MOOC on the basis of In the Heart of Medical Radioactivity

Deliverable D6.5 MOOC on the basis of In the Heart of Medical Radioactivity This project has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No 101008571 (PRISMAP). This document reflects only the view of the author(s). The Agency is not responsible for any use that may be made of the information it contains. Deliverable D6.5 ii Project Acronym PRISMAP Project Title The European medical isotope programme: Production of high purity isotopes by mass separation Grant Agreement No. 101008571 Topic INFRAIA-02-2020: Integrating Activities for Starting Communities Project start date 01 May 2021 Nature Report Dissemination level Public Due date M16 – revised to M28 Date of delivery M30 Lead partner ARRONAX Contributing partners KULeuven, SCIPROM Authors Ferid Haddad (ARRONAX), Anne Le Pennec (ARRONAX), Thomas Elias Cocolios (KULeuven), Damien Aubert (SPIN, Nantes Université), Barthélémy Ramée (Nantes Université), Filippo Gander (SCIPROM) Reviewers Michèle Coeck (SCK CEN), António Rocha Paulo (IST-ID), Kirsten Leufgen (SCIPROM) Point of Contact Ferid Haddad Institution ARRONAX E-mail [email protected] Phone +33 2 28 21 21 21 © PRISMAP 2021. This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. Deliverable D6.5 iii Revision History Version Date Author Comment 0.1 17.10.2022 Anne Le Pennec Ferid Haddad First draft on initial plans 0.2 03.08.2023 Thomas Elias Cocolios Second draft based on the pilot project 03.08.2023 Kirsten Leufgen Initial review 0.3 04.08.2023 Thomas Cocolios Merging content between v0.1 and v0.2 0.3 24.08.2023 Anne Le Pennec Corrections 0.5 31.08.2023 Anne Le Pennec Adding data about the pilot phase 0.6 31.08.2023 Thomas Elias Cocolios Review, fixed automatic figure references 0.7 01.10.2023 Anne Le Pennec, Ferid Haddad, Filippo Gander Version completed after launch of MOOC on 28 Sep 2023 0.8 02.10.2023 Kirsten Leufgen Final review 0.9 26.10.2023 Thierry Stora Review by the coordinator 1.0 27.10.2023 Kirsten Leufgen Final version, approved by the coordinator Deliverable D6.5 iv Contents Abbreviations, Participant short names v Abbreviations v Participant short names v List of Figures vi Summary 1 1. Objectives 2 1.1 Target audience 2 1.2 Monitoring indicators 2 2. Technical challenges and solutions 2 2.1 Background: In the Heart of Medical Radioactivity 2 2.2 ExtraDoc tool 3 2.3 Access 5 2.3.1 Via the PRISMAP website 5 2.3.2 User account creation 6 2.4 Certificate of completion 6 3. Content of the MOOC 6 3.1 Existing material 6 3.1.1 Introduction 7 3.1.2 What is radioactivity? 7 3.1.3 Production of radioactive isotopes 7 3.1.4 Radiopharmaceuticals: definition and mode of action 7 3.1.5 Medical applications 7 3.1.6 Radioprotection 7 3.2 Additional material 8 3.2.1 Production 9 3.3 FAQ 9 3.4 Evaluation 9 4. Timeline from the production to the deployment 9 4.1 Development phase 9 4.2 Pilot project 10 4.3 Deployment 10 5. Conclusions 10 Deliverable D6.5 v Abbreviations, Participant short names ... Abbreviations … ANR Agence Nationale de la Recherche FAQ Frequently Asked Questions FDG fluorodeoxyglucose FUN France Université Numérique IAEA International Atomic Energy Agency ISI-NucMed Interdisciplinary School in Nuclear Medicine MOOC Massive Open Online Course PET Positron Emission Tomography SPIN Service de Production et d'Innovation Numérique Participant short names CERN European organization for nuclear research NPL National Physical Laboratory PSI Paul Scherrer Institut CEA Commissariat à l’énergie atomique et aux énergies alternatives IST-ID Associação do Instituto Superior Técnico para a IST-ID Investigação e Desenvolvimento DTU Danmarks Tekniske Universitet CHUV Centre hospitalier universitaire vaudois GANIL Grand Accélérateur National d’Ions Lourds SCK CEN Studiecentrum voor Kernenergie / Centre d'étude de l'énergie nucléaire ARRONAX Groupement d’intérêt public ARRONAX ESS European spallation source ERIC TUM Klinikum rechts der Isar der technischen Universität München KULeuven Katholieke Universiteit Leuven MedAustron Entwicklungsund Betriebsgesellschaft MedAustron GmbH SCIPROM SCIPROM Sàrl MUI Medizinische Universität Innsbruck ILL Institut Max von Laue - Paul Langevin JRC JRC -Joint Research CentreEuropean Commission NCBJ Narodowe Centrum Badań Jądrowych GSI GSI Helmholtzzentrum fr Schwerionenforschung GmbH Deliverable D6.5 vi LU Latvijas Universitāte INFN Istituto Nazionale di Fisica Nucleare UiO Universitetet i Oslo List of Figures ...... // Keep this line in place. It is need to fix a Word-bug in the TOC. ... - Figure 1: Logo of the original MOOC At the Heart of Medical Radioactivity. 2 Figure 2: Overview of the PRISMAP MOOC content on the ExtraDoc platform. 3 Figure 3: Example of material content on the ExtraDoc platform. 