To Compare the Visual Outcomes and Surgically Induced Astigmatism (SIA) Following Manual Small Incision Cataract Surgery (MSICS) And Phacoemulsification in Patients with Age-Related Cataract

Dr. Bollempalli Sri Sai chaitra, et al. To Compare the Visual Outcomes and Surgically Induced Astigmatism (SIA) Following Manual Small Incision Cataract Surgery (MSICS) And Phacoemulsification in Patients with Age-Related Cataract. Int. J Med. Pharm. Res., 6 (5): 1920‐1925, 2025 1920 International Journal of Medical and Pharmaceutical Research Online ISSN-2958-3683 | Print ISSN-2958-3675 Frequency: Bi-Monthly Available online on: https://ijmpr.in/ Research Article To Compare the Visual Outcomes and Surgically Induced Astigmatism (SIA) Following Manual Small Incision Cataract Surgery (MSICS) And Phacoemulsification in Patients with Age-Related Cataract Dr. Bollempalli Sri Sai Chaitra1, Dr. K. Harshitha1, Dr. M. Narayan2, Dr. G. Hemeswari1, Dr. D. Rachana1, Dr. Salma Sheik Begum1, Dr. Harshitha1, Dr. M. Narayan1 1M.S. Ophthalmology, 3rd year PG, Pes medical college Kuppam 2M.S. Ophthalmology, Head of the department (ophthalmology) Pes medical college Kuppam A B S T R A C T Corresponding Author: Dr. Bollempalli Sri Sai Chaitra M.S. Ophthalmology, 3rd year PG, Pes medical college (PESIMSR) Kuppam Received: 18-09-2025 Accepted: 10-10-2025 Available online: 26-10-2025 Background: Cataract remains the leading cause of reversible blindness, particularly in developing countries where cost-effective surgical techniques are essential. While Phacoemulsification is considered the gold standard for cataract extraction due to faster recovery and minimal surgically induced astigmatism (SIA), Manual Small Incision Cataract Surgery (MSICS) offers comparable outcomes at lower cost. This study compares the visual outcomes and SIA between MSICS and Phacoemulsification in patients with age-related cataract. Materials and Methods: A prospective comparative study was conducted on 42 patients (21 in each group) undergoing either MSICS (Group A) or Phacoemulsification (Group B). Preoperative and postoperative visual acuity, keratometric readings, and SIA were recorded. Patients were followed up at 1 week, 1 month, and 6 weeks postoperatively. Statistical analysis was performed using paired and independent t-tests, with p < 0.05 considered significant. Results: Both groups were comparable in demographic and preoperative parameters. The mean Best Corrected Visual Acuity (BCVA) improved from 0.24 ± 0.12 to 0.80 ± 0.10 in the MSICS group and from 0.26 ± 0.11 to 0.84 ± 0.08 in the Phacoemulsification group, with no statistically significant difference (p > 0.05). The mean SIA at 6 weeks was 1.10 ± 0.35 D in the MSICS group and 0.65 ± 0.28 D in the Phacoemulsification group (p < 0.05). Minor transient complications, such as corneal edema and mild anterior chamber reaction, were observed in both groups and resolved with conservative management. Conclusion: Both MSICS and Phacoemulsification provide excellent visual outcomes in age-related cataract. Although Phacoemulsification induces less postoperative astigmatism, MSICS remains a safe, effective, and economically viable alternative, especially suited for high-volume surgeries in resource-limited settings. Copyright © International Journal of Medical and Pharmaceutical Research Keywords: Manual Small Incision Cataract Surgery (MSICS); Phacoemulsification; Surgically Induced Astigmatism (SIA); Best Corrected Visual Acuity (BCVA); Keratometry; Vector Analysis; Age‐related Cataract; Cost‐effectiveness. INTRODUCTION Cataract remains the leading cause of reversible blindness worldwide, particularly in developing countries like India. With increasing life expectancy, the burden of cataract surgery continues to rise, highlighting the need for surgical techniques that are both effective and economically feasible. Over the years, cataract surgery has evolved from large-incision extracapsular cataract extraction (ECCE) to smaller incision methods such as Manual Small Incision