Indices of drinking water quality plan

Median DBP occurence Range of DBP occurence TOPSIS ranking b ToxPi ranking bRQ (IC50) RQ (IC20) RCR (%C1/2) RCR (%C1/10)pH BrNO3NO2Chloroform (CF) / trichloromethane (TCM) 9.16 0.0 – 575.9 Group 2B: Possible Human Carcinogen 7 3 0.006 (Low) 0.037 (Low) ~ ~ ↓ ↑ * Bromodichloromethane (BDCM) 3.67 0.0 – 201.7 Group 2B: Possible Human Carcinogen 34 15 ~↑↑ ↑ ↓ * Dibromochloromethane (DBCM) 1.1 0.0 – 77.3 Group 2B: Possible Human Carcinogen 23 12 ↑↑↑ ~ ~ * Bromoform (BF) / Tribromomethane (TBM) 0.35 0.0 – 930.7 Group 3: Not Classificable 20 9↑↑ ↑↑ ~ ~ * Bromochloroiodomethane (BCIM) N.D N.D. N.D. 17 8↑ ↑ ~ ~ Chloroacetic acid (CAA) 0.915 0.0 – 2454 N.D. 15 10 0.006 (Low) 0.014 (Low) 0.0003 (Acceptable) 0.0004 (Acceptable) ↑ ↓ ↓ ~* Dichloroacetic acid (DCAA) 7.915 0.0 – 6787.0 Group 2B: Possible Human Carcinogen 3 6 0.114 (Low) 0.161 (Medium) ↑↑↑ ↓ ↓ * Trichloroacetic acid (TCAA) 7 0.0 – 2564 Group 2B: Possible Human Carcinogen 31 32 ~↓ ↓ ~* Bromoacetic acid (BAA) 0.4 0.0 – 113.81 N.D. 14 21 ↓ ↑ ↑ ~* Dibromoacetic acid (DBAA) 1 0.0 – 1795 Group 2B: Possible Human Carcinogen 27 14 ↑↑↑ ↓ ↓ * 2,2-Dibromoacetonitrile (DBAN) 0.2 0.0 – 219.0 Group 2B: Possible Human Carcinogen 2 7 0.032 (Low) 0.10 (Medium) ↑↑↑ ↓~* Chloroacetonitrile (CAN) N.D N.D. Group 3: Not Classificable 26 22 ↓ ↓ ~ ~ 2,2,2-Trichloroacetonitrile (TCAN) 0.18 0.0 – 1.488 Group 3: Not Classificable 30 17 ↑ ↑ ↓ ~* 2,2-Dichloroacetonitrile (DCAN) 1.085 0.0 – 74.6 Group 3: Not Classificable 38 20 ↓ ↓ ↑↑ ↑* Tribromoacetonitrile (TBAN) N.D N.D. N.D. 40 55 ↓↑↑ ~ ~ Bromoacetonitrile (BAN) 0.6 N.D. N.D. 64 56 0.353 (Medium) 0.910 (Medium) N.D. N.D. ↓ ↑ ~ ~ Dichloroacetaldehyde (DCAL) 0.73 0.33 – 35.0 Group 2A: Probable Human Carcinogen 1 5 0.0 (Low) 0.003 (Low) 0.006 (Acceptable) 0.048 (Acceptable) ↑ ↓ ~ ~ Chloroacetaldehyde (CAL) N.D N.D. N.D. 5 4 ↑ ↓ ~ ~ Bromoacetaldehyde (BAL) N.D N.D. N.D. 8 13 ↑↑↑ ~ ~ Bromodichloroacetaldehyde (BDCAL) 1.2 0.0 – 46.0 N.D. 9 16 ↑ ↑ ~ ~ Dibromoacetaldehyde (DBAL) 1.5 0.7 – 2.5 N.D. 10 40 0.058 (Low) 0.153 (Medium) ↑↑↑ ~ ~ Bromochloroacetaldehyde (BCAL) 1.5 0.07 – 3.0 N.D. 12 43 ↑ ↓ ~ ~ Dibromochloroacetaldehyde (DBCAL) 0.4 0.0 – 1.75 N.D. 13 23 ↑↑↑ ~ ~ Tribromoacetaldehyde (TBAL) 0.33 0.0 – 30.89 N.D. 29 11 ↑↑↑ ~ ~ Iodoacetaldehyde (IAL) N.D N.D. N.D. 44 44 ↑~ ~ ~ Chloropicrin (CP) / Trichloronitromethane (TCNM) 0 0.0 – 54 N.D. 19 34 ↓~ ~ ↑↑ Bromochloronitromethane (BCNM) N.D N.D. N.D. 21 24 ↓↑↑ ~↑ Bromodichloronitromethane (BDCNM) N.D N.D. N.D. 22 25 ↓↑↑ ~↑ Dichloronitromethane (DCNM) N.D