scieee Open visual document viewer

Impact of Charge Collection Efficiency and Electronic Noise on the Performance of Solid-state 3D Microdetectors

Prieto Pena, J.; Gómez, F.; Guardiola, C.; Jiménez Ramos, María del Carmen; García López, Francisco Javier; Baratto Roldán, A.; Baselga, M.; Pardo Montero, J.; Fleta, C.

Abstract

Microdosimetry has been traditionally performed through gaseous proportional counters, although in recent years different solid-state microdosimeters have been proposed and constructed for this task. In this paper, we analyze the response of solid-state devices of micrometric size with no intrinsic gain developed by CNM-CSIC (Spain). There are two major aspects of the operation of these devices that affect the reconstruction of the probability distributions and momenta of stochastic quantities related to microdosimetry. For micrometric volumes, the drift and diffusion of the charge carriers gives rise to a partial charge collection efficiency in the peripheral region of the depleted volume. This effect produces a perturbation of the reconstructed pulse height (i.e. imparted energy) distributions with respect to the actual microdosimetric distributions. The relevance of this deviation depends on the size, geometry and operating conditions of the device. On the other hand, the electronic noise from the single-event readout set-up poses a limit on the minimum detectable lineal energy when the microdosimeter size is reduced. This article addresses these issues to provide a framework on the physical constraints for the design and operation of solid-state microdosimeters.

Full text

Impac o cha ge collec ion e icency and elec onic noise on he pe o mance o solid s a e 3D-mic ode ec o s J P ie o-Pena1, F G´omez1,2, C Gua diola3,MC Jim´enez-Ramos4,5, J Ga c´ıa L´opez4,5, A Ba a o-Rold´an4,5, M Baselga6, J Pa do-Mon e o7and C Fle a8 1Depa amen o de F´ısica de Pa ´ıculas, Uni e sidade de San iago de Compos ela, 15782-San iago de Compos ela, Spain 2G upo de Imagen Molecula , Ins i u o de In es igaci´on Sani a ia, 15706-San iago de Compos ela, Spain 3Labo a oi e de Physique des 2 in inis I `ene Jolio -Cu ie (IJCLab-UMR9012) Uni e si ´e Pa is-Saclay, O say, 91405 F ance 4Cen o Nacional de Acele ado es, 41092 Se illa, Spain 5Depa men o A omic, Molecula and Nuclea Physics, Uni e sidad de Se illa, 41012 Se illa, Spain 6ETP (KIT), He mann- on-Helmhol z-Pla z 1, 76344 Eggens ein-Leopoldsha en, Ge many. Now a Deu sches Elek onen-Synch o on DESY, No kes asse 85, 22607 Hambu g, Ge many 7G upo de F´ısica M´edica e Bioma em´a icas, Ins i u o de In es igaci´on Sani a ia, San iago de Compos ela, 15706 Spain. 8Ins i u o de Mic oelec ´onica de Ba celona, Cen o Nacional de Mic oelec ´onica (IMB-CNM, CSIC), Bella e a 08193 Spain E-mail: [email p o ec ed] Abs ac . Mic odosime y has been adi ionally pe o med h ough gaseous p opo ional coun e s, al hough in ecen yea s di e en solid s a e mic odosime e s ha e been p oposed and cons uc ed o his ask. In his pape we analyze he esponse o solid s a e de ices o mic ome ic size wi h no in insic gain de eloped by CNM-CSIC (Spain). The e a e wo majo aspec s o he ope a ion o hese de ices ha a ec he econs uc ion o he p obabili y dis ibu ions and momen a o s ochas ic quan i ies ela ed o mic odosime y. Fo mic ome ic olumes he d i and di usion o he cha ge ca ie s gi es ise o a pa ial cha ge collec ion e iciency in he pe iphe al egion o he deple ed olume. Such e ec p oduce a pe u ba ion o he econs uc ed pulse heigh (i.e. impa ed ene gy) dis ibu ions wi h espec o he ac ual mic odosime ic dis ibu ions. The ele ance o his de ia ion depends on he size, geome y and ope a ion condi ions o he de ice. On he o he hand, he elec onic noise om he single e en eadou se -up poses a limi on he minimum de ec able lineal ene gy when he mic odosime e size is educed. This a icle add esses hese issues o p o ide a amewo k on he physical cons ain s o he design and ope a ion o solid s a e mic odosime e s. Impac