Frontiers Clinical and Translational Science Institute 2023 Annual Impact Report

2023 ANNUAL IMPACT REPORT ACCELERATING SCIENCE, IMPROVING HEALTHCARE FOR ALL ON THE FRONT COVER are representatives from Frontiers and its partners. Left to right, they are: Back Row: Steve Leeder, Frontiers Co-Director; Chris Wilson, The University of Kansas Health System; Garold Minns, University of Kansas School of Medicine-Wichita; Robert Simari, University of Kansas Medical Center; Tom Curran, Children’s Mercy Kansas City; Robert White, Kansas City University; Mario Castro, Frontiers Co-Director Front Row: MaryAnne Jackson, University of Missouri-Kansas City; Donna Buchanan, Saint Luke’s Health System; Frank Blecha, Kansas State University; Ed O’Connor, Kansas City University. 4 Welcome from the Co-Directors 5 Resources and Services 6 By the Numbers 8 Partners 10 Pilot Programs 14 Early Career Faculty Development Program 15 Predoctoral and Postdoctoral Training Program 16 Trainee Highlights 17 Training Opportunities 18 Event Highlights 19 Accomplishments 20 Community Engagement 21 Increasing Workforce Diversity Join us in our mission to advance science and improve healthcare for all by becoming a member. frontiersctsi.org/become-a-member Table of Contents As Co-Directors, we are pleased to present the Frontiers Clinical and Translational Science Institute report for the 2023 fiscal year. Here, we highlight the collaborative work of many people across our network of academic institutions, healthcare systems and community and patient advocacy groups. We are fully engaged with our partners in clinical and translational science innovations that improve health and healthcare for all. We encourage you to learn about our many endeavors and accomplishments, such as funding nearly 300 research projects, building numerous collaborations among scientists, patients and community organizations, training multiple K and T scholars and aiding in the design, implementation and communication of a wide range of research projects since 2011. In closing, we thank the faculty and staff who lead, support and contribute tireless work and dedication to Frontiers, with the aim of advancing clinical and translational science. We look forward to continuing to develop innovative resources and services to support our clinical and translational workforce and improve the health of our communities. Mario Castro, M.D., MPH Co-Principal Investigator and Director Steve Leeder, PharmD, Ph.D. Co-Principal Investigator and Director Watch our introduction video bit.ly/frontiersintro 4 | Frontiers Clinical & Translational Science Institute Services and Resources Frontiers services are organized into five initiatives to support our mission to advance science and improve healthcare for all. 1. Research Design and Analysis • Genomics • Informatics • Statistical Analysis and Planning • Data Management • Implementation Science 2. Research Support • Science Communication • Regulatory Knowledge and Suppport • Drug, Diagnostic and Medical Device Development • Evaluation and Impact • Budgeting and Finance 3. Clinical Research Facilities and Resources • Clinical and Translational Science Units (CTSUs) • Networking and Recruitment • Integrating Special Populations • Healthcare Integration • Workforce Development 4. Education, Training and Funding • Early Career Faculty Career Development (KL2 Awards) • Preand Postdoctoral Career Development (TL1 Awards) • Pilot Awards 5. Community and Collaboration • Team Science • Community Engagement Request a Service Consultation bit.ly/3PoU02C ACCELERATING SCIENCE, IMPROVING HEALTHCARE FOR ALL Our services are led by faculty from our partner institutions and are supported by Navigators serving as primary points of contact. Frontiers relies on the effort of over 90 faculty and staff to provide our many resources and services. Frontiers made structural changes to maximize our shared leadership model, including rebranding our logos and website to be more inclusive across our institutional partners. 