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FEATURES OF THE CLINICAL COURSE OF HIV-
ASSOCIATED DERMATOSES IN CHILDREN
D.D. Nabiye a
Tashken S a e Medical Uni e si y
h ps://doi.o g/10.5281/zenodo.17693855
Abs ac . The aim o his s udy was o in es iga e he clinical cou se o HIV-associa ed
de ma oses in child en. Fi y child en wi h con i med HIV in ec ion we e obse ed. The s udy
analysed he s uc u e o skin diseases, hei clinical mani es a ions, incidence, and ela ionship
wi h he le el o immunode iciency. The da a ob ained allow o a mo e accu a e app oach o he
diagnosis and ea men o de ma oses in his pa ien popula ion.
Keywo ds: HIV, child en, de ma oses, immunode iciency, skin.
In oduc ion.
I is widely acknowledged ha HIV (human immunode iciency i us) in ec ion is a majo
global heal h issue. Acco ding o he Wo ld Heal h O ganiza ion (WHO), "...as o 2023,
app oxima ely 46 million people a e li ing wi h HIV in ec ion, and 14% o hese a e child en
unde 18 yea s o age...". Thei annual inc ease is 2.5-3 million. F om he i s de ec ion o HIV
in ec ion (1987) in Uzbekis an o Janua y 1, 2024, 77,127 cases ha e been egis e ed, and he
numbe o dea hs om a ious complica ions among HIV-in ec ed indi iduals is
app oxima ely 23,000 [1, 2, 3]. Acco ding o o icial s a is ics in ou coun y (Decembe 2024),
app oxima ely 47,000 people li e wi h HIV, 55% o whom a e men and 45% women. A high
pe cen age o hem su e om a ious skin diseases, which a e o en he i s clinical
mani es a ions o immunode iciency [3, 4, 5, 6].
HIV-associa ed de ma oses in child en include a wide ange o pa hologies: om
bac e ial and ungal skin in ec ions o i al lesions and in lamma o y diseases. Thei imely
ecogni ion is c ucial o diagnosis, choice o he apy, and e alua ion o ea men
e ec i eness. I has been shown h ough analysis ha HIV in ec ion emains one o he mos
signi ican global heal h issues wo ldwide, a ec ing millions o people on all con inen s and
ac oss all age g oups.
The li e a u e e eals ha domes ic and in e na ional li e a u e in ecen yea s has
e ealed ha he numbe o child en li ing wi h HIV wo ldwide emains signi ican . Skin
diseases in his ca ego y o pa ien s a e an impo an diagnos ic ma ke o he s age o
immunode iciency. S udying he cha ac e is ics o HIV-associa ed de ma oses in child en is
pa icula ly impo an , as i allows no only o he imely de ec ion o complica ions bu also
o he adjus men o he apeu ic s a egies [4, 5, 7, 8, 9]. In he Republic o Uzbekis an, his
p oblem is pa icula ly ele an due o he inc easing incidence and he need o imp o e he
sys em o medical ca e o child en wi h HIV.
Aim o he esea ch:
The s udy aims o s udy he clinical cou se o HIV-associa ed de ma oses in child en.
Objec i es o esea ch:
1. To de e mine he equency and pa e n o skin diseases in child en wi h HIV.
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INTERNATIONAL SCIENTIFIC JOURNAL VOLUME 4 ISSUE 11 NOVEMBER 2025
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2. To analyse he clinical mani es a ions o de ma oses depending on he s age o
immunode iciency.
3. De elop ecommenda ions o diagnosis and ea men .
Ma e ials and Me hods.
The s udy included 50 child en wi h a con i med diagnosis o HIV in ec ion, obse ed
a a specialized cen e . Clinical examina ions, labo a o y es s, and immune s a us (CD4 cell
coun s) we e pe o med. S a is ical da a p ocessing was pe o med using s anda d bios a is ical
me hods.
Resea ch esul s.
The mos common skin diseases in child en wi h HIV we e candidal lesions (40%),
bac e ial pyode ma (25%), i al skin in ec ions (20%), and alle gic de ma oses (15%).
Dis ibu ion o HIV-associa ed de ma oses in child en (Fig. 1). Dis ibu ion by
immunode iciency s age (Fig. 2).
Figu e 1. Dis ibu ion o HIV-associa ed de ma oses in child en
Figu e 2. Skin mani es a ions depending on he s age o immunode iciency
20
12 10 8
40% 25% 20% 15%
0
2
4
6
8
10
12
14
16
18
20
22
Кандидоз Пиодермии Вирусные
инфекции
Аллергические
дерматозы
Количесво случаев Процент (%)
15
20
10
5
20%40%60%280%
0
5
10
15
20
25
I -стадия II -стадия III -стадия IV-стадия
Количество детей Частота кожных заболеваний (%)
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Discussion.
I can be clea ly obse ed ha child en wi h HIV in ec ion expe ience ecu en
candidiasis, pa icula ly o he o al mucosa and pe ianal skin. Candidiasis ypically de elops as
ex ensi e, pain ul lesions p one o e osions and ulce a ions (Fig. 3 and Fig. 4).
In addi ion, candidiasis o la ge skin olds was no ed, beginning wi h he appea ance o
small supe icial se opu ulen phlyc enules. A e hese phlyc enules up u e, e osions o m,
which, g owing ou wa d, me ge, leading o he o ma ion o la ge e osions wi h sha ply de ined
polygonal edges, su ounded by an edema ous colla o he s a um co neum. These lesions we e
che y-b own in colo , he su ace emained mois , and c acks and accumula ions o a whi e, pas y
mass we e obse ed deepe wi hin. Small blis e s and pu ulen e up ions also appea ed a ound he
main lesion.
Figu e 3. Figu e 4.
No e: Pa ien s diagnosed wi h HIV in ec ion and como bidi ies: candidal s oma i is,
s ep ode ma, geni al candidiasis, and cu aneous candidiasis.
I has been shown h ough analysis ha hese esul s indica e a high p e alence o ungal
and bac e ial skin lesions in child en wi h HIV. The incidence o de ma oses inc eases as
immunode iciency p og esses. This con i ms he need o ea ly diagnosis and imely ea men o
skin diseases.
Conclusions
1. The mos common de ma oses in child en wi h HIV a e candidiasis and pyode ma.
2. The se e i y and equency o skin mani es a ions co ela e wi h he le el o
immunode iciency.
3. These esul s should be aken in o accoun when de eloping pa ien managemen
s a egies.
REFERENCES
1. WHO. HIV/AIDS and Skin Diseases in Child en. Gene a: Wo ld Heal h O ganiza ion, 2022.
2. WHO. HIV/AIDS ac shee . Gene a: Wo ld Heal h O ganiza ion, 2023.
3. UNAIDS. Global HIV & AIDS s a is ics — 2024 ac shee .
4. B own J., Smi h K. HIV-associa ed de ma oses in pedia ic pa ien s. Pedia ic De ma ology,
2021; 38(5): 742-750.
5. Sa a o B.A. HIV in ec ion in child en: clinical mani es a ions and diagnos ics. Tashken ,
2020.
6. Ka imo a N.M. Fea u es o he cou se o skin diseases in child en wi h immunode iciency.
Bulle in o De ma ology, 2021; 3: 45-52.
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7. Akh o o H.Kh., Nabie a D.D. T igge ac o s o a opic de ma i is in p eschool child en //
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