o CCE and noise on silicon-based 3D-mic ode ec o s 2 1. In oduc ion High ene gy p o on and hea ie ion ex e nal beam he apy p esen s ce ain adiobiological and physical p ope ies ha allows be e esul s han con en ional pho on and elec on ex e nal adio he apy in se e al ypes o cance . Pa icle he apy is capable o inducing mo e damage o he umo issue a cellula and sub-cellula le els compa ed o pho on he apy o compa able mac oscopic dose le els and a be e dose con o ma ion o he a ge olume (Du an e & Loe le 2010). The a ionale behind his beha io is ha p o ons and ions can ha e a much highe Linea Ene gy T ans e (LET) han ha p oduced by cha ged pa icles p esen in con en ional pho on and elec on he apy, and his highe concen a ion o ene gy deposi ion leads o mul iple clus e ed single-s and and double-s and b eaks o cellula DNA. This amoun o damage p o okes a highe numbe o cell inac i a ion and apop osis han wi h pho on beams, since ha damage is mo e di icul o epai (B enne & Wa d 1992). The inc eased numbe o acili ies capable o p o iding hese ypes o ea men has been inc easing in he las yea s all a ound he wo ld (Dosanjh, Amaldi, Maye , Poe e e al. 2018, Pa icle The apy Co-Ope a i e G oup 2019). In pa icle he apy he dose is e alua ed in e ms o pho on isoe ec i e dose, which is calcula ed as he p oduc o he physical dose (abso bed dose o wa e ) and he ela i e biological e ec i eness o RBE (IAEA 2008). RBE is dependen on physical and biological ac o s, such as LET and se e al o he biological p ocesses ha di e as a unc ion o he a ge issue (B i en, Pe e s & Mu ay 2001, Pagane i 2014). The B agg peak, o he s opping ange o he ions, coincides wi h he egion o maximum RBE. To cha ac e ize he pho on isoe ec i e dose, i is impo an o know he ene gy deposi ion along he pa icle acks a sub-mic ome ic le els (K ¨ame & Scholz 2000). As he adi ional dosime ic quan i ies used in pho on and elec on ex e nal adio he apy a e based on a e age alues o deposi ed ene gy in la ge egions and in ol ing a la ge numbe o e en s, hey canno be used o he small scales needed in pa icle he apy. A mic oscopic scales, he s ochas ic na u e o he adia ion-ma e in e ac ions equi es quan i ies based on dis ibu ion p obabili ies ins ead o me ics based on expec a ion alues. The ole o mic odosime y is o p o ide he ull desc ip ion o hese quan i ies. Fo mic odosime y applica ions, issue equi alen gaseous p opo ional chambe s (TEPC) a e he mos commonly used de ec o s. Thei p inciple o ope a ion is based on he use o a gas a a e y low p essu e wi h he same mass s opping powe ha a ce ain olume o issue equi alen solid issue, allowing o simula e a issue equi alen mic oscopic si e h ough he use o a gaseous mac oscopic si e. The main disad an age o hese de ec o s is ha wall-e ec s can cause dis o ions in hei eading. These e ec s can be a oided by using an i e a ion o he TEPC de ec o s called wall-less TEPC. Rega dless, any model o TEPC will ha e millime ic spa ial esolu ion due o i s mac oscopic size and show pile-up e ec s unde beams o high luence a e (as in Impac o CCE and noise on silicon-based 3D-mic ode ec o s 3 clinical beams, wi h luence a es g ea e han 108pa icles s−1cm−2). They a e di icul o ope a e due o he use o high ol ages, gas supply equi emen s and hei size makes mo ing hem a ea on i s own. All hese ac s make hem un easible o daily po en ial quali y assu ance and limi he p ac ical use o hese de ices in clinical ix u es. Despi e all hese d awbacks, he TEPC echnology has been he s anda d o mic odosime ic measu emen s up o now, and ecen ly, new e sions o hese de ec o s ha e been in oduced, such as he mini-TEPC, which can imp o e mos o he pe o mance limi a ions associa ed wi h hei size. (Colau i, Con e, Sel a, Chi io i, Pola, Bo o , Fazzi, Agos eo & Ciocca 2017, Fa ahmand, Bos, De Na do & Van Eijk 2004, De Na do, Cesa i, Don`a, Mag in, Colau i, Con e & To nielli 2004, Kliauga 1990). Solid s a e adia ion de ec o s a e commonly used o pe o m he dosime ic cha ac e iza ion