2023 Annual Report | 5 By the Numbers 350+ service consultations delivered since June 2022 Members' Career Stages 83 Experienced Investigators (23%) 131 New Investigators (36%) 19 Postdoctoral Investigators (5%) 21 Graduate Student Trainees (6%) 5 Resident or Fellows (1%) 10 Medical Student Trainees (3%) 2 Undergraduate Students (<1%) 97 Other (26%) Members by Institution 208 University of Kansas Medical Center (46%) 81 Children’s Mercy Kansas City (18%) 40 The University of Missouri - Kansas City (9%) 27 University of Kansas Medical Center - Wichita (6%) 26 The University of Kansas (6%) 21 The University of Kansas Health System (5%) 16 Kansas City University (3%) 10 Other (2%) 7 Kansas State University (2%) 6 Saint Luke's Health System (1%) 5 Community Organizations (1%) 4 University of Kansas Medical Center - Salina (1%) 2 Private Industry (<1%) 90+ faculty and staff providing services and resources for our members 420+ members registered as of June 2023 6 | Frontiers Clinical & Translational Science Institute 539 publications attributed to Frontiers support since 2011 520+ active studies at CTSUs in grant year 2023 Members' Research Areas 57 Basic Research (14%) 30 Pre-Clinical Research (7%) 162 Clinical Research (39%) 43 Implementation Research (10%) 53 Population-Based Research (13%) 71 Non-Research Staff and Community Partners (17%) 4,000+ attendees at Frontiers hosted events in grant year 2023 7,900+ participant visits across all five Clinical Trial Service Units (CTSUs) during grant year 2023 145 events hosted by Frontiers in grant year 2023 Throughout the past year, Frontiers has continued to build its network. Here are a few highlights of the accomplishments Frontiers has achieved. 2023 Annual Report | 7 Partners Regional We are funded from a $27 million grant from the National Institute of Health’s National Center for Advancing Translational Sciences. Partners contribute $10 million in cost-share funds to the grant. Our eight academic and healthcare delivery institutions serve the entire state of Kansas and western Missouri. Geographic Coverage This map represents the territory that the Frontiers program covers in relation to Clinical and Translational Science Award (CTSA) programs in the Northeast (17 CTSA programs). Kansas Missouri 8 | Frontiers Clinical & Translational Science Institute National Impact As part of the National Center for Advancing Translational Sciences (NCATS) CTSA program, Frontiers investigators have the opportunity to collaborate with investigators from other CTSA programs. Below are the institutions Frontiers investigators have collaborated with over the past grant year. Learn why our partners choose to support our mission bit.ly/frontierspartners University of Iowa University of Kentucky University of Arkansas for Medical Sciences Duke University Michigan Institute for Clinical and Health Research Georgetown University Arizona State University The Pennsylvania State University University of New Mexico Health Sciences Center Indiana University University of Utah Health Developing Stay Conversations CORES Consortium of Rural States Genomics Stakeholder Project Developing a CTSA Research Network to Support Translational Science Across the Criminal Justice Continuum Evaluating sleep disturbances in adolescents and young adults with intellectual and developmental disabilities 2023 Annual Report | 9 Trainee Highlights 82 Frontiers Trainees and Scholars since 2011 34 Predoctoral Scholars (TL1) 17 Postdoctoral Scholars (TL1) 31 Early Career Scholars (KL2) Top Poster winner ACTS 2023 Jada Ohene Agyei, TL1 Trainee from the University of Missouri-Kansas City, was awarded Top Poster at the Association of Clinical and Translational Sciences 2023 conference. 776+ total publications from all K & T Program Scholars since 2011 Our previous trainees have gone on to other institutions around the nation, including: University of Washington University of Nevada-Las Vegas University of Kentucky University of Chicago University of Colorado-Boulder Children’s Hospital of Philadelphia Loyola Medicine as well as private clinical practice and private industry 96% of Frontiers Scholars (K & T program) have secured independent funding since the conclusion of their training 16 | Frontiers Clinical & Translational Science Institute Training Opportunities Mock Study Sections Twice a year, Frontiers holds a Mock Study Section (MSS). The MSS simulates an NIH study section, reviewing K and R grants submitted by faculty from our partner institutions. Participants receive valuable feedback from in their fields; not only increasing probability of funding, but also fostering collaboration and resource sharing. Team Science Training Workshop In May of 2023, our Team Science group brought in expert and External Advisory Board member, Jeni Cross, Ph.D. to lead our group in Team Science Training. In attendance were 19 participants from our partner institutions. High School