4 Figure 4: (Left) Extract of a slideshow. (Right) Transcript of a video 5 Figure 5: (Left) Access to the MOOC from the PRISMAP website, under Educational Resources. (Right) Login page for the MOOC on ExtraDoc. 5 Figure 6: (Left) ExtraDoc account creation page. (Right) Registration page for the MOOC. 6 Figure 7: Badges that may be earned over the PRISMAP MOOC. 6 Figure 8: Sample of the video material composing the MOOC At the Heart of Medical Radioactivity designed by Nantes Université, and reused in the new MOOC At the heart of European medical radioactivity. 8 Figure 9: (Left) Example of a quiz at the end of an episode. (Right) Introduction to a quiz at the end of a thematic section. 9 Figure 10: New version of the animated logo Clyde for the promotion of the MOOC. 10 Summary ... // Keep this line in place. It is need to fix a Word-bug in the TOC. This document presents the Massive Open Online Course (MOOC) entitled At the heart of European medical radioactivity proposed by PRISMAP to PhD students, young researchers and to professionals working in nuclear medicine and related disciplines. This pedagogical tool is an extension of the MOOC At the heart of medical radioactivity produced by Nantes Université (France) and presents in different steps the interest of medical radioactivity, from the conception of a radiopharmaceutical drug to its use in patients. The MOOC At the heart of European medical radioactivity will be hosted on the ExtraDoc tool of Nantes Université, with an access link in the Educational Resources page of the PRISMAP website. It was published on the ExtraDoc platform and linked to the PRISMAP website on 27 Sep 2023. Participants will have access to resources, mainly videos and quiz. If a quiz is successful, the participant will be granted an “Open Badge” that demonstrates that they have followed and validated that section of the MOOC. Additional educational content will be generated during the various thematic schools organized or supported by PRISMAP throughout the project, allowing state-of-the-art aspects to be presented as highlights. The MOOC will therefore continue to evolve beyond the initial deployment phase. This MOOC is complementary to other educational materials provided by PRISMAP on its website, such as the video on the production of radionuclides via mass separation, produced by KU Leuven, and the video on translational research with emerging radionuclides, produced by SCK CEN. Deliverable D6.5 2 1. Objectives 1.1 Target audience The MOOC At the heart of European medical radioactivity is intended for PhD students and young researchers in nuclear medicine and for professionals working in related disciplines across Europe. It provides participants with a common knowledge base essential for a proper understanding of the concepts, activities and challenges of nuclear medicine, a multidisciplinary field based on physics, chemistry, biology, pharmacy, digital sciences, etc. It will be strongly suggested to people wishing to participate in a PRISMAP thematic school to have previously followed the MOOC. The broad nature of the content may make it relevant to users beyond Europe as well. This possibility is being considered together with the IAEA, in the framework of their programme to train nuclear medicine specialists in developing countries. 1.2 Monitoring indicators  Evolution of the number of registered participants  Evolution of the number of certified participants  Evolution of the number of questions received from participants 2. Technical challenges and solutions 2.1 Background: In the Heart of Medical Radioactivity Under the hospices of France Université Numérique (FUN), an online platform hosted at the French national level, a Massive Open Online Course (MOOC) with title In the Heart of Medical Radioactivity had been developed in France by Nantes Université in partnership with LabEx IRON and Agence Nationale de la Recherche (ANR) (see Figure 1). This MOOC, coordinated by Caroline Bodet-Milin and Mickaël Bourgeois, and piloted by Marie-Hélène Gaugler and the Service de Production et d'Innovation Numérique (SPIN) of Nantes Université, was launched in 2019, one year after the French version. It presents in different sections the interest of medical radioactivity, from the design of a radiopharmaceutical drug to its use in the patient. This MOOC was open on the FUN online course platform from February 25 to May 5, 2019. A total of 291 students have attended this MOOC. However, it has since been discontinued and is no longer running. The original ambition to review this MOOC and expand on it was thus no longer possible. After some negotiations, most of the material from the original MOOC could be reused to populate an entirely new MOOC, but additional material had to be produced to replace part of the