N.D. N.D. 25 19 ↓~ ~ ↑↑ Tribromonitromethane (TBNM) N.D N.D. N.D. 36 61 ↓↑↑ ~↑↑ 2,6-dibromo-4-chlorophenol (2,6-DBCP) 0.003 0.003 – 0.027 N.D. 39 69 ↑↑↑ ~ ~ 2,4,6-trichlorophenol (2,4,6-TCP) 0.001 0.0 – 0.032 Group 2B: Possible Human Carcinogen 28 41 ↑~ ~ ~ 2,4-dichlorophenol (2,4-DCP) 0.01 0.003 – 0.014 N.D. 32 62 ↑~ ~ ~ 4-iodophenol (4-IP) N.D N.D. N.D. 33 65 ↑~ ~ ~ 4-chlorophenol (4-CP) N.D N.D. N.D. 45 82 ↑~ ~ ~ 2-iodophenol (2-IP) N.D N.D. N.D. 48 51 ↑~ ~ ~ 2,4,6-triiodophenol (2,4,6-TIP) 0.001 0.001 – 0.022 N.D. 49 72 ↑~ ~ ~ Pentachlorophenol (PCP) N.D N.D. Group 1: Human Carcinogen 18 53 ↓↓ ~ ~ ~ 2-Chlorophenol (2-CP) 0.002 0.001 – 0.02 N.D. 24 45 ~ ~ ~ ~ 2-bromo-6-chloro-4-nitrophenol (2-B-6-CNP) N.D N.D. N.D. 43 64 ↑↑↑ ~↑ 2,6-diiodo-4-nitrophenol (2,6-DINP) 0.001 0.0 – 0.003 N.D. 37 66 ↓~ ~ ↑ 2,6-dibromo-4-nitrophenol (2,6-DBNP) 0.004 0.0 – 0.008 N.D. 50 78 ↑↑↑ ~↑ Acetaldehyde N.D N.D. Group 2B: Possible Human Carcinogen 47 29 ~ ~ ~ ~ Formaldehyde N.D N.D. Group 1: Human Carcinogen 4 2 ~ ~ ~ ~ Haloacetamides (HAcAms) Chloroiodoacetamide (CIAcAm) N.D N.D. N.D. 42 33 ↓~ ~ ↑ Halophenylacetonitriles (HPANs) 2-chlorophenylacetonitrile (2-CPAN) 0.015 0.005 – 0.155 N.D. 16 37 0.001 (Low) 0.001 (Low) N.D. 0.00001 (Acceptable) ↓~ ~ ~ Nitrosamines Nitrosodimethylamine (NDMA) 0.003 0.0 – 1.02 Group 2A: Probable Human Carcinogen 6 1 0.0 (Low) 0.0 (Low) ↑~ ~ ↑↑ NOTE: The amount of available data impacts the estimated rankings a. Median concentration and range taken from the DBPs occurrence database b. Considering various chemical properties, including: GHS and precautionary statements, hazard category, IARC, biodegradability, vapor pressure, occurrence probability, flash point and log(kow) c. Environmental risks level. Calculated from the IC50 and IC20 values from the luminescence assay (A. fischeri ) d. Human exposure risks level. Calculated from the %C1/2 and %C1/10 values from the resazurin assay (HEK 293 cells) e. Water quality parameters which modulate DBP formation. Here we assume that temperature and TOC ↑ DBP formation overall. * entries represent associations statistically validated in Deliverable 3.2 via PCA, CCA and MRA Halonitromethanes (HNMs) Halophenols (HPs) Halonitrophenols (HNPs) Aldehydes DBPs occurrence in drinking water (µg/L) a DBP formation water quality parameters drivers Risk characterization ratio (risk level) d Trihalomethanes (THMs) Haloacetic acids (HAAs) Haloacetonitriles (HANs) Haloacetaldehydes (HALs) DBP class (acronym) DBP (acronym) IARC Category MCDM rankings Risk quotient (risk level) c