Summer Training in Academic Research: STAR 2.0 Program The STAR 2.0 Program provides a hands on, high quality research experience during the summer academic break for high school students and educators. During the program, participants get the chance to: • Work with a Children’s Mercy Kansas City faculty on an original research project. • Develop a research publication for submission to a peer reviewed journal. • Learn about clinical and translational research methodology, writing, statistics, medical ethics and career development. • Network and learn with other students/educators. This summer, our Informatics team hosted five interns. Our program manager also taught a scientific writing course for all trainees. Mock Study Section STAR 2.0 Program 2023 Annual Report | 17 Event Highlights Research Symposium Grant Renewal Celebration Grant Renewal Celebration Hosted at the World War 1 Museum and Memorial, the renewal celebration featured speakers from all partner institutions, networking opportunities and tours of the Museum and Memorial. View event highlights: bit.ly/2023grantrenewal Research Symposium Frontiers hosted a hybrid Research Symposium on Communicating Science in the Community to approximately 160 investigators, community members and research staff. Speakers from across the country presented best practices on research to communities. The Symposium also included oral presentations and poster sessions featuring Pilot Awardees, Early Career Faculty and Predoctoral and Postdoctoral trainees in the TL1 program. View event highlights: bit.ly/2023researchday Research and Discovery Grand Rounds Topics this year included: • Mentorship • Team Science • Community Engagement • Patient Reported Outcomes • Pilot Funding Opportunities • Scientific Workforce Diversity View past seminars: bit.ly/RDGRlist 18 | Frontiers Clinical & Translational Science Institute Clinical and Translational Science Units Expansion We added KUMC Swope to our Clinical Trial Service Units this year. This new site provides 1,000 sq. ft. of clinical space, including an additional exam room, two flex rooms and infusions space. It also adds administrative staff. Located in a predominately Black community, this site expands Frontiers’ researchers access to research services and education to Kansas Citians that have been underrepresented and historically excluded in clinical research. Institute for Advancing Medical Innovation The Institute for Advancing Medical Innovation recently collaborated with a pharmaceutical company (CicloMed LLC) to work on drug development for cancer treatment. Their studies investigated a drug’s safety and dosage in bladder cancer patients. Based on positive results from these trials, additional funding has been applied for to continue studying the drug’s effect in additional patients with bladder cancer. Clinical Trial Finder Application The University of Kansas Medical Center Data Science team has developed an app that allows patients and their physicians to easily browse through active trials within the Frontiers network by retrieving trial information from the clinical trial management system. Currently Clinical Trial Finder accesses cancer, pulmonary critical care and neuromuscular trials. Genomics 10x Symposium Our Genomics core hosted a symposium in December 2022 to expand access and awareness of advanced genomics technologies among the broader translational research community. The symposium featured 10x Genomics, an industry leader in single cell and spatial sequencing. Presentations were also delivered by investigators at Children’s Mercy Kansas City, KUMC and UMKC. Over 68 attendees participated in the event. Improved Survey Accessibility Informatics has developed and implemented two user-friendly tools: Accomplishments MyCap A mobile-friendly integration of RedCap (Research and Data Capture Process) forms. MyCap allows study participants to answer surveys from their phones, faciliting efficient data collection for both researchers and participants. Geomarker A self-service portal that allows researchers to record patients’ addresses, an important social determinant of health, in a secure, private manner. Patient at the new CTSU at KUMC Swope Frontiers Clinical Trial Finder App 2023 Annual Report | 19 Community Engagement JUNTOS JUNTOS (Spanish for “together”) is a center focused on building community-academic partnerships to improve the health of Latinos. From a sustained base of authentic relationships in Latino