o adia ion ields, and p esen ad an ages such as as esponse and good ene gy esolu ion. This amily o de ec o s, ha ing a highe mass densi y in he ac i e olume han a gas-based de ec o , can be manu ac u ed down o mic ome ic and submic ome ic dimensions, and hus close o he ac ual cell o cellula s uc u e sizes o in e es , allowing i s use o mic odosime y applica ions. No only can solid-s a e de ec o s ha e high ene gy esolu ion, as signal p ocessing and a small size, bu hey a oid some o he disad an ages o he TEPC, as hey do no need high ol age bias and exhibi an o e all easie de ice ope a ion. The use o h ee-dimensional a chi ec u e was p oposed o silicon de ec o s (Pa ke , Kenney & Segal 1997) in he ields o medical imaging and pa icle acking in high ene gy physics (Pelleg ini, Lozano, Ullan, Ba es, Fle a & Pennica d 2008). This con igu a ion would be able o educe he loss o cha ge ca ie s due o apping e ec and sho en he cha ge collec ion ime compa ed o adi ional plana solid-s a e de ec o s. In he 3D con igu a ion, he ol age equi ed o p o oke ull deple ion in he bulk is also educed, and o hin de ices o up o 50 µm hickness he capaci ance o a 3D mic o-s uc u ed solid-s a e de ec o is a leas wo o de s o magni ude lowe han o adi ional plana de ec o s (Pelleg ini, Ga cia, Balbuena, Cab uja, Lozano, O a a & Ullan 2009). The signal o noise a io (SNR) is imp o ed since SNR is in e sely p opo ional o he capaci ance (Spiele 2005). Ne e heless, solid s a e de ices also ha e some p oblems o hei own ha limi hei use ulness in dosime y. In he case o silicon, i s non equi alence o issue bo h in mass ene gy abso p ion coe icien and s opping powe coe icien makes i necessa y o apply co ec ion ac o s in o de o ob ain he mic odosime ic dis ibu ions in wa e . I is impo an ha he ype o de ices desc ibed in his a icle a e aligned wi h i s sensi i e olume pe pendicula o he p opaga ion di ec ion o he beam, as a misalignmen can p oduce a di e en mean cho d leng h o he beam pa icles, a ec ing he econs uc ed lineal ene gy spec a (Bols , Gua elli, T an & Rosen eld 2018). Also, silicon de ices a e suscep ible o adia ion damage which deg ades hei pe o mance wi h o al dose. Addi ionally, he e can be a loss o collec ed cha ge p oduced om he ack ioniza ion due o ecombina ion ha a ec s he econs uc ion o he impa ed ene gy dis ibu ions, hus modi ying he mic odosime ic spec a. This e ec is summa ized Impac o CCE and noise on silicon-based 3D-mic ode ec o s 4 usually h ough he cha ge collec ion e iciency dependence on he ack impac posi ion. E en hough new de elopmen s in low-gain a alanche diodes (LGAD) use in insic ampli ica ion o enhance SNR (Pelleg ini, Fe n´andez-Ma ´ınez, Baselga, Fle a, Flo es, G eco, Hidalgo, Mandi´c, K ambe ge , Qui ion e al. 2014), his ampli ica ion is s ill limi ed and he lack o in insic ampli ica ion in cu en 3D silicon de ec o echnology comp omises he signal o noise a io o de ices in he mic ome e and sub-mic ome e dimensions. In his pape he ac i e olume and cha ge collec ion p ope ies o a cylind ical silicon mic odosime e de eloped by IMB-CNM (CSIC, Spain) was s udied. In he case o he de ice employed o his wo k, he ou pu signal is conside ed p opo ional o he impa ed ene gy in he sensi i e olume. F om he spec a gi en by he de ec o signal, o he mic odosime ic quan i ies can be calcula ed. To e alua e he cha ge collec ion p ope ies o he de ice, a model o cha ge collec ion e iciency as a unc ion o he dis ance o he cen e o he ac i e a ea was de eloped and hen compa ed wi h expe imen al da a om es uns conduc ed a he synch o on o he Fondazione CNAO (Pa ia, I aly) using a ca bon ion beam and a CNA (Se ille, Spain) using a p o on mic obeam. Addi ionally, he de ec ion limi o 3D mic os uc u ed de ec o s as a unc ion o hei size is s udied by means o a simple model ha akes in o accoun elec onic noise om he eadou elec onics. 