Sensori bioriassorbibili nel corpo: nuove frontiere della medicina

Sensori bioriassorbibili nel corpo: nuove frontiere della medicina Giuseppe Barillaro Dip. Ingegneria dell’Informazione Università di Pisa [email protected] Google image Diagnostica point-of-care Courtesy of: Medtronics, BostonScientific, MEDEL Dispositivi impiantabili tradizionali Photo credit: Beckman Institute, University of Illinois and Tufts University Credits to: Prof. J. Rogers’s Group Sensori bioriassorbibili, cosa sono? J.-K. Chang, et al. , Proc. Natl. Acad. Sci. USA 2017, 114, E5522. La Mattina et al., Advanced Science (2020). A che punto siamo? D1.2 Project Public Launch WP1 Project Management, Dissemination, Exploitation, Communication This project is funded by the European Union Horizon Europe programme under grant agreement No 101046946 This project has received funding from the European Union’s Horizon 2020 research and innovation programm e under grant agreem ent No 952071 D1.2 - Project Quality Handbook WP1 - Project coordination and technical management Partner: PNO Authors: Carolina Salas, Antonio M . Ortiz, Jeanett Bolther Version: v. final Date: 31.08.2020 www.resorb-project.eu sensori chimici impianto resorb batterie and LEDs 14 220 h (Figure 3g-i). The PL intensity decrease can be ascribed to the degradation, chemical and/or 1 mechanical, of the fluorescent polymer multilayer, given that the silica scaffold dissolved in about 2 50 hours. The polymer brush architecture of the fluorescent multilayer after dissolution of the silica 3 scaffold might impact significantly on its degradation (Figure S14). Remarkably, full sensor 4 degradation occurred on the same timescale as the sensor operation, that is in about 100 hours. By 5 best fitting the PL reduction trend with a linear model, degradation rates of about -0.9 and -0.8 % h6 1 were consistently achieved for pH sensors on native silicon in a flow cell and on PLGA foil under 7 artificial skin, respectively. The polymer multilayer degradation was further confirmed by both 8 optical/fluorescence microscopy. No macroscopic polymer residues or residual photoluminescence 9 were found in the solution collected at the output of the flow cell or in the skin around the sensor 10 location at the end of the experiment, indicating a full degradation of the polymer and, in turn, of 11 the sensor occurred, apart from the PLGA foil that is known to degrade at a slower rate2. 12 13 14 220 h (Figure 3g-i). The PL intensity decrease can be ascribed to the degradation, chemical and/or 1 mechanical, of the fluorescent polymer multilayer, given that the silica scaffold dissolved in about 2 50 hours. The polymer brush architecture of the fluorescent multilayer after dissolution of the silica 3 scaffold might impact significantly on its degradation (Figure S14). Remarkably, full sensor 4 degradation occurred on the same timescale as the sensor operation, that is in about 100 hours. By 5 best fitting the PL reduction trend with a linear model, degradation rates of about -0.9 and -0.8 % h6 1 were consistently achieved for pH sensors on native silicon in a flow cell and on PLGA foil under 7 artificial skin, respectively. The polymer multilayer degradation was further confirmed by both 8 optical/fluorescence microscopy. No macroscopic polymer residues or residual photoluminescence 9 were found in the solution collected at the output of the flow cell or in the skin around the sensor 10 location at the end of the experiment, indicating a full degradation of the polymer and, in turn, of 11 the sensor occurred, apart from the PLGA foil that is known to degrade at a slower rate2. 12 13 Sensore impiantabile e bioriassorbibile di pH M. Corsi, A. Paghi, et al., Adv Sci (2022) 3 4 5 6 7 8 10k 20k 30k 40k 50k as prepared bending@r=2.5 cm bending@r=2 cm bending@r=1 cm twisting PL intensity (counts) pH …è flessibile e robusto as prepared bending@ r=2.5 cm bending@ r=2 cm bending@ r=1 cm twisting 0 2k 4k 6k 8k |Sensitivity| (counts/pH) 100 cycles 100 cycles A. Paghi, M. Corsi, et al., Advanced Materials Technologies (2023) 015 30 45 60 75 7 6 5 4 3 Measured pH Time (h) Real pH 3 4 5 6 7 8 2 3 4 5 6 7 8 Measured pH Real pH Slope: 1.01 A. Paghi, M. Corsi, et al., Advanced Materials Technologies (2023) ..e può essere letto con un circuito indossabile in wifi