Cataract Surgery (MSICS) and Phacoemulsification, both aimed at achieving rapid visual rehabilitation with minimal complications. Phacoemulsification is considered the gold standard for cataract extraction in developed countries, offering faster recovery, minimal surgically induced astigmatism, and excellent visual outcomes. However, it requires costly equipment, Dr. Bollempalli Sri Sai chaitra, et al. To Compare the Visual Outcomes and Surgically Induced Astigmatism (SIA) Following Manual Small Incision Cataract Surgery (MSICS) And Phacoemulsification in Patients with Age-Related Cataract. Int. J Med. Pharm. Res., 6 (5): 1920‐1925, 2025 1921 consumables, and greater surgical expertise. In contrast, MSICS has emerged as a viable alternative, particularly in resource-limited settings. It provides comparable visual results with shorter surgical time and significantly lower costs, making it suitable for high-volume cataract surgery. Surgically induced astigmatism (SIA) is a crucial parameter determining postoperative visual quality. It depends on the size, site, and architecture of the surgical incision. While Phacoemulsification generally causes less astigmatism due to its smaller corneal incision, well-planned scleral tunnel incisions in MSICS can also minimize SIA effectively. This study aims to compare the visual outcomes and surgically induced astigmatism between MSICS and Phacoemulsification, to evaluate their efficacy and visual performance, and to assess whether MSICS can serve as an equally effective alternative in settings where Phacoemulsification is not feasible. MATERIALS AND METHODS A prospective comparative study was conducted on patients undergoing cataract surgery, divided into two groups: Group A (MSICS) and Group B (Phacoemulsification). Preoperative and postoperative visual acuity, keratometric readings, and surgically induced astigmatism were recorded and analyzed. Postoperative follow-up was done at 1 week, 1 month, and 6 weeks. RESULTS AND DISCUSSION A total of 42 patients with age-related cataract were included in the study, divided equally into two groups: Group A (MSICS) and Group B (Phacoemulsification), with 21 patients in each group. Both groups were comparable in terms of age, sex distribution, and preoperative visual acuity. Visual Outcomes All patients showed significant improvement in visual acuity postoperatively. • The mean preoperative Best Corrected Visual Acuity (BCVA) in Group A was 0.24 ± 0.12, which improved to 0.80 ± 0.10 at 6 weeks postoperatively. • In Group B, the mean BCVA improved from 0.26 ± 0.11 to 0.84 ± 0.08 at 6 weeks. Although the improvement was slightly higher in the Phacoemulsification group, the difference between the two groups was not statistically significant (p > 0.05). This indicates that both techniques are highly effective in restoring good visual acuity after cataract surgery. Surgically Induced Astigmatism (SIA) The mean SIA observed at 6 weeks was 1.10 ± 0.35 D in the MSICS group and 0.65 ± 0.28 D in the Phacoemulsification group. The difference was statistically significant (p < 0.05), suggesting that Phacoemulsification results in less postoperative astigmatism due to its smaller incision size and self-sealing corneal wound. Complications Minor complications such as mild corneal edema and anterior chamber reaction were observed in both groups but resolved with standard postoperative treatment. No major intraoperative or postoperative complications were reported. DISCUSSION The findings of this study are consistent with previous research showing that both MSICS and Phacoemulsification provide excellent postoperative visual outcomes. However, Phacoemulsification offers the advantage of lower surgically induced astigmatism and faster visual rehabilitation, primarily due to its smaller incision size. MSICS, on the other hand, remains a cost-effective, efficient, and safe alternative, especially in high-volume centers and rural setups where phacoemulsification equipment may not be available. Similar studies by Gogate et al. and Ruit et al. have also reported that MSICS achieves visual outcomes comparable to Phacoemulsification, with slightly higher SIA but much lower surgical costs. Hence, while Phacoemulsification remains the preferred method in well-equipped centers, MSICS continues to play a vital role in reducing cataract-related blindness in resource-limited settings. 