2. Ma e ials and me hods 2.1. Silicon mic odosime e The mic odosime e employed in his wo k is a new ype o h ee dimensional diode designed and de eloped by IMB-CNM (CSIC) a hei acili ies in Ba celona, Spain (Gua diola, Qui ion, Pelleg ini, Fle a, Es eban, Co ´es-Gi aldo, G´omez, Solbe g, Ca abe & Lozano 2015). The de ec o is comp ised o se e al indi idual senso s o uni cells a anged in an a ay capable o indi idual eadou o he de ec ion o ene gy deposi ion e en s. These cells ha e a h ee-dimensional cylind ical s uc u e e ched inside he silicon bulk wi h an implan ed p+ cha ge collec ing elec ode su ounded by a concen ic n+ elec ode ench. The cylind ical cell axis is pe pendicula o he silicon wa e plane. A scanning elec on mic oscope image and a schema ic c oss sec ion o he de ice can be seen in igu e 1. Al hough he ab ica ion p ocess allows he p oduc ion o de ec o s wi h di e en diame e o he cylind ical senso s, in he de ice employed in his wo k we ha e se he he physical size o he silicon cylinde as 20 µm in diame e bu due o he elec ic ield dis ibu ion o he de ice he sensi i e size o he cylinde is 15 µm in diame e . In his way he size and shape o he silicon sensi i e olume is simila o hose o mammalian cell (Ginzbe g, Ka i & Ki schne 2015). The diame e o he cen al implan ed elec ode is 4 µm and he wid h o he n+ ench is 3 µm. The senso s in he silicon die a e a anged in a squa e ma ix wi h p-elec ode Impac o CCE and noise on silicon-based 3D-mic ode ec o s 5 Figu e 1. C oss sec ion schema ic o he de ec o (no o scale, le ) along wi h an elec on mic oscope image o he 3D-mic ode ec o op- iew ( igh ). indi idual eadou . The pi ch be ween wo consecu i e de ec o cen e s in his pa icula de ice is 200 µm al hough his can also be a ied i desi ed. All he n-elec odes a e connec ed o he same pad on he opposi e side o he a ay o bias connec ion. In his wo k, only he eadou om one indi idual cell a a ime was ully ins umen ed, keeping he es o he senso s g ounded. The hickness o he sensi i e olume is 5.5±0.5 µm. The ene gy esolu ion was es ima ed om measu emen s as 12% ull-wid h a hal - maximum (FWHM) a 660 keV. Mo e in o ma ion abou he ab ica ion p ocess and Technological Compu ed Assis Design (TCAD) simula ions o he deple ion olume and cha ge collec ion can be ound a (Fle a, Es eban, Baselga, Qui ion, Pelleg ini, Gua diola, Co ´es-Gi aldo, L´opez, Ramos, G´omez e al. 2015). These de ec o s a e designed o pe o m mic odosime ic measu emen a nominal luence a e in had on he apy, allowing an ins umen al e i ica ion o he lineal ene gy spec a a di e en dep h and posi ions in a phan om (G´omez, Fle a, Es eban, Qui ion, Pelleg ini, Lozano, P ezado, Dos San os, Gua diola, Mon a ou e al. 2016, P ie o-Pena, G´omez, Fle a, Gua diola, Pelleg ini, Done i, Gio danengo, Gonz´alez-Cas a˜no & Pa do- Mon e o 2019). Thei design p oduces a high con o ma ion o he deple ed egion o a olume o app oxima ely 900 µm3. The in insic ield g adien s p esen in he de ice oge he wi h he cha ge d i and di usion p o oke ha in he mic odosime e cell pe iphe y he cha ge collec ion e iciency exhibi s a ela i ely as decay o ze o alues. Pa ially deple ed silicon olumes p esen in he de ice lead o ecombina ion o he ioniza ion cha ge and pa ial cha ge collec ion. Due o he in insic echnological limi s in he mic oelec onics manu ac u ing p ocesses, his cha ge collec ion ansi ion is no negligible in gene al e ms and can a ec he econs uc ed mic odosime ic spec um om he silicon mic o-cell. This issue has been add essed in he p esen s udy o e alua e i s signi icance and he limi a ion i poses o ac ual mic odosime e geome ies. All he esul s p esen ed in his wo k a e shown in e ms o ene gy deposi ion in silicon. Howe e , he silicon ene gy deposi ion spec a can be con e ed o issue equi alen ma e ial by a look up able me hodology like ha used in (P ie o-Pena e al. 2019). Impac o CCE and noise on silicon-based 3D-mic ode ec o s 6 2.2. Elec ical simula ions Elec ical simula ions we e conduc ed wi h a TCAD so wa e, Sen au us Synopsys. This so wa e sol es he Poisson equa ion o he s udied geome y. TCAD simula