Sub-second and Dynamic Compu ed Tomog aphy De elopmen a he Canadian Ligh Sou ce
Xiao Fan Ding 1, Chen Li 3, Li eng Zhang 3, Ning Zhu 1, 2, 3
1 Depa men o Biomedical Enginee ing, Uni e si y o Saska chewan, SK, Canada, 2 Canadian Ligh Sou ce Inc., SK, Canada,
3 Depa men o Chemical and Biological Enginee ing, Uni e si y o Saska chewan, SK, Canada
In oduc ion: Dynamic CT is an eme ging echnique o unin e up ed acquisi ion o adiog aphic p ojec ions o
a sample as i o ms, de o ms, o in e ac s o ex e nal condi ions 1. Howe e , a basic p inciple o co ec
omog aphic econs uc ion is ha he sample emain unchanged du ing CT acquisi ion o a oid mo ion a e ac s.
To cap u e dynamic p ocesses, ei he he sample s abili y is con olled abo e he limi a ions o he cap u e de ice,
o omog aphic da a needs o be acqui ed as e 1, 2. The o me is used in dynamic CT join s udies h ough
p ecisely con olled join mo emen s a clinical scanne s 3. The Canadian Ligh Sou ce (CLS) uses he la e
app oach as he high lux is se e al o de s o magni ude g ea e han labo a o y X- ay sou ces and well sui ed o
sub-second acquisi ions 1, 4. The g ea e empo al esolu ion allows o omog aphic econs uc ion o an e ol ing
sample and he changing in e nal s uc u es can be cap u ed and isualized 1. Dedica ed mic o-CT sys ems a e
also capable o dynamic CT wi h scans on he o de o 2 CTs/min 5. Compu a ional and mechanical cons ain s
limi dynamic CT s udies o small samples o sho pe iods o ime. Resea ch applica ions ha e been in ma e ial
sciences and p elimina y s udies in small animals and medical implan design 1, 3, 6. In his abs ac , dynamic CT
was used o isualize he we g anula ion p ocess o pha maceu ical powde s once in con ac wi h wa e .
Me hods: This s udy was pe o med a he 05B1-1 beamline a he CLS wi h a pho on lux densi y o 1012
pho ons/mm2/s in a il e ed whi e beam. P ojec ions o 2000×664 px a 5.3 μm/px we e cap u ed by a Hamama su
AA-40 beam moni o wi h a 200 μm hick LuAG scin illa o coupled o a PCO.DIMAX HS4 came a. Wi h a 50
cm sample- o-de ec o dis ance, each indi idual scan consis ed o 500 p ojec ions o e 180° in 0.5 s. The we
g anula ion expe imen consis ed o a mic opipe e o deionized wa e , con olled by a sy inge pump, held 2.5 cm
abo e he powde bed. On a mo o ized o a ion s age, cylind ical essels con aining he powde s we e posi ioned
26 m away om he ligh sou ce. Two pha maceu ical powde s, lac ose monohyd a e (LMH) and mic oc ys alline
cellulose (MCC), we e scanned o 20 and 13 s espec i ely once he wa e d ople con ac ed he powde bed.
Wi h a 1 ms empo al esolu ion, indi idual momen s o he g anula ion p ocess we e econs uc ed h ough
selec ions o 500 consecu i e p ojec ions. This allowed o cha ac e is ics such as he consolida ion o he g anule
shape and he subsequen g ow h o po es o be isualized in anima ions wi h 1 ms in e al be ween ames.
Resul s: In a single slice, he g anule consolida ed i s shape o LMH (Fig 1 c) and less so o MCC (Fig 1 d)
while bo h became mo e po ous o e he elapsed scan ime. Focused on a sample a ea consis ing o only solid
g anule, he o al po e a ea in he sample was plo ed o e he scan ime (Fig 1 e). Bo h g anules g ew du ing
we ing howe e he MCC g anule sp ead a he ou wa d. Bo h samples sh ank as po es o med (Fig 1 ).
Fig 1: The ea ly, middle, and la e s ages o we ing and nuclea ion a e shown o LMH (a, c) and MCC (b, d). Sample po e a ea and g anule
a ea o e he elapsed scan ime o LMH in blue and MCC in ed (e, ).
Conclusions: This abs ac aimed o illus a e he dynamic CT capabili ies a he CLS. The high- lux X- ays and
high-speed came a can acqui e a ull omog aphic da ase in 0.5 s. The dynamics o we g anula ion we e
econs uc ed wi h a empo al esolu ion o 1 ms. The e we e signi ican mo ion a e ac s du ing he we ing due
o d ople mo ion. The subsequen nuclea ion was be e isualized wi h analysis on he g anule shape and po osi y.
Fas e da a acquisi ion a he CLS is easible o 0.5 ms esolu ion which may mi iga e he pe sis ence o mo ion
a e ac s du ing we ing.
1 Dewanckele e al (2020). J. Mic osc, 2 Mokso e al (2011). AIP Con . P oc., 3 Kuczynski e al (2020). Albe a BME Con e ence, 4 Pa e son
e al (2016). J. Ma e . Sci., 5 Manuel e al (2014). Nucl. Ins um. Me hods Phys. Res., B, 6 Fa din e al (2018). Eu . Respi . J.
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Imaging Ne wo k On a io Symposium 2021 P oceedings
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