A. The modynamic ounda ions
One phase
(χ < 0)
Two phases
(χ > 0)
In e ac ion pa ame e (χ)
Concen a ion
C i ical Poin
Co e
(Long- e m memo y)
Pe cola ed ne wo k
Shell (Sho - e m memo y)
Decay enzymes
RNA
mRNA-modi ied
D. The memo y cycle: W i e, Read, E ase
WRITE
READ
ERASE
Encoding:
S ess signal ecogni ion
mRNA modi ica ion
Selec i e seques a ion
Re ie al:
Seconda y s ess esponse
Accele a ed adap a ion
Regula ed mRNA elease
Rapid ansla ion
Rese ing:
S ess e mina ion
Condensa e dissolu ion
Componen ecycling
C. Kine ic model o s a e ansi ions
S o age
(S)
Decay
(D)
Time
Decay a e
E. In eg a ion wi h cellula sys ems
Nucleus
Ac in ilamen s
Sca old p o eins
Nuclea po e
S ess g anules
SCAR/WAVE
Ribosome
WRITE
READ
ERASE
Plasma memb ane
Pe cola ed ne wo k
Condensa es
B. Sho and long- e m memo y model
Sca old p o eins
Decay enzymes
Decay enzymes
P ocessing bodies (S)
P ocessing bodies (D)
new p o eins
RNA decay
e ase/s o age
by condensa e in e ac ions
loading example