ions gi e a de ailed desc ip ion o he elec ical ield o he mic odosime e as well as he ansien o a hea y ion h ough any angle o he de ice, gi ing he cha ge collec ion. The simula ed de ice is a 20 µm diame e n- ype (wi h a doping concen a ion o 8.61 ×1011 cm−3) mic odosime e . The silicon wa e s which he silicon de ec o s a e ab ica ed om ha e a hickness o 5.5 ±0.5 µm, wi h he hickness o his de ec o sample de e mined o be 5.3 µm. The silicon dioxide cha ge su ace densi y used is 1011 cm−2. The elec ical simula ions we e ca ied ou wi h 0 V, 5 V and 10 V bias ol age. Expe imen al measu emen s wi h 5 MeV alpha pa icles indica e a ull deple ion o he mic odosime e sensi i e olume a a 5 V bias ol age (Fle a e al. 2015). The ansien simula ions use he He yIon so wa e unc ion, wi h pa icles ha ha e an LET in silicon (Linea Ene gy T ans e unc ion) o 1.282 10−5pC/µm impinging pe pendicula ly o he su ace o he mic odosime e . 2.3. Expe imen al se -up The cha ac e iza ion o hese de ices wi h ion he apy beams we e pe o med using a 115.25 MeV A−1 12C ion beam a Fondazione CNAO (Pa ia, I aly). This synch o on acili y has an ac i e scanning p o on and ca bon ion beam. Du ing he measu emen s we used he signal om a mono-ene ge ic pencil beam c ossing 20 cm o ai be ween he nozzle exi and he measu ing ins umen . Se e al measu emen s we e ca ied ou placing he mic odosime e behind a a iable dep h o polyme hyl me hac yla e (PMMA, densi y 1.186 g cm−3). The dep h was con olled using a mo o ized emo e wedge sys em. The wedge sys em is o med by wo 10◦PMMA wedges allowing a a iable dep h o 3 mm o 40 mm wi h an unce ain y o he dep h o app oxima ely 30 µm. PMMA is a issue-equi alen ma e ial, allowing o pe o m measu emen s in he ields o mic odosime y and adiobiology, he main scope o hese de ec o s. The se o mic odosime ic spec a ob ained co e om he beam en ance pla eau up o he B agg peak o he ion beam used. The mic odosime e was connec ed o a CAEN A1422H Hyb id cha ge sensi i e p eampli ie and o a CAEN N968 spec oscopy shaping ampli ie . Then, he esul ing pulse heigh was digi ized h ough an Amp ek MCA8000D mul ichannel analyze placed in he expe imen al oom, connec ed ia E he ne o a compu e in he con ol oom whe e he spec a we e s o ed. The p e ious wo k done using he CNAO clinical beam 12C ion beam o CNAO wi h he cylind ical mic odosime e s (P ie o-Pena e al. 2019) exhibi a easonable ag eemen wi h he Mon e Ca lo simula ions. Ne e heless, expe imen al pulse heigh dis ibu ions (using any bias ol age in he ange o 0-20 V) always show a ele an ail wi h high numbe o coun s in he low-ene gy pa o he spec a and a small shi when compa ed wi h espec o he peak posi ion in he simula ed impa ed ene gy dis ibu ions, as can Impac o CCE and noise on silicon-based 3D-mic ode ec o s 7 Figu e 2. Expe imen al spec um (blue do ed line) measu ed wi h he IMB 3D mic ode ec o and FLUKA Mon e Ca lo simula ion ( ed solid line) o 115.25 MeV A−1 12C ions a e sing 25.20 mm o PMMA (P ie o-Pena e al. 2019). be seen in igu e 2, aken wi h no bias ol age. Elec onic noise con ibu ions, ampli ie baseline shi s o pile-up e en s ha e no been ound o be able o gene a e his dis o ion o he measu ed da a om he mic odosime e s. The e ec o spec ome y dis o ion in silicon mic osenso s has been epo ed p e iously in di e en de ices wi h high g anula i y eadou (Gimenez, Ballab iga, Campbell, Ho swell, Llopa , Ma chal, Sawhney, Ta oni & Tu ecek 2011, Campbell, Heijne, Hol´y, Id´a aga, Jakubek, Lebel, Le oy, Llopa , Posp´ısil, Tlus os & Vykydal 2008). I is hypo hesized ha his beha io is p oduced by in insic ield g adien s and cha ge di usion ha modi y he eco ded spec a by he mic osenso , p o oking pa ially deple ed olumes leading o ecombina ion and pa ial cha ge collec ion in he pe iphe y o he mic ocylinde . 