Novel magnetoliposomes based on shape-anisotropic nanoparticles for combined chemotherapy and magnetic hyperthermia
Abstract
In this work, a new method for magnetoliposomes synthesis with improved and adequate structural, physicochemical and magnetic properties was developed. The overall results confirmed the development of a promising new method for the synthesis of cubic-shaped magnetic ferrite nanoparticles and a novel route for drug-loaded SMLs with improved features. The properties of these multifunctional nanosystems point to their future effective application in cancer therapy.
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Novel magnetoliposomes based on shape-anisotropic nanoparticles for combined chemotherapy and magnetic hyperthermia Beatriz D. Cardosoa, Ana R. O. Rodriguesa, Manuel Bañobre-Lópezb, Bernardo G. Almeidaa, Carlos O. Amorimc, Vítor S. Amaralc, Paulo J. G. Coutinhoa, Elisabete M. S. Castanheiraa a Centre of Physics (CFUM), University of Minho, Campus de Gualtar, 4710-057 Braga, Portugal b Advanced (magnetic) Theranostic Nanostructures Lab, Life Sciences Department, INL – International Iberian Nanotechnology Laboratory, 4715-330 Braga, Portugal c Physics Department and CICECO, University of Aveiro, Campus de Santiago, 3810-193 Aveiro, Portugal [email protected] Solid magnetoliposomes (SMLs) are multifunctional lipid nanocarriers urging as a promising therapeutic approach for cancer therapy. These nanocarriers allow the encapsulation of therapeutic drugs, improving their pharmacokinetics and associated pharmacodynamics while enabling their magnetic-controlled release. In this work, a new method for magnetoliposomes synthesis with improved and adequate structural, physicochemical and magnetic properties was developed. Shape-anisotropic cubic calcium-substituted magnesium ferrite nanoparticles (Ca 0.25 Mg 0.75 Fe 2 O 4 ) were synthesized and characterized, revealing high saturation magnetization (50.07 emu/g at 300 K) and heating abilities. The synthesized nanoparticles were covered with lipid bilayers of different compositions (DPPC, DPPC/Ch and DPPC/DSPE-PEG), originating SMLs with optimal sizes for in vivo applications (around or below 150 nm) and low polydispersity index. SMLs revealed high efficiencies of Doxorubicin encapsulation and to reduce its interaction with human serum albumin, highly contributing for a prolonged bioavailability of the drug upon systemic administration. The overall results confirmed the development of a promising new method for the synthesis of cubic-shaped magnetic ferrite nanoparticles and a novel route for drug-loaded SMLs with improved features. The properties of these multifunctional nanosystems point to their future effective application in cancer therapy.