Mycosis fungoides associated to HTLV-1 infection in a Peruvian cohort: a case series (P071)
Bravo, Francisco; Conde, Francisco; Ramos, Cesar; Garrido-Pinzás, Gabriela; Salinas, César; Cok, Jaime; Mejía, Fernando; Seas, Carlos; Gotuzzo, Eduardo
- Publisher
- Zenodo
- Language
- en
Abstract
BACKGROUND The relationship between human T-lymphotropic virus type 1 (HTLV-1) and mycosis fungoides, a type of cutaneous T-cell lymphoma, remains obscure. While HTLV-1 infection has been closely associated with adult T-cell leukemia/lymphoma (ATLL), there is limited data on its relationship to other cancers derived from the immune system, such as mycosis fungoides. Here, we aim to present a retrospective case series of Peruvian patients with HTLV-1 infection who were also diagnosed with mycosis fungoides. METHOD We conducted a secondary data analysis to investigate the association of mycosis fungoides and HTLV-1 in patients at Hospital Nacional Cayetano Heredia and the Instituto de Medicina Tropical Alexander von Humboldt (IMTAvH) in Lima, Peru. Demographic information, clinical records, laboratory reports, and biopsy reports (e.g., skin, bone marrow, lymph nodes) were reviewed. Current status was checked using national registers. We used descriptive statistical methods to obtain the results. RESULTS We describe 26 patients with mycosis fungoides and HTLV-1. Of these, 9 (35%) were male and 17 (65%) female. Regarding ethnicity, 12 (46%) were mixed race, 11 (42%) were Andean, 1 (3%) was white, 1 (3%) Asian, and 1 (3%) unspecified. The median age at HTLV-1 diagnosis was 63 years (IQR 53–73.5), and the median age at mycosis fungoides diagnosis was 65 years (IQR 54–75). Eight (30%) were alive at last follow-up, 16 (61%) were deceased, and 2 were lost to follow-up. Regarding other HTLV-1–associated manifestations, 6 patients (23%) had infective dermatitis, 1 (3%) had scabies, and 1 (3%) had HTLV-1–associated myelopathy/tropical spastic paraparesis (HAM/TSP). CONCLUSION Through this data we describe a possible association between HTLV-1 and cutaneous T-cell lymphoma/mycosis fungoides. This is a poorly recognized association; to our knowledge, there are not many reports of these two entities. Further studies should be conducted to clarify the relationship between them. Additionally, we suggest that in countries with high prevalence of HTLV-1, patients with newly diagnosed mycosis fungoides should be assessed for HTLV-1 as well.
Full text
P071 Mycosis fungoides associated to HTLV-1 infection in a Peruvian cohort: a case series Dr Francisco Bravo1, Dr Francisco Conde1, Dr Cesar Ramos2,1, Dr Gabriela Garrido-Pinzás1, Dr Cesar Salinas3, Dr Jaime Cok2, Dr Fernando Mejía1,2, Dr Carlos Seas1,2, Dr. Eduardo Gotuzzo1 1Instituto de Medicina Tropical Alexander von Humboldt (IMTAvH)-Universidad Peruana Cayetano Heredia (UPCH), Lima, Peru. 2Hospital Nacional Cayetano Heredia, Lima, Peru. 3Clínica Cayetano Heredia, Lima, Peru Background The relationship between human T-lymphotropic virus type 1 (HTLV-1) and mycosis fungoides, a type of cutaneous T cell lymphoma remains obscure. While HTLV-1 infection has been closely associated to adult T cell lymphoma (ATLL), there is limited data on its relationship to other type cancers derived from the immune system such as Mycosis fungoides. Here we aim to present a retrospective case series of Peruvian patients with HTLV-1 infection who were also diagnosed with mycosis fungoides. Method We did a secondary data analysis to investigate the association of mycosis fungoides and HTLV-1 diagnosis on patients at the Hospital Nacional Cayetano Heredia and the Instituto de Medicina Tropical Alexander von Humboldt (IMTAvH) in Lima, Peru. Demographic information, clinical records, laboratory reports and biopsy reports (e.g., skin, bone marrow, ganglia). Current status was checked using national registers. We used descriptive statistics methods to obtain the results. Results We describe 26 patients with Mycosis fungoides and HTLV-1. Of these patients, 9 (35%) were male and 17 were female (65%). Regarding their ethnicity, 12 (46%) were mixed race, 11 (42%) were Andean, 1 (3%) was white, 1 (3%) was Asian and 1 (3%) unspecified. The median age at HTLV-1 infection diagnosis was 63 years (IQR 53 - 73.5) and the median age at mycosis fungoides diagnosis was 65 years (IQR 54 – 75). 8 of them (30%) are living, 16 (61%) are deceased and 2 were lost to follow-up. Additionally, regarding other HTLV 1-associated manifestations 6 patients (23%) had infective dermatitis, 1 (3%) had scabies and 1 (3%) had HTLV1associated myelopathy/tropical spastic paraparesis (HAM/TSP). Conclusion Through this data we describe a possible association between HTLV-1 and Cutaneous T cell lymphoma/mycosis fungoides. This is a poorly recognized association, to our knowledge there are not many reports of these two entities. Further studies should be done in order to clarify the relationship
between them. Additionally, we suggest that in countries with high prevalence of HLTV-1, patients with newly diagnosed Mycosis fungoides should be assessed for HTLV-1 as well. Keywords ["Diagnostics","Epidemiology","Oncology, Other"]
