Heinonen-Guzejev, M., & Kaprio, J. (2024). Age at separation, residential mobility, and depressive symptoms among twins in late adolescence and young adulthood: a FinnTwin12 cohort study. BMC Public Health, 24(1), 2239. https://doi.org/10.1186/s12889-024-19734-w 17. Wang, Z., Aaltonen, S., Teeuwen, R., Milias, V., Peuters, C., Raimbault, B., Palviainen, T., Lumpe, E., Dick, D., Salvatore, J. E., Foraster, M., Dadvand, P., Júlvez, J., Psyllidis, A., van Kamp, I., & Kaprio, J. (2025). The urban physical environment and leisure-time physical activity in early midlife: A FinnTwin12 study. Health & Place, 94, 103495. https://doi.org/10.1016/j.healthplace.2025.103495 These papers are also added to the continuous reporting module in the EC portal. This project has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No 874724 6 3 Papers in preparation The following papers are planned some of which in the final stages of preparation in June 2025 or are currently under review. WP1 Belke, C., Schreckenberg, D., Benz, S., Kuhlmann, J., Dzhambov, A., Lercher, P., Klatte, M., Leist, L., Vincens, N., Persson Waye, K., Jeram, S., Ristovska, G., Spiroski, I., Kanninen, K., Alatalo, A., Selander, J., Eriksson, C., Arati, A., White, K., & van Kamp, I. (n.d.). Stress as a potential mediator in the association between exposome, mental health and cognitive development in children and adolescents: A scoping review. [to be submitted] Klatte, M. Bergström, K.; Leist, L.;. …. & Persson Waye, K. The role of self-regulation in the effects of environmental exposures on child mental health and cognition: A systematic review Klatte, M., Leist, L.; Schreckenberg, D.; et al. Speech-in-noise perception predicts phonological awareness and reading in school starters instructed in German language. Klatte, M., Schreckenberg, D. In-depth studies: school studies longitudinal comparison (German sample) Nele De Poortere, UGent, and all partners involved in in depth study (2025) Impact of exposome on early development of hearing and attention. Angel Dzhambov, Peter Lercher (shared), et al. Reading performance of Alpine schoolchildren in relationship with exposome components - mediation analysis. Natalia Vincens , Kerstin Persson Waye, (shared), WP1 members (2025) Scoping review the impact of exposome on mental health and cognition among children mediated by sleep. (will be delayed until September 2025). Gordana Ristovska/Natalia Vincens, WP1 members (2025) Environmental factors and child cognitive development: a scoping review of exposome research trends. Kerstin Persson Waye, et al. (2025) In-depth studies: An exposome perspective on sleep and mental health among adolescents. Nele Depoortere, Partners in-depth study (2025) Exploring the Multi-Faced Impact of EarlyLife Environmental Sound Exposure at Home on Primary School Children Timothy Van Renterghem, RWTH Aachen?, partners in-depth study (2025) School noise and reverberation and cognitive development of pre-school children This project has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No 874724 7 Angel Dzhambov, Peter Lercher (2025) In-depth studies: pathway of green space – stress – mental health in children Kerstin Persson Waye/Natalia Vincens (shared) et al 2025 WP1 members. New insights into the conceptual framework for children’s exposome mental health, well-being and cognition (2025). WP2 Zhiyang Wang, Gabin Drouard, Aleksei Afonin, Núria Botella, Carmen Peuters, Aino-Kaisa Piironen, Alyce. M. Whipp, Boris Cheval, Libor Šulc, Marja Heinonen-Guzejev, Maria Foraster, John Gulliver, Jenny Selander, Payam Dadvand, Jordi Júlvez, Irene van Kamp, Katja M. Kanninen, Jaakko Kaprio, Equal-Life Scientific Team (2025) Associations between the midadolescent external exposome and proteomic biomarkers of mental health [under review] preprint available: https://doi.org/10.1101/2024.12.18.24319208. Afonin, A. M., Piironen, A.-K., Julvez, J., van Kamp, I., & Kanninen, K. M. (2024). Plasma proteome demonstrates sex-specific associations with mental health risks in adolescents. [pre-print, submitted to Psychiatry Research]medRxiv. https://doi.org/10.1101/2024.12.16.24319062 Katja Kanninen (Aino-Kaisa Piironen), UEF, Walnuts cohort owners, Metabolomics identifies associations of plasma markers and altered fatty acid profiles with the risk of mental health issues in adolescents WP3 Loh, K., Seitz, J., Nolden, S., Gudi-Mindermann, H., Dohmen, M., van Kamp, I., Botteldooren, D., Hornikx, M., Bolte, G., & Fels, J. (2025). Cognitive milestone at the age of four: Intentional switching of auditory selective attention in preschool children. [Manuscript submitted for publication]. Scientific