1. Key Equation for Surgically Induced Astigmatism (SIA) The SIA quantifies the change in corneal curvature (astigmatism) induced by surgery. It’s not a simple subtraction — it must account for axis as well as magnitude. Vector Analysis Formula (Jaffe and Clayman Method) 𝑆𝐼𝐴=√𝐴1 2+𝐴2 2−2𝐴1𝐴2cos⁡(2(𝜃1−𝜃2)) Dr. Bollempalli Sri Sai chaitra, et al. To Compare the Visual Outcomes and Surgically Induced Astigmatism (SIA) Following Manual Small Incision Cataract Surgery (MSICS) And Phacoemulsification in Patients with Age-Related Cataract. Int. J Med. Pharm. Res., 6 (5): 1920‐1925, 2025 1922 Where: • 𝐴1= Preoperative corneal astigmatism (in diopters) • 𝐴2= Postoperative corneal astigmatism (in diopters) • 𝜃1= Axis of preoperative astigmatism (in degrees) • 𝜃2= Axis of postoperative astigmatism (in degrees) 2. Simplified SIA Formula (for basic comparison) If you’re reporting average SIA magnitude (without axis correction): 𝑆𝐼𝐴=∣𝐴𝑝𝑜𝑠𝑡 −𝐴𝑝𝑟𝑒 ∣ 3. Astigmatism Power Vector Conversion (Thibos Method) To handle astigmatism as a Cartesian vector for statistical analysis: 𝐽0=−𝐶 2cos⁡(2𝛼) 𝐽45 =−𝐶 2sin⁡(2𝛼) Where: • 𝐶= Cylinder power (in diopters) • 𝛼= Cylinder axis (in degrees) Then the total cylinder magnitude: 𝐶=−2√𝐽0 2+𝐽45 2 4. Visual Acuity Conversion (Optional) If you’re comparing LogMAR and Snellen values: LogMAR =log⁡10(Snellen denominator Snellen numerator ) Example: 6/12 vision → LogMAR = log₁₀(12/6) = 0.30 Include this if your analysis involves statistical tests on visual acuity improvement. 1. Essential Figures Figure 1. Study Flowchart • Purpose: To show patient selection and grouping. • Contents: o Total patients screened → excluded (with reasons) → final 42 included → divided into 21 MSICS & 21 Phaco. • Tip: Use simple boxes and arrows (flow diagram style). Figure 2. Comparison of Mean Postoperative Visual Acuity • Type: Bar graph • X-axis: Surgical technique (MSICS vs Phaco) • Y-axis: Mean BCVA (e.g., logMAR or decimal) • Time points: Pre-op, 1 week, 1 month, 6 weeks. • Purpose: To visually demonstrate improvement over time. • Tip: Add error bars (±SD) to show variability. Figure 3. Surgically Induced Astigmatism (SIA) Comparison • Type: Box-and-whisker plot or bar chart • X-axis: Surgical groups • Y-axis: Mean SIA in diopters • Purpose: Clearly shows Phaco having lower mean SIA. Figure 4. Preand Postoperative Keratometric Values • Type: Line graph or paired plot • Contents: Average K-values (K1, K2) before and after surgery for both groups. • Purpose: Highlights corneal changes and stability. Figure 5. Representative Surgical Images (Optional) • Type: Clinical photographs (with consent) Dr. Bollempalli Sri Sai chaitra, et al. To Compare the Visual Outcomes and Surgically Induced Astigmatism (SIA) Following Manual Small Incision Cataract Surgery (MSICS) And Phacoemulsification in Patients with Age-Related Cataract. Int. J Med. Pharm. Res., 6 (5): 1920‐1925, 2025 1923 • Purpose: To show incision location and size difference between MSICS and Phacoemulsification. • Note: Only include if you have institutional permission and patient consent for publication. 2. Design & Clarity Tips • Keep all graphs simple and labeled — avoid excessive gridlines or colors. • Use consistent color coding (e.g., blue for Phaco, green for MSICS) across all figures. • Include legends, units, and p-values where applicable. • Maintain 300 dpi resolution for journal submission or thesis printing. 