Mo i a ion and In oduc ion
Acknowledgemen s and Re e ences
Ou pu s and Vision
Concep and Resul s – Wo kshops & T aining Schools
Leading Enginee ing S uden s Towa ds Indus y 4.0: Public Wo kshops o
Digi aliza ion, Lab Au oma ion, and Modelling
R. Haß u he a, A. Kemme a, P. Neubaue a,c , M. N. C uz Bou nazoua,b, C. L. Ga galod, K.V. Ge naeyd,
D.M.F. P aze ese, A. Aze edoe
a
Technische Uni e si ä Be lin, Chai o Biop ocess Enginee ing, Acke s aße 76, 13355 Be lin
b
Da aHow AG, Vladimi -P elog-Weg 1, 8093 Zu ich
c
Enp esso GmbH, F ohnaue S . 59, 13467 Be lin
d
Technical Uni e si y o Denma k, PROSYS, Søl o s Plads, 228 A, DK-2800 Kgs. Lyngby
e
Ins i u o Supe io Técnico,Uni e sidade de Lisboa, iBB G oup, A . Ro isco Pais1049-001 Lisboa
We g a e ully acknowledge he inancial suppo p o ided by HORIZON-WIDERA-2023-ACCESS-02 o he Dig4Bio p ojec (p ojec -ID 101159993). Fu he we acknowledge he suppo and con ibu ions om ou colleagues and membe s o he
KIWI-Biolab ha made his esea ch possible.
[1] Udugama, I.A. e al. (2023) ‘Digi al ools in chemical enginee ing educa ion: The needs and he desi es’, Educa ion o Chemical Enginee s, 44, pp. 63–70. doi.o g/10.1016/j.ece.2023.05.002.
[2] ‘Dig4Bio’ (2025). A ailable a : h ps://dig4bio.eu/ (Accessed: 10 Feb ua y 2025).
[3] Ga galo, C.L. e al. (2022) ‘Educa ional Compu e -Aided Tools Towa ds Indus y 4.0: Recommenda ions and BioVL’, in Compu e Aided Chemical Enginee ing. Else ie , pp. 1273–1278. doi.o g/10.1016/B978-0-323-85159-6.50212-8.
[4] Caño De Las He as, S., Ga galo, C. L., Wei ze, C. L., Mansou i, S. S., Ge naey, K. V., & K ühne, U. (2021). A amewo k o he de elopmen o Pedagogical P ocess Simula o s (P2Si) using explana o y models and gami ica ion. Compu e s &
Chemical Enginee ing, 151, 107350. h ps://doi.o g/10.1016/j.compchemeng.2021.107350
[5] Slide by Mads S e nsbo g, DTU
[6] h ps://c ea i ecommons.o g/abou /downloads/ (accessed on 25.08.2025)
[7] Slide by Fiamme a Caccia ale, DTU [8] A. Fulle , Z. Fan, C. Day and C. Ba low, "Digi al Twin: Enabling Technologies, Challenges and Open Resea ch," in IEEE Access, ol. 8, pp. 108952-108971, 2020, doi: 10.1109/ACCESS.2020.2998358.
•Ve y posi i e o e all eedback; many pa icipan s s a ed hey wan o join Dig4Bio’s u u e wo kshops.
•Wo kshop and aining school con en has now been included in IST cou ses.
•Planned wo kshops - mo e in o on he Dig4Bio websi e di4bio.eu Dig4Bio LinkedIn Page
•Wo kshop “Design and Ope a ion o Expe imen s in pa allel sys ems” will ake place on 01-02 Oc obe 2025
•Wo kshop “In oduc ion o compu e -aided ools o p ocess design” will ake place on 23-26 Feb ua y 2026
•The e en s each undamen als o digi aliza ion in biomanu ac u ing o en no co e ed by s anda d cou ses.
T aining school - Ad anced use o BioVL and
e-lea ning ools
This aining school co e ed i ual labo a o ies (VLs).
VLs ha e inc easingly become a common educa ional
ool in eg a ed in o he cu iculum in his new e a
ma ked by echnological ad ances and lexible
educa ion.
Wo kshop - Labo a o y
au oma ion
This i ual wo kshop aimed o
p o ide a comp ehensi e o e iew on
solu ions o labo a o y au oma ion,
including liquid handling si es o
au oma ed cul i a ions o analy ics.
