First report on the meta-analyses of the association with lifestyle and the moderating role of socioeconomic context, mental health and genetic factors.

Deliverable 4.5 First report on the meta-analyses of the association with lifestyle and the moderating role of socioeconomic context, mental health and genetic factors. Author’s name: Susanne Bruins, Dorret I. Boomsma, René Pool Date: 30.04.2025 2 Deliverable D4.5 Document ID D4.5 Due date 30/04/2025 Submission date 30/ / Dissemination level Confidential Work Package Keywords Meta-analysis, meta-regression, harmonized data, BMI, BMI ch weight, weight change, lifestyle 3 Deliverable D4.5 4 Deliverable D4.5 5 Deliverable D4.5 6 Deliverable D4.5 7 Deliverable D4.5 8 Deliverable D4.5 9 Deliverable D4.5 16 Deliverable D4.5 guidelines baseline last baseline last ● baseline last ● baseline last ● baseline last baseline last baseline last ● sex bh education_group ● (z_)bmi x age; ● (z_)bmi x b_year; ● (z_)bmi x sex; ● bw x age; ● bw x b_year; ● bw x sex; ● bh x age; ● bh x b_year; ● bh x sex. 17 Deliverable D4.5 1. bmi ~ age + sex + cohort-specific covariates; 2. bmi ~ age + b_year + sex + cohort-specific covariates; 3. bh ~ age + sex + cohort-specific covariates; 4. bh ~ age + b_year + sex + cohort-specific covariates; 5. bw ~ age + sex + cohort-specific covariates; 6. bw ~ age + b_year + sex + cohort-specific covariates; 7. z_bmi ~ age + sex + cohort-specific covariates; 8. z_bmi ~ age + b_year + sex + cohort-specific covariates. β FID β β 18 Deliverable D4.5 FID metafor 19 Deliverable D4.5 baseline 20 Deliverable D4.5 • age b_year • age b_year 21 Deliverable D4.5 • age b_year • age b_year age age sex sex b_year b_year 22 Deliverable D4.5 age age sex sex b_year b_year age age sex sex b_year b_year 23 Deliverable D4.5 age age sex sex b_year b_year 24 Deliverable D4.5 • βage • βsex • • βage • βsex • • βage • βsex • • βage • βsex • 25 Deliverable D4.5 • βage age age βsex sex sex βb_year b_year b_year • • • • • • 32 Deliverable D4.5 -0.012 0.005 .031 -23.539 13.769 21.863 .001 -0.014 0.01 .142 -23.068 13.534 31.306 -0.027 0.019 .165 -11.404 7.702 20.367 -0.027 0.019 .157 -11.53 7.765 19.312 -0.047 0.004 -13.299 8.650 1.015 .908 -0.055 0.018 .002 -4.292 4.146 0.957 .812 -0.043 0.004 -10.716 7.358 0.001 .976 -0.046 0.004 -10.713 7.356 0.010 .920 11 bmi_change 0.046 0.021 .026 -8.357 6.179 4.998 .082 22 bmi_change 0.046 0.021 .025 -8.411 6.206 4.897 .086 33 Deliverable D4.5 55 bw_change 0.068 0.008 -6.119 5.059 0.821 .365 66 bw_change 0.069 0.008 -6.146 5.073 0.791 .374 bmi_change 0.026 0.024 .288 -17.427 10.713 42.495 bmi_change 0.025 0.024 .294 -17.4 10.700 42.504 bmi_change -0.002 0 -0.604 2.302 50.040 bmi_change -0.002 0.001 .009 -27.737 15.868 9.477 .009 bw_change 0.059 0.073 .416 -0.736 2.368 22.635 bw_change 0.059 0.074 .424 -0.609 2.305 22.806 bw_change -0.004 0.001 -23.904 13.952 6.977 .031 bw_change -0.004 0.001 .003 -22.953 13.477 10.786 .005 27 MET_week_last bmi_change -0.002 0.001 .022 -57.647 30.823 106.998 38 MET_week_last bmi_change -0.002 0.001 .028 -57.480 30.740 108.952 34 Deliverable D4.5 35 Deliverable D4.5 • • • • • • 36 Deliverable D4.5