2.4. Mon e Ca lo simula ions The expe imen al wo k was benchma ked agains a Mon e Ca lo simula ion o he beam ene gy deposi ion in an indi idual cell o he de ec o . Mon e Ca lo simula ions we e pe o med using he FLUKA Mon e Ca lo code (Fe a i, Sala, Fasso Impac o CCE and noise on silicon-based 3D-mic ode ec o s 8 Figu e 3. Pulse heigh spec um o 600 keV p o on beam in acuum aken a he IBIC beam a CNA (Se ille, Spain). & Ran 2005, B¨ohlen, Ce u i, Chin, Fass`o, Fe a i, O ega, Mai ani, Sala, Smi no & Vlachoudis 2014), de eloped by CERN and INFN. The e is a p ede ined con igu a ion in he code o i s use in had on he apy (”HADROTHE apy”) ha was selec ed o he simula ions, changing he de aul h esholds o he anspo o all pa icles, mul iple sca e ing and del a ay p oduc ion and co ec ions o o m ac o o Comp on Sca e ing. A s ic e addi ional limi o he kine ic ene gy h eshold was selec ed, changing i o 1 keV. This op ion was selec ed o ep oduce he expe imen al esul s mo e accu a ely wi hou adding oo much addi ional compu a ion ime, as de ailed in (B¨ohlen, Ce u i, Dosanjh, Fe a i, Gudowska, Mai ani & Quesada 2010). Fo each geome y a simula ion wi h 105his o ies was compu ed. The es ima ed ela i e s a is ical unce ain y o he simula ion in he pla eau egion o he B agg cu e is less han 2%. The code was commissioned agains a wa e dep h dose dis ibu ion o he same CNAO expe imen al beam measu ed wi h a Peak inde a iable wa e column and a PTW 34080 B agg-peak chambe , simila o a p ocedu e desc ibed elsewhe e (G´omez e al. 2016). The simula ion esembles he pencil beam’s main cha ac e is ics, such as ene gy and angula sp ead a he exi window o he gan y oge he wi h Impac o CCE and noise on silicon-based 3D-mic ode ec o s 9 he anspo ac oss he PMMA wedge and myla window and o he ma e ials o he de ec o me allic case and silicon suppo . 2.5. Cha ge Collec ion E iciency model The econs uc ed impa ed ene gy in he de ec o ac i e olume is ob ained om he pulse heigh dis ibu ion o he senso . Each e en pulse heigh is he e conside ed as he con olu ion o he ac ual ene gy deposi ion along he silicon de ec o wi h he e ec i e cha ge collec ion e iciency map. Fo he de ailed e alua ion o he Cha ge Collec ion E iciency (CCE) we used he Ion Beam Induced Cha ge (IBIC) echnique p o on mic obeam acili y a CNA (Se ille). Du ing he i adia ion he beam was scanned h ough he de ec o and he eadou was pe o med h ough a synch onized ampli ie and digi ize chain. The kine ic ene gy o he p o on beam employed was 600 keV in di e en es uns conduc ed in acuum. Figu e 3 shows he pulse heigh spec a o 0 V and 3 V bias ol age in he IBIC p o on beam. A phenomenological model o he CCE was de eloped o desc ibe he expe imen al esul s and Mon e Ca lo simula ions. He e, no only he impa ed ene gy was eco ded, bu also he posi ion and di ec o cosines o he ajec o y o he pa icles when hey en e in o he de ec o olume. Ioniza ion was gene a ed in a 0.05 µm s ep oxel geome y, acco ding o FLUKA dis ibu ions, along he s aigh line a e sing he de ec o olume wi h an angle equal o he cosines o he pa icle. I was conside ed ha o he pa icles and ene gy used he la e al s aggling was negligible when compa ed wi h he dimensions o he de ec o (Be ge , Cou sey, Zucke , Chang e al. 1998). Once he ioniza ion cloud along he ack is p oduced, each cha ge oxel is weigh ed wi h he poin dependen model CCE unc ion, and hen all he weigh ed cha ge con ibu ions a e e en ually added o ob ain he expec ed signal o each e en . The CCE unc ion cons uc ed is based on exponen ial unc ions wi h dependence on bo h he dis ance o he cen al axis o he cylinde ( ) and he dep h a e sed by he pa icle (h). Radial and e ical dependence a e sepa a ed in he model. A six-pa ame e unc ion was cons uc ed as shown in he ollowing equa ion: F( , h) = ( )⊗g(h) (1) ( ) = 1 + e−g 1 1−e−g 21−eg ( − 2) 1 + eg ( − 1)(2) g(h) = 1 + e−ghh1 1−e−ghh21−egh(h−h2) 1 + egh(h−h1)(3) whe e and ha e he alues o he adius and heigh ( om he geome ical cen e o he cylinde ), 1and h1a e he poin s in which he CCE unc ion eaches a alue o 0.5, 2and h2a e he poin s in which he unc ion goes o ze o, and g and gza e he g adien s o he exponen ial decay. Addi ionally, he