ToxTempAssistant: Using Large Language Models to Standardise Cell-Based Toxicity Test Method Descriptions

This form is distributed under a Creative Commons 4.0 BY licence Author information Name: Jente M. Houweling Date: 2025-09-16 Title of manuscript: ToxTempAssistant: Using Large Language Models to Standardise Cell-Based Toxicological Test Method Descriptions Contribution to the Publication Conceptualization, Methodology, Software, Validation, Data Curation, Visualisation, Writing - Original draft Interests Please select “Yes” or “No” next to any interests below that are relevant to your situation Financial interests Do you, your family, close relations or acquaintances, currently have, have had in the last 5 years, or expect to have in the next 2 years, any financial interests (potential gains or losses) that could be affected by your submitted publication? Non-financial interests Do you have any of the following interests that could potentially influence or be affected by your submitted publication? No From employment or provision of services, such as directorships, consultancy, honoraria, etc. No Current and previous research findings or projects No From intellectual property, such as patents, copyrights, etc. No Commitments to specific standards or processes No From investments such as shares, stocks, other financial instruments, etc. No Publicly held positions or statements of public record No From litigation or legal cases Yes Personal relationships No From grants No Membership or active role in other organisations, e.g. societies, lobby or pressure groups, government agencies, etc. No Other financial interests No Position of authority in an organisation, such that you may be seen as upholding that organisation's views, standards, values, etc. No Other non-financial interests Please provide details about the financial interests you have indicated above Not applicable. 1 This form is distributed under a Creative Commons 4.0 BY licence Please provide details about the non-financial interests you have indicated above I declare a personal relationship with the second author of this manuscript. 2 This form is distributed under a Creative Commons 4.0 BY licence Author information Name: Matthias M. L. Arras Date: 2025-09-16 Title of manuscript: ToxTempAssistant: Using Large Language Models to Standardise Cell-Based Toxicological Test Method Descriptions Contribution to the Publication Software, Writing - Review & Editing, Visualisation Interests Please select “Yes” or “No” next to any interests below that are relevant to your situation Financial interests Do you, your family, close relations or acquaintances, currently have, have had in the last 5 years, or expect to have in the next 2 years, any financial interests (potential gains or losses) that could be affected by your submitted publication? Non-financial interests Do you have any of the following interests that could potentially influence or be affected by your submitted publication? No From employment or provision of services, such as directorships, consultancy, honoraria, etc. No Current and previous research findings or projects No From intellectual property, such as patents, copyrights, etc. No Commitments to specific standards or processes No From investments such as shares, stocks, other financial instruments, etc. No Publicly held positions or statements of public record No From litigation or legal cases Yes Personal relationships No From grants No Membership or active role in other organisations, e.g. societies, lobby or pressure groups, government agencies, etc. No Other financial interests No Position of authority in an organisation, such that you may be seen as upholding that organisation's views, standards, values, etc. No Other non-financial interests Please provide details about the financial interests you have indicated above Not applicable. 3 This form is distributed under a Creative Commons 4.0 BY licence Please provide details about the non-financial interests you have indicated above I declare a personal relationship with the main other and as a scientist working professionally with large language models, my contribution to the technical implementation arose naturally. Although I have left academia, I remain actively engaged in publishing, motivated by my continued interest in the academic process and in authoring scientific work. 4 This form is distributed under a Creative Commons 4.0 BY licence Author information Name: Egon L. Willighagen Date: 2025-09-01 Title of manuscript: ToxTempAssistant: Using Large Language Models to Standardise Cell-Based Toxicological Test Method Descriptions Contribution to the Publication Supervision, Funding acquisition, Writing - Review & Editing; Interests Please select “Yes” or “No” next to any interests below that are relevant to your situation Financial interests Do you, your family, close relations or acquaintances, currently have, have had in the last 5 years, or expect to have in the next 2 years, any financial interests (potential gains or losses) that could be affected by your submitted publication? Non-financial interests Do you have any of the following interests that could potentially influence or be affected by your submitted publication? No From employment or provision of services, such as directorships, consultancy, honoraria, etc. No Current and previous research findings or projects No From intellectual property, such as patents, copyrights, etc. No Commitments to specific standards or processes No From investments such as shares, stocks, other financial instruments, etc. No Publicly held positions or statements of public record No From litigation or legal cases No Personal relationships No From grants No Membership or active role in other organisations, e.g. societies, lobby or pressure groups, government agencies, etc. No Other financial interests No Position of authority in an organisation, such that you may be seen as upholding that organisation's views, standards, values, etc. No Other non-financial interests Please provide details about the financial interests you have indicated above Not applicable. Please provide details about the non-financial interests you have indicated above LLMs are heavily debated in which I partake. I recently signed a Dutch letter against the uncritical adoption of LLMs (and other AI) at universities [0]. This public debate has a clear 5 This form is distributed under a Creative Commons 4.0 BY licence link to this paper, but they are not conflicting and I believe the debate helped the critical evaluation of this work. Specifically, publication or not of this paper does not neither affect other efforts in the past period nor in the next two years. 