Reports. M.E.Terzakis, F. Naim, C. Van hoorickx, M.Hornikx, D.Fecht., A.L. Hansell, J. Gulliver (2025) Estimation of Outdoor-to-Indoor Noise Attenuation for Night-Time Residential Noise Exposure based on Noise Indicators. Applied acoustics [under review] M.E.Terzakis, C. Van hoorickx, M.Hornikx, (2025) An outdoor-to-indoor sound propagation modelling framework for evaluating noise exposure applications. Acta Acustica [under review] Arnaud Can, Goteborg team (2025) Characterizing appropriate outdoor and indoor sound environments for children mental health Arnaud Can, Dick Botteldooren, ABCD, ALPINE (2025) on the selection on noise indicators for exposome assessment and their estimation This project has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No 874724 8 Dick Botteldooren, Timothy Van Renterghem (2025) Machine Learning surrogate model for noise exposure indicators Dick Botteldooren (2025) on the selection on indicators for exposome assessment Seitz, J., & Fels, J. (2025b). Differences between subjective and behavioral listening effort in children across age and task complexity. [Manuscript under review]. Ear & Hearing. Seitz, J., Sinarso, A., Bolte, G. & Fels, J. (2025c). Socioeconomic Status Shapes Children’s Listening Effort Under Classroom Noise. [Manuscript will be submitted 07/2025]. Journal of Environment and Behavior. Seitz, J., Westphal, V., & Fels, J. (2025d). Tentative: Subjective and behavioural listening effort across task difficulty in preschool children. [Manuscript in progress]. Trends in Hearing. Seitz, J., Berger, J., & Fels, J. (2025e). Tentative: Subjective and behavioural listening effort across task difficulty in adults. [Manuscript in progress]. Trends in Hearing. Seitz, J., Berger, J., & Fels, J. (2025f). Tentative: Comparing measures for assessing listening effort in children. [Manuscript in progress]. Journal of the Acoustical Society of America. WP4: Tönnies J, Ahrens J, Hasselder P, van Houten P, van Eerten JJ, White M, Weber M, Bolte G. Tackling transport poverty with offers for shared mobility – a qualitative analysis on a mobility hub in a deprived neighbourhood from a public health perspective. Cities & Health [revised and resubmitted] Ahrens J, White M, Jeram S, Ristovka G, Koning J, Gudi-Mindermann H, Tönnies J, Czwikla G, Weber M, Bolte G. A framework to consider equity in urban intervention planning, implementation, and evaluation. [to be submitted] Gabriele Bolte, Irene van Kamp, Hendriek Boshuizen (2025) Combining the physical and social exposome (theory paper). In preparation WP6: Hendriek Boshuizen, Irene van Kamp, Carmen Peuters, Botteldooren (2025) Characterising the exposome (method paper) Hendriek Boshuizen, Equal-Life scientific team (2025) Pooled analysis. This project has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No 874724 9 WP7: Libor Sulc, et al. (2025) on ADHD diagnosis in children (at or before age 16) and prenatal exposome (social and physical). Fan Wu (2025) on autism diagnosis in children (at or before age 16) and prenatal exposome (social and physical). Karl Lundin Remnélius (2025) ADHD/autism and the differences between these diagnoses by sex. Carmen Peuters, ……..van Kempen, E., Jordi Julvez et al. (2025) The physical and social external exposome during early life and child selective attention: a multi-cohort study. WP8/9: Sandionigi, A., Benz S. et al. (2025), Simplifying Access to Mental Health Research: The EqualLife Toolbox and Guidebook Sandionigi, A., Benz S et al. (2025), Investigation into awareness of the effects of factors that can influence children's mental health. An exposome perspective. WP10: Irene van Kamp, Equal-Life scientific team (2025) Overall outcomes Equal-Life. Irene van Kamp, Erik Lebret, Julia Hartman, Kim van Wijk (2025) Lessons learned interdisciplinary collaboration. 4 Other Publications 1. Bolte, G. (2024). Social-epidemiological perspectives on environmental health research. International EXPOHEALTH Workshop, Mainz, Germany, 30.10.2024. 2. Dohmen, M. E., Braat-Eggen, Ella, Kemperman, Astrid, & Hornikx, Maarten. (2024). A laboratory experiment exploring the effect of chronicand background noise on cognitive performance and motivation. 30th International Congress on Sound and Vibration, Amsterdam, The Netherlands. 3. Drouard, Gabin. (2024). Multi-Omic Associations of Epigenetic Age Acceleration are Heterogeneously Shaped by Genetic and Environmental Influences. Talk at WORKSHOP W3 – New developments in twin studies of Epigenetics. The Joint 7th World Congress on Twin Pregnancy and 19th Congress of the International Society of Twin Studies (ISTS), Assisi, Perugia, Italy, September 26th – 28th, 2024.