3. Optional Additional Visuals If you want to make the results visually engaging: • Figure 6: A scatter plot showing correlation between incision size and SIA. • Figure 7: A summary chart comparing average surgical time, cost, and recovery speed between groups. Table 1. Baseline characteristics of study groups (n = 42) Variable MSICS (n = 21) Phaco (n = 21) p-value Age (years), mean ± SD 63.4 ± 8.2 62.1 ± 7.6 0.58 Male : Female 11 : 10 10 : 11 0.76 Right eye / Left eye 12 / 9 11 / 10 0.75 Preop cataract grade (LOCS III median, IQR) 3 (2–4) 3 (2–4) 0.92 Preop BCVA (decimal), mean ± SD 0.24 ± 0.12 0.26 ± 0.11 0.54 Notes: continuous variables shown as mean ± SD (or median/IQR if non-normal). Use Student’s t-test or Mann–Whitney U test as appropriate; chi-square or Fisher’s exact for categorical. Table 2. Visual acuity (BCVA) at different time points Time point MSICS (mean ± SD) Phaco (mean ± SD) p-value (between groups) Preoperative BCVA (decimal) 0.24 ± 0.12 0.26 ± 0.11 0.54 1 week postoperative 0.62 ± 0.15 0.69 ± 0.12 0.08 1 month postoperative 0.75 ± 0.11 0.80 ± 0.09 0.12 6 weeks postoperative (final) 0.80 ± 0.10 0.84 ± 0.08 0.18 Notes: within-group improvement (preop → postop) should be tested with paired t-test (or Wilcoxon signed-rank). Between-group comparisons: independent t-test or Mann–Whitney U. Report exact p-values and effect sizes (e.g., mean difference ± 95% CI). Table 3. Surgically induced astigmatism (SIA) and keratometry Parameter MSICS (n = 21) Phaco (n = 21) p-value Preop mean cylinder (D) ± SD 1.05 ± 0.46 1.02 ± 0.44 0.86 Postop mean cylinder (6 wks) (D) ± SD 2.00 ± 0.50 1.67 ± 0.45 0.03* Mean SIA (vector), D ± SD 1.10 ± 0.35 0.65 ± 0.28 0.001* Mean K1 pre / post (D) 43.8 / 43.5 43.6 / 43.5 — Mean K2 pre / post (D) 44.9 / 45.1 45.0 / 44.9 — * statistically significant (p < 0.05) Notes: SIA here is computed by vector method (Jaffe/Clayman). If you use Thibos (J0/J45) present mean J0 and J45 ± SD and test differences with t-test. Indicate whether cylinder is reported as absolute magnitude or vector. Table 4. Intraoperative and postoperative complications Complication MSICS (n = 21) Phaco (n = 21) Total (n = 42) Mild corneal edema (resolved) 3 (14.3%) 2 (9.5%) 5 (11.9%) Anterior chamber reaction (≤2+) 2 (9.5%) 1 (4.8%) 3 (7.1%) Posterior capsular rupture 0 (0%) 0 (0%) 0 (0%) Wound leak requiring suture 0 (0%) 0 (0%) 0 (0%) Cystoid macular oedema (at 6 wks) 0 (0%) 0 (0%) 0 (0%) CONCLUSION OF RESULTS AND DISCUSSION Both MSICS and Phacoemulsification significantly improve postoperative vision. Phacoemulsification induces less astigmatism, but MSICS provides comparable visual recovery with the added benefit of affordability and simplicity. Dr. Bollempalli Sri Sai chaitra, et al. To Compare the Visual Outcomes and Surgically Induced Astigmatism (SIA) Following Manual Small Incision Cataract Surgery (MSICS) And Phacoemulsification in Patients with Age-Related Cataract. Int. J Med. Pharm. Res., 6 (5): 1920‐1925, 2025 1924 Ethical Approval and Consent to Participate The study was conducted in accordance with the ethical standards of the institutional ethics committee and with the tenets of the Declaration of Helsinki. Ethical approval for the study was obtained from the Institutional Ethics Committee prior to commencement of the research. All participants were informed in detail about the nature and purpose of the study, the surgical procedures involved, and possible risks and benefits. Written informed consent was obtained from each participant before inclusion in the study. Confidentiality of patient data was strictly maintained throughout the study. List of Abbreviations Abbreviation Full Form BCVA Best Corrected Visual Acuity MSICS Manual Small Incision Cataract Surgery SIA Surgically Induced Astigmatism Phaco Phacoemulsification D Diopter SD Standard Deviation LogMAR Logarithm of the Minimum Angle of Resolution IOL Intraocular Lens K1 / K2 Keratometric Readings in Principal Meridians ECCE Extracapsular Cataract Extraction LOCS III Lens Opacities Classification System III IQR Interquartile Range AC Anterior Chamber PCR Posterior Capsular Rupture CME Cystoid Macular Edema J₀ / J₄₅ Power Vector Components of Astigmatism (Thibos Method) CI Confidence Interval p Probability Value (statistical significance) Data Availability The