communities, JUNTOS advances health through alliances in research, service and education in a culturally relevant way. Multidisciplinary Advocates and Research Group (MARG) The Multidisciplinary Advocates and Research Group (MARG) is a mix of community engaged researchers and community member advocates working to foster community engagement in projects. In monthly meetings,the MARG discusses best practices and provides advice to investigators and their community partners. The MARG also meets in person after hours for networking events to connect community and investigators across disciplines. Innovations in Quality Forums (IQ Forums) Initiated in 2017 as the Kansas City Quality and Value Innovation Consortium (KC QVIC), their work began with discussions among healthcare leaders that resulted in active, multi-stakeholder collaborations focused on addressing challenges impacting the effectiveness, cost and equity of healthcare for the region. Since then, there have been 50+ Innovations in Quality Forums that have provided the regional healthcare community a place to exchange ideas focused on improving the quality and value of healthcare for Kansas City to over 3,000 attendees. Topics have included the role of data in the evolution of healthcare, addressing holes in society’s safety nets, maternal health and mortality, caregiving trends, burdens and breakthroughs, long haul covid and rural health models and innovations. These collaborations, and the quality improvement projects that they launched, grew at a pace that required investment in infrastructure. Recognizing the value of these efforts and their need for robust infrastructure, the University of Missouri System leadership awarded the KC QVIC “institute” status under the University of Missouri – Kansas City, thus creating the Healthcare Institute for Innovations in Quality in 2021. 1,200+ Covid-19 vaccines delivered 550 Covid-19 tests administered 3,300 people reached 42 vaccination clinics in low vaccine rate communities Innovations in Quality Forum 20 | Frontiers Clinical & Translational Science Institute 4.7% of our members identify as having a physical or mental impairment as defined by the ADA 6.6% of our members identity as part of the LGBTQ+ community Increasing Workforce Diversity Diverse workplaces create more innovative and effective interventions for our entire population. Frontiers advocates and facilitates the recruitment, retention and overall success of a diverse workforce across all partner institutions. Building an inclusive environment where diversity is valued as an essential asset for generating knowledge that most benefits the diverse populations that we serve, like the efforts made through JUNTOS, is a key facet of Frontiers work. 20.3% of members come from a NIH disadvantaged background 5.2% of members identify as Hispanic/Latino 25% of our trainees and 13.8% of members are from racial or ethnic backgrounds that are underrepresented in medicine and research, compared to the national average of 13% of medical school faculty in medicine and STEM according to the American Association of Medical Colleges. Racial and Ethnic Makeup of Frontiers Membership 11 American Indian or Alaska Native (2%) 58 Asian (15%) 32 Black or African American (8%) 2 Native Hawaiian or Other Pacific Islander (<1%) 264 White (68%) 7 Different Identity (2%) 14 Prefer not to say (3%) 1 in 5 of our trainees come from disadvantaged socioeconomic backgrounds as defined by NIH 64% of our trainees and 60.1% of our members identify as female 2023 Annual Report | 21 Cite Our Grant Research reported in this publication was supported by the National Center for Advancing Translational Sciences of the National Institutes of Health under the Award Numbers UL1TR002366, KL2TR002367 and TL1TR002368. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. Become a Frontiers Member! Open to all clinical and translational investigators and staff members at our partner institutions. Membership is free and entitles you access to all the resources, funding and events that Frontiers has to offer. frontiersctsi.org/become-a-member Already a Member? Request a service consultation. bit.ly/3PoU02C 22 | Frontiers Clinical & Translational Science Institute Contact Us 913-588-6290 [email protected] frontiersctsi.org 4330 Shawnee Mission Parkway, Suite 3220 Mail Stop 7003 Fairway, Kansas 66205 Accelerating Science, Improving Healthcare for All @frontiersctsi7926@FrontiersCTSI @FrontiersCTSI Frontiers CTSI