0.https://openletter.earth/open-letter-stop-the-uncritical-adoption-of-ai-technologies-in-acade mia-b65bba1e 6 This form is distributed under a Creative Commons 4.0 BY licence Author information Name: Danyel Jennen Date: 2025-09-17 Title of manuscript: ToxTempAssistant: Using Large Language Models to Harmonise Cell-Based Toxicological Test Method Descriptions Contribution to the Publication Conceptualization, Writing - Review & Editing; Interests Please select “Yes” or “No” next to any interests below that are relevant to your situation Financial interests Do you, your family, close relations or acquaintances, currently have, have had in the last 5 years, or expect to have in the next 2 years, any financial interests (potential gains or losses) that could be affected by your submitted publication? Non-financial interests Do you have any of the following interests that could potentially influence or be affected by your submitted publication? No From employment or provision of services, such as directorships, consultancy, honoraria, etc. No Current and previous research findings or projects No From intellectual property, such as patents, copyrights, etc. No Commitments to specific standards or processes No From investments such as shares, stocks, other financial instruments, etc. No Publicly held positions or statements of public record No From litigation or legal cases No Personal relationships No From grants No Membership or active role in other organisations, e.g. societies, lobby or pressure groups, government agencies, etc. No Other financial interests No Position of authority in an organisation, such that you may be seen as upholding that organisation's views, standards, values, etc. No Other non-financial interests Please provide details about the financial interests you have indicated above Not applicable. Please provide details about the non-financial interests you have indicated above Not Applicable 7 This form is distributed under a Creative Commons 4.0 BY licence Author information Name: Anne Kienhuis Date: 2025-09-17 Title of manuscript: ToxTempAssistant: Using Large Language Models to Standardise Cell-Based Toxicological Test Method Descriptions Contribution to the Publication Supervision, Funding acquisition, Conceptualization, Writing - Review & Editing. Interests Please select “Yes” or “No” next to any interests below that are relevant to your situation Financial interests Do you, your family, close relations or acquaintances, currently have, have had in the last 5 years, or expect to have in the next 2 years, any financial interests (potential gains or losses) that could be affected by your submitted publication? Non-financial interests Do you have any of the following interests that could potentially influence or be affected by your submitted publication? No From employment or provision of services, such as directorships, consultancy, honoraria, etc. No Current and previous research findings or projects No From intellectual property, such as patents, copyrights, etc. No Commitments to specific standards or processes No From investments such as shares, stocks, other financial instruments, etc. No Publicly held positions or statements of public record No From litigation or legal cases No Personal relationships No From grants No Membership or active role in other organisations, e.g. societies, lobby or pressure groups, government agencies, etc. No Other financial interests No Position of authority in an organisation, such that you may be seen as upholding that organisation's views, standards, values, etc. No Other non-financial interests Please provide details about the financial interests you have indicated above Not applicable. Please provide details about the non-financial interests you have indicated above Not applicable 8 This form is distributed under a Creative Commons 4.0 BY licence Author information Name: Chris T. Evelo Date: 2025-09-17 Title of manuscript: ToxTempAssistant: Using Large Language Models to Standardise Cell-Based Toxicological Test Method Descriptions Contribution to the Publication Supervision, Funding acquisition, Writing - Review & Editing Interests Please select “Yes” or “No” next to any interests below that are relevant to your situation Financial interests Do you, your family, close relations or acquaintances, currently have, have had in the last 5 years, or expect to have in the next 2 years, any financial interests (potential gains or losses) that could be affected by your submitted publication? Non-financial interests Do you have any of the following interests that could potentially influence or be affected by your submitted publication? No From employment or provision of services, such as directorships, consultancy, honoraria, etc. No Current and previous research findings or projects No From intellectual property, such as patents, copyrights, etc. No Commitments to specific standards or processes No From investments such as shares, stocks, other financial instruments, etc. No Publicly held positions or statements of public record No From litigation or legal cases No Personal relationships No From grants No Membership or active role in other organisations, e.g. societies, lobby or pressure groups, government agencies, etc. No Other financial interests No Position of authority in an organisation, such that you may be seen as upholding that organisation's views, standards, values, etc. No Other non-financial interests Please provide details about the financial interests you have indicated above Not applicable. Please provide details about the non-financial interests you have indicated above Not applicable. 9