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Magnetic Nanoparticles as MRI Contrast Agents

Avasthi, Ashish; Caro Salazar, Carlos; Pozo Torres, Esther; Pernia Leal, Manuel; García-Martín, María Luisa

Published
2020
Publisher
Springer
DOI
10.1007/s41061-020-00302-w
Repository
idus.us.es
Language
en

Abstract

Iron oxide nanoparticles (IONPs) have emerged as a promising alternative to conventional contrast agents (CAs) for magnetic resonance imaging (MRI). They have been extensively investigated as CAs due to their high biocompatibility and excellent magnetic properties. Furthermore, the ease of functionalization of their surfaces with different types of ligands (antibodies, peptides, sugars, etc.) opens up the possibility of carrying out molecular MRI. Thus, IONPs functionalized with epithelial growth factor receptor antibodies, short peptides, like RGD, or aptamers, among others, have been proposed for the diagnosis of various types of cancer, including breast, stomach, colon, kidney, liver or brain cancer. In addition to cancer diagnosis, different types of IONPs have been developed for other applications, such as the detection of brain inflammation or the early diagnosis of thrombosis. This review addresses key aspects in the development of IONPs for MRI applications, namely, synthesis of the inorganic core, functionalization processes to make IONPs biocompatible and also to target them to specific tissues or cells, and finally in vivo studies in animal models, with special emphasis on tumor models.

Full text

Vol.:(0123456789) Topics in Current Chemistry (2021) 379:30 https://doi.org/10.1007/s41061-021-00340-y 1 3 CORRECTION Correction to: Magnetic Nanoparticles asMRI Contrast Agents AshishAvasthi1· CarlosCaro1· EstherPozo‑Torres2· ManuelPerniaLeal2· MaríaLuisaGarcía‑Martín1,3 Published online: 14 June 2021 © The Author(s) 2021 Correction to: Topics in Current Chemistry (2020) 378:40 https:// doi. org/ 10. 1007/ s41061- 020- 00302-w The article Magnetic Nanoparticles as MRI Contrast Agents, written by Ashish Avasthi, Carlos Caro, Esther Pozo-Torres, Manuel Pernia Leal and María Luisa García-Martín was originally published Online First without open access. After publication in volume 378, issue 3, page 40, the Authors requested that the article be Open Choice to make the article an open access publication on May 20th. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third-party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https:// creat iveco mmons. org/ licen ses/ by/4. 0/. The original article can be found online at https:// doi. org/ 10. 1007/ s41061- 020- 00302-w. * Manuel Pernia Leal [email protected] * María Luisa García-Martín [email protected] 1 BIONAND - Centro Andaluz de Nanomedicina y Biotecnología, Junta de Andalucía- Universidad de Málaga, C/Severo Ochoa, 35, 29590Málaga, Spain 2 Departamento de Química Orgánica y Farmacéutica, Facultad de Farmacia, Universidad de Sevilla, 41012Seville, Spain 3 Networking Research Center onBioengineering, Biomaterials andNanomedicine, CIBER-BBN, Málaga, Spain Topics in Current Chemistry (2021) 379:30 1 3 30 Page 2 of 2 The original article has been corrected. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http:// creat iveco mmons. org/ licen ses/ by/4. 0/ Publisher’s Note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.