e ical h componen has a ha d limi in h=2.75 µm due o he de ec o dimensions ( hickness o 5.5 µm). Impac o CCE and noise on silicon-based 3D-mic ode ec o s 16 Mos p obable lineal ene gy, ymp (keV µm-1) 0 50 100 150 200 250 300 350 400 Peak posi ion di e ence (keV µm-1) 0 2 4 6 8 10 12 14 16 18 Figu e 10. Peak shi in keV/µm o all measu ed poin s wi h he cylind ical mic osenso along he B agg cu e as a unc ion o he mos p obable lineal ene gy, ymp. de ec o leakage cu en and α,β,γ,δand κa e noise pa ame e s associa ed o he elec onic eadou chain due o shun and se ies esis ance, senso bias cu en and ampli ie con ibu ions (Radeka 1974, Be uccio & Pullia 1993). Fo his wo k, we ha e conside ed sizes Lo cylind ical mic ode ec o s om 0.1 µm up o 40 µm wi h Cin anging om 0.01 pF up o 5.3 pF and Id om 1 pA up o 950 pA. These alues we e aken acco ding o ou expe ience wi h simila de ices. We used pa ame e s om he s a e o he a elec onics (CR-110 e e ence shee n.d.) o calcula e ha ENC would yield alues be ween 260 up o 290 elec ons o a shaping ime o 1 µs espec i ely (α= 43 pF−2µse2;β= 15 pF; γ= 8 µs−1pA−1e2;δ= 800 pA; κ= 5 ×104 e2). We ha e conside ed wo scena ios, namely: when he ack incidence is o be pa allel o he cylinde axis conside ed abo e, hus ha ing < l >=L(denomina ed axial) and when he e is µ- andomness wi h < l >=2 3L(denomina ed iso opic). Fo he noise sepa a ion we ha e assumed ha he FWHM equi alen noise ene gy would be 2.35 imes he ENC mul iplied by he a e age ene gy wpe ion-elec on pai , hus p o iding a h eshold on he ene gy impa ed de ec ion aken as wo imes his FWHM (Radeka 1974)  h ≥2×ENC ×2.35 ×W Impac o CCE and noise on silicon-based 3D-mic ode ec o s 17 0 5 10 15 20 25 30 35 40 0 1 2 3 4 5 6 7 8 9 10 Size o mic odosime e (µm) Limi o lineal ene gy de ec ion (keV/µm) Silicon iso opic Diamond iso opic Silicon axial Diamond axial Figu e 11. Limi o de ec abili y o lineal ene gy in cylind ical mic o–dosime e s wi h equal diame e and heigh Las a unc ion o L. Do ed and con inuous lines co espond o diamond and silicon de ec o s unde iso opic condi ions espec i ely. Dashed and do -dashed lines co espond o diamond and silicon de ec o s o axial incidence espec i ely. This p o ides also a co esponding limi on he lineal ene gy de ec ion in he o m o y h = h < l > ≥4.7×ENC ×W < l > Thus we can e alua e he co esponding limi s o he de ec ion o he lineal ene gy conside ing hese cylind ical mic ode ec o s o di e en size L. Figu e 11 shows he limi s on he de ec ion o lineal ene gy in he de ec ing ma e ial as a unc ion o he de ec o size bo h o iso opic and pa allel o he cylinde axis incidences. In his Figu e we ha e included bo h diamond and silicon senso s jus o guide he eade in e ms o he physical limi s expec ed om he di e en cha ac e is ics o he sensi i e media. In he axial incidence scena io, he capabili y o ex end he de ec ion ange o 1 keV/µm would be achie ed in silicon when he size o he mic osenso is equal o bigge han 4.4 µm while in he case o diamond his would imply a senso o 16 µm hickness. Addi ionally, i is clea ha sub-mic on mic odosime e s would be only use ul o highly ionizing pa icles, since o silicon (diamond) de ices o 1 µm we would only be able o de ec adia ion wi h lineal ene gy o e 4.5 keV/µm (15.7 keV/µm). This conclusion Impac o CCE and noise on silicon-based 3D-mic ode ec o s 18 ends o exclude he easibili y o solid s a e mic odosime e s as adequa e de ices o ack s uc u e measu emen in he egion a ound 0.1 µm o below, a leas o non in insic gain senso s. Those limi s a e e en la ge o he iso opic condi ions whe e, o example, o achie e a de ec ion limi below 1 keV/µm i would be needed a senso o 6.7 µm size in silicon while o diamond his limi yields a alue o 25 µm. In ac he use o de ices o en hs o mic ons would yield alues close o he Linea Ene gy T ans e han he s ochas ic lineal ene gy conside ed in mic odosime ic dis ibu ions. O cou se, he esul s o his sec ion could be ecalcula ed conside ing he pa icula elec