content, as well as to complement the MOOC with information of relevance within PRISMAP. The author, institution, and year of creation of every content will be clearly indicated in the caption of each video. Figure 1: Logo of the original MOOC At the Heart of Medical Radioactivity. Deliverable D6.5 3 For the production of new material, synergies with other activities supported by the PRISMAP Training Office were explored, such as the schools organised by PRISMAP in SCK CEN and DTU, or the Interdisciplinary School in Nuclear Medicine (ISI NucMed) organised by ARRONAX and Nantes Université. One of the many issues faced by this change of organisation, was that the MOOC could no longer be hosted by FUN. Different options were considered, until finally the ExtraDoc platform provided by the Nantes Université was selected. 2.2 ExtraDoc tool ExtraDoc is an online Moodle course facility proposed and hosted by Nantes Université. It contains course spaces hosting training content. Various layout options are available to provide an interface for access to content that is as ergonomic and as adapted as possible to the target audience, see Figure 2. Figure 2: Overview of the PRISMAP MOOC content on the ExtraDoc platform. Deliverable D6.5 10  Integrating the PRISMAP visual identity into the MOOC The PRISMAP visual identity was introduced into the material using Clyde, the animated logo for PRISMAP. A new version of Clyde was specifically designed by SCIPROM to promote the MOOC, see Figure 10. 4.2 Pilot project xx In April 2023, a pilot project was launched, inviting a limited number of participants to follow the MOOC. The target audience was the local student population in Nantes and potential participants to the ISI NucMed 2023 edition. Three non-European participants were also invited to participate, selected by the IAEA, to explore the potential interest of this MOOC for their training programme in developing countries. Through this pilot project, we aimed at the following:  Exploring the technical aspects (registration, visualisation of the videos, miscellaneous questions).  Collecting questions for the lecturers in the centralised mailbox, writing the answers, and populating the dedicated section on ExtraDoc.  Initiating a communication campaign about the MOOC.  Evaluating the participation according to the number of participants, the number of Open Badges, and the number of questions received. This pilot programme was publicised and discussed at the occasion of the PRISMAP Consortium Meeting 5 in Roskilde, Denmark, in June 2023. An extended presentation with discussion was animated by Anne Le Pennec (ARRONAX) in a closed session, and she made a further contribution during the public panel discussion on the new PRISMAP services. The pilot programme ran until 7 July 2023. Out of the 6 participants, 5 finished the MOOC and a total of 28 badges were earned. Furthermore, an exit questionnaire was used to gain feedback from the participants. Four of them answered the exit questionnaire (return rate: 66%) and expressed their high satisfaction with the quality of the MOOC's content, its scientific and educational interest, the evaluation process and the user-friendliness. This feedback also led to the correction of a number of bugs and the integration of a progress monitoring tool. The limited number of participants in the pilot did not allow to complete the FAQ page, which will rather be deployed as questions come from a larger and more diverse audience. 4.3 Deployment The MOOC was officially launched on Wednesday, 27 Sep 2023 and linked to the PRISMAP website, under Educational Resources. The MOOC was announced on the PRISMAP social media, and via the consortium. It will also be announced in the next PRISMAP newsletter and regularly promoted through these channels. 5. Conclusions The preparation of the MOOC At the heart of European medical radioactivity proved to be more challenging than expected, as it had to be re-created. Much of the content could be taken from an original MOOC at the Nantes Université, but most of the technical aspects had to be worked out from scratch. The MOOC was successfully introduced as a pilot project over the spring 2023 and explored by 6 participants. Figure 10: New version of the animated logo Clyde for the promotion of the MOOC. Deliverable D6.5 11 The MOOC is thus now ready for full deployment to the entire community. In the coming years, additional episodes will be added to the MOOC to reflect the expertise and interests from PRISMAP, ensuring that this MOOC remains at the state of the art and maintains its relevance for many generations of scientists to come. Its structure also allows its use for targeted activities in transdisciplinary training, hereby supporting the ambitions of the PRISMAP Training Office.