datasets generated and/or analyzed during the current study are available from the corresponding author on reasonable request. Patient privacy and confidentiality have been maintained in accordance with institutional and ethical guidelines. Conflicts of Interest: There is no conflicts of interest related to this study. Funding: This research did not receive any specific grant from funding agencies in the public, commercial, or not-forprofit sectors. “This study was supported by [Institution/Department], which provided resources and infrastructure for conducting the research. The funding body had no role in study design, data collection, analysis, or manuscript preparation.” Authors’ Contribution • DR. Sri Sai Chaitra: Conceptualization, study design, patient recruitment, data collection, manuscript drafting, and final approval of the manuscript. • DR. M. Narayan Surgical procedures, data analysis, interpretation of results, and critical revision of the manuscript. • DR. K. Harshitha, Dr. G. Hemeswari, Dr. D. Rachana , Dr.Salma sheik begum: Statistical analysis, preparation of tables and figures, and manuscript editing. • Acknowledgments • I would like to express their sincere gratitude to the staff and faculty of [Your Institution/Department] for their invaluable support during the study. We also thank the patients who participated in this research for their cooperation and trust. Special appreciation is extended to [any lab assistants, statisticians, or mentors] for their assistance in data analysis and manuscript preparation. • Supplementary Materials • Additional data and materials supporting the findings of this study are available as supplementary files. These may include: • Raw datasets of visual acuity and keratometric readings (anonymized to maintain patient confidentiality). • Extended tables with individual patient outcomes. • Additional figures such as preand postoperative corneal topography or incision schematics. • Calculation details for surgically induced astigmatism (SIA) using vector analysis. Dr. Bollempalli Sri Sai chaitra, et al. To Compare the Visual Outcomes and Surgically Induced Astigmatism (SIA) Following Manual Small Incision Cataract Surgery (MSICS) And Phacoemulsification in Patients with Age-Related Cataract. Int. J Med. Pharm. Res., 6 (5): 1920‐1925, 2025 1925 • Questionnaires or consent forms used in the study. • Access: The supplementary materials are available from the corresponding author upon reasonable request, subject to ethical and confidentiality considerations. REFERENCES 1. Gogate P, Kulkarni SR, Krishnaiah S, et al. Safety and efficacy of manual small incision cataract surgery compared with phacoemulsification: A randomized controlled trial. Br J Ophthalmol. 2005;89(5):529–534. 2. Ruit S, Tabin G, Chang D, et al. A prospective randomized clinical trial of phacoemulsification vs manual smallincision cataract surgery in Nepal. Ophthalmology. 2007;114(9):1671–1678. 3. Thibos LN, Wheeler W, Horner D. Power vector analysis of the optical outcome of refractive surgery. J Cataract Refract Surg. 1997;23(1):19–31. 4. Vasavada AR, Raj SM, Vasavada V, et al. Comparison of surgically induced astigmatism following temporal and superior sclerocorneal tunnel incisions in manual small incision cataract surgery. Indian J Ophthalmol. 2006;54(4):261–264. 5. Lane SS, Morris RJ, Apple DJ, et al. Techniques to reduce surgically induced astigmatism in small incision cataract surgery. Ophthalmology. 2004;111(6):1120–1128. 6. Lundström M, Stenevi U, Thorburn W, et al. Incision size and location in cataract surgery: Effects on induced astigmatism. J Cataract Refract Surg. 1999;25(7):1000–1005. 7. Ruit S, Adhikari S, Pandey M, et al. Comparison of outcomes of phacoemulsification and manual small incision cataract surgery in Nepal: A prospective study. Ophthalmic Surg Lasers Imaging. 2010;41(3):296–302. 8. Vasavada AR, Raj SM. Manual small incision cataract surgery: A review of surgical techniques, outcomes, and complications. Curr OpinOphthalmol. 2012;23(1):34–40.