NUCATS snapshot: service, science, & sustainability

NUCATS snapshot: service, science, & sustainability 2025 CTSA Program Fall Annual Meeting Kristi Holmes, PhD Northwestern University [email protected] October 22, 2025 Leading the way to better careLeading the way to better care Northwestern University Clinical and Translational Sciences Institute Luke Rasmussen Yuan Luo Dan Schneider Juan Espinoza. Mohammad Hosseini Leah Welty Theresa Walunas Matt Carson Abby Cosentino-Boehm Kelly Michelson Matt Baumann Eva Winckler First, a word of thanks… core team With tremendous support for D3 from MPIs Rich D’Aquila, Sara Becker, and Clyde Yancy; Executive Director, Niki Woitowich; Program Administrator, Tony Preston; and Director of Marketing & Communications, Roger Anderson 2 Leading the way to better careLeading the way to better care Northwestern University Clinical and Translational Sciences Institute Considering the service, science, & sustainability through the lens of community and capacity building 3 Capacity Empowers teams, institutions, and communities to deliver impactful and sustainable research. Community of Practice (COP) Drive translational science by fostering shared learning, trust, and interdisciplinary innovation. Leading the way to better careLeading the way to better care Northwestern University Clinical and Translational Sciences Institute Community Building Capacity Building Service ▪ Enhances knowledge sharing and support across the different translational science personas ▪Promotes inclusive engagement and ability to respond to real-world health challenges ▪ Training programs support broad engagement with data/tooling ▪ Service delivery is supported through infrastructure and policy alignment Science ▪ Fosters interdisciplinary collaboration, enabling cocreation and rapid iteration ▪ Supports innovative practices and expertise ▪ Supports assessment and understanding ▪ Fosters transdisciplinary skills and team science competencies ▪ Nurture innovative and high-performing teams Sustainability ▪ Resilient networks persist beyond individual projects ▪ Institutionalizes collaborative behaviors and cultural norms to support collaboration and long-term impact ▪ Capacity building ensures long-term institutional readiness and resilience ▪ Supports the development of fair and FAIR translational ecosystems Considering service, science, & sustainability through the lens of community and capacity building 4 CapacityCOPs ▪James-McAlpine J, et al. Exploring the evidence base for Communities of Practice in health research and translation: a scoping review. Health Res Policy Syst. 2023 Jun 19;21(1):55. doi: 10.1186/s12961-023-01000-x. PMID: 37337214; PMCID: PMC10278351. ▪Sperling J, et al. The translational science promotion and research capacity (T-SPARC) framework: Developing institutional capacity for translational science. J Clin Transl Sci. 2025 Jul 7;9(1):e157. doi: 10.1017/cts.2025.10056. PMID: 40895446; PMCID: PMC12392354. ▪Baumann AA, et al. A mapping review and critique of the literature on translation, dissemination, and implementation capacity building initiatives for different audiences. Implement Sci Commun. 2025 Apr 3;6(1):34. doi: 10.1186/s43058-025-00717-w. Erratum in: Implement Sci Commun. 2025 Apr 25;6(1):49. doi: 10.1186/s43058-025-00740-x. PMID: 40181484; PMCID: PMC11970029. ▪Sweeney WA, et al. Developing a Translational Team Training Program using the Wisconsin Interventions in Team Science Framework. J Clin Transl Sci. 2023 Oct 19;7(1):e233. doi: 10.1017/cts.2023.649. PMID: 38028334; PMCID: PMC10643908. ▪Gonzales S, et al. Clinical and Translational Science Personas: Expansion and use cases. J Clin Transl Sci. 2023 Jun 8;7(1):e147. doi: 10.1017/cts.2023.572. PMID: 37456266; PMCID: PMC10346007. Leading the way to better careLeading the way to better care Northwestern University Clinical and Translational Sciences Institute Community Building Capacity Building Service ▪ Informatics & Data Science Collaborative: seminars, networking, shared learning ▪ Galter Library DataLab: outreach, office hours, department engagement, services, training ▪ Research Integrity Initiative: ethics lectures and consultations ▪ Leaf self-service query tool: secure, scalable access ▪ Infrastructure for data harmonization ▪ GenAI for consent summaries: improving participant understanding; plain language summaries ▪Biostatistics Collaboration Center research services, support, and training (Welty) Science ▪ BIDS EC: cross-hub collaboration and dissemination ▪ Open source engagement: InvenioRDM, RSE ▪ Make Data Count: data metrics standard; data evaluation, resources, maturity model in collaboration with HELIOS Open ▪ Evaluation infrastructure ▪ Adaptive randomization in REDCap: innovative trial design* ▪ Software and data dissemination framework: tool sharing and reuse; tracking and impact ▪ DataLab support and training: FAIR, reproducibility, and open science; maDMP Sustainability ▪ CTSA-wide collaboration: best practices and engagement ▪ Open science networks: long-term community infrastructure, standards, best practices ▪ Quarterly validation cycles ▪ NIH Public Access Policy support ▪ Institutional investment in scalable tools, training ▪ GREI coopetition model 5 Considering NUCATS service, science, & sustainability CapacityCOPs Schauer JM, Broxton MO, Rasmussen LV, Swann G, Newcomb ME, Ciolino JD. Workflows to automate covariate-adaptive randomization in REDCap via data entry triggers. JAMIA Open. 2025 Oct 1;8(5):ooaf110. doi: 10.1093/jamiaopen/ooaf110. PMID: 41041624; PMCID: PMC12486239. Leading the way to better careLeading the way to better care Northwestern University Clinical and Translational Sciences Institute Sustainability | Example: GREI Coopetition GREI Coopetition: Supporting the NIH Strategic Plan for Data Science 6 Goal: Improve capabilities to sustain the NIH policy for data management and sharing Objective: Strengthen NIH data repository and knowledgebase ecosystem Structure: a model of “Coopetition” where we collaborate on shared goals and compete on unique features Access all GREI resources linked via the NIH ODSS GREI landing page bit.ly/ODSSGREI Leading the way to better careLeading the way to better care Northwestern University Clinical and Translational Sciences Institute Sustainability | Example: GREI Coopetition GREI Coopetition in Action. Collaborate on shared goals and compete on unique features 7 https://bit.ly/GREIcoopetition PREPRINT: Coopetition as a Model to Advance a FAIR Data Ecosystem Governance Framework ▪Enhanced efficiencies ▪Streamlined decision-making and workflows ▪Shared leadership ▪Shared deliverables enhance functionality and services Strategic Partnerships ▪Productive collabs with: DataCite, ROR, Make Data Count, USRN, FASEB, The Carpentries, NLM Dataset Catalog, and others ▪Accelerate innovation through knowledge sharing ▪Supports emerging opportunities Cross-Repository Consistency ▪Implemented shared metadata standards (e.g., DataCite, MeSH) ▪Aligned metrics using Make Data Count best practices ▪Enable crossrepository linking and discovery User-Focused Approach ▪Incorporate community feedback loops ▪Collaborate on GREI events and training resources ▪Harmonize metadata across repositories ▪Increased transparency and accountability Thank you! Kristi Holmes, PhD Northwestern University [email protected]