T aining school - Mechanis ic
modeling o mic obial
cul i a ions
This hyb id aining school aimed o
explo e he in icacies o mechanis ic
modelling o mic obial cul i a ions using
biological eac ion a e models, including
selec ing an ini ial model s uc u e and
de e mining model pa ame e alues
using example da ase s.
Wo kshop - Resea ch da a
managemen and open science
This i ual wo kshop in oduced ools
o suppo he ep oducibili y and
ans e o da a, emphasizing he FAIR
p inciples ( indable, accessible,
in e ope able, and eusable) o da a
and p ocesses. I also co e ed he use
o seman ic p ocess modelling.
TS2: Ad anced use
o BioVL and
e-lea ning ools
TS3: In oduc ion
o au oma ed
esea ch
WS1:
In oduc ion
o py hon
WS2: Model-based
echniques
WS3: Labo a o y
au oma ion
WS4: Da a managemen
Plans
WS5: Resea ch
da a managemen
and open science
WS6:
In oduc ion
o ELNs and
LIMS
WS7:
In oduc ion o
compu e aided
ools o p ocess
design
WS8: Design and
Ope a ion o
Expe imen s in
pa allel Sys ems
WS9: Consis en
biop ocess
de elopmen
TS1: Mechanis ic
modeling o mic obial
cul i a ions
Wo kshops and
aining schools
Key lea nings:
•In oduc ion o simula ion pla o m
BioVL [3]
•Hands-on expe ience wi h BioVL
•O he ools and e- lea ning pla o ms
Take aways:
•12 pa icipan s –O e all high sa is ac ion
•Pa icipan s asked o mo e hands-on exe cises
Key lea nings:
•In oduc ion o
obo ic labs and
au oma ion
so wa e
•C ea ing pipe ing
sc ip s in he Tecan
liquid handling si e
Take aways:
•11 pa icipan s – O e all
high sa is ac ion
•Applicabili y o he
so wa e and
demons a ion o
examples, we e
highly alued
Take aways:
•12 pa icipan s – O e all high sa is ac ion
•Pa icipan s ound he scena ios o license usage and
p ac ical exe cises, including small asks, mos use ul.
Key lea nings:
•FAIR p inciples and bes
p ac ice o open access
and da a sha ing
•Tools o da a ep oducibili y
•In oduc ion o seman ic
p ocess modeling
Take aways:
•28 pa icipan s – high O e all sa is ac ion
•P ac ical examples and hands-on exe cises we e
consis en ly highligh ed as ex emely use ul.
Key lea nings:
•In oduc ion o key
g ow h phases and
pa ame e s, pa ame e
es ima ion and
sensi i i y analysis
[5]
[6]
[4]
[8]
The Digi al Gap – Enginee ing inc easingly elies on compu a ional ools, ye cu icula o en lack s uc u ed app oaches o build digi al and
p og amming li e acy (1).
Closing he Gap – The Dig4Bio p ojec (Ins i u o Supe io Técnico Lisbon, Technical Uni e si y Be lin and Denma k‘s Technical Uni e si y)
esponds wi h 22 mon hs o wo kshops and aining schools (2).
A Digi al Toolbox – These ac i i ies equip s uden s and young esea che s wi h essen ial digi al skills ha accele a e biop ocess de elopmen
h ough sys ema ic and model-based app oaches.
Lessons Lea n – Pa icipan eedback is sys ema ically collec ed and analyzed. Based on hese indings, we p opose a s a egy o in eg a ing
p og amming and digi al me hods in o enginee ing educa ion in ways ha align wi h bo h indus y needs and s uden expec a ions.
Visi lec u e o pos e p esen a ions om o he membe s o Dig4Bio a :
•L. Mölle ‘s alk on V. na iegens po en ial o plasmid p oduc ion - Tue 12.35 in
Audi o ium III
•P1.001 - L. Gunde sen – Pos e on g ow h models o V. na iegens
•Discussion on AI in Educa ion led by F. Cacca ale – Tue 10:35 in oom 3.B
•P4.049 - A. San os – Pos e on DNA-o igami nanos uc u es
•P2.016 - R. Hass u he – Pos e on Digi aliza ion in Educa ionc