onic noise, senso cha ac e is ics and eadou unde s udy. 4. Conclusions Solid-s a e de ices can be employed o measu e mic odosime ic spec a. Cha ge collec ion e iciency (CCE) and elec onic noise pose limi a ions on hei pe o mance since hey can a ec he ideli y o he mic odosime ic dis ibu ions and he h esholds o lineal ene gy de ec ion. Fo he cylind ical de ice s udied in his wo k wi h 15 µm diame e and 5.5 µm hickness, he in insic ield g adien s and cha ge di usion in he sensi i e olume o he de ec o modi y he eco ded spec a by inducing a cha ge collec ion e iciency s ongly dependen on he posi ion o he ene gy deposi ion e en . These pe u ba ions modi y he aw expe imen al mic odosime ic spec a in a sys ema ic way, p oducing an a i icial enhancemen o he low lineal ene gy egion. In he p esen wo k his e idence was ound in 12C beam measu emen s a CNAO. In o de o ep oduce his sys ema ic e ec we cons uc ed a i s phenomenological model o he CCE by using an exponen ial unc ion and six pa ame e s ela ed o he physical dimensions o he mic os uc u ed de ec o . Elec ical simula ions using TCAD a di e en biasing ol ages and p o on beam IBIC es s pe o med o s udy he ac i e olume inside he mic odosime e s we e addi ionally used o alida e he CCE model. Mon e Ca lo simula ions we e modi ied by using his model o compu e he pa ial cha ge collec ion in he simula ed ene gy deposi ion e en s. Recons uc ed spec a including CCE e ec showed conside able ag eemen wi h he expe imen al esul s. The mos p obable lineal ene gy in hese expe imen al spec a is shi ed wi h espec o he expec a ion alue ob ained wi h Mon e Ca lo simula ions. This shi along he B agg cu e holds a linea ela ionship wi h he lineal ene gy. Addi ionally o he dis o ion o he low lineal ene gy spec a, he elec onic noise con ibu ion se s a heo e ical limi on he smalles de ec able lineal ene gy o mic os uc u ed solid s a e de ices. Conside ing a cylind ical de ice wi h equal diame e and heigh L, he lineal ene gy h eshold would be in e sely p opo ional o his pa ame e . Fo example, o de ec ing e en s o 1 keV/µm, he dimension Lshould be g ea e han 4.4µm whe eas in diamond his size should be a leas 16 µm. Impac o CCE and noise on silicon-based 3D-mic ode ec o s 19 Acknowledgmen s C Gua diola has ecei ed unding om he Eu opean Union’s Ho izon 2020 esea ch and inno a ion p og am unde he Ma ie Sklodowska-Cu ie g an ag eemen No 745109. M C Jim´enez-Ramos acknowledge suppo om he Spanish p ojec RTI2018-098117-B- C21 unded by Minis y o Science, Inno a ion and Uni e si ies. Re e ences Be ge , M. J., Cou sey, J., Zucke , M., Chang, J. e al. (1998). S opping-powe and ange ables o elec ons, p o ons, and helium ions, NIST Physics Labo a o y Gai he sbu g, MD. Be uccio, G. & Pullia, A. (1993). A me hod o he de e mina ion o he noise pa ame e s in p eampli ying sys ems o semiconduc o adia ion de ec o s, Re iew o Scien i ic Ins umen s 64(11): 3294–3298. B¨ohlen, T., Ce u i, F., Chin, M., Fass`o, A., Fe a i, A., O ega, P., Mai ani, A., Sala, P. R., Smi no , G. & Vlachoudis, V. (2014). The luka code: de elopmen s and challenges o high ene gy and medical applica ions, Nuclea da a shee s 120: 211–214. B¨ohlen, T. T., Ce u i, F., Dosanjh, M., Fe a i, A., Gudowska, I., Mai ani, A. & Quesada, J. (2010). Benchma king nuclea models o luka and gean 4 o ca bon ion he apy, Physics in Medicine & Biology 55(19): 5833–5847. Bols , D., Gua elli, S., T an, L. T. & Rosen eld, A. B. (2018). Op imisa ion o he design o soi mic odosime e s o had on he apy quali y assu ance, Physics in Medicine & Biology 63(21): 215007. B adley, P. D. & Rosen eld, A. B. (2015). Tissue equi alence co ec ion o silicon mic odosime y de ec o s in bo on neu on cap u e he apy, Medical Physics 25(11): 2220–2225. B enne , D. & Wa d, J. (1992). Cons ain s on ene gy deposi ion and a ge size o mul iply damaged si es associa ed wi h dna double-s and b eaks, In e na ional jou nal o adia ion biology 61(6): 737–748. B i en, R. A., Pe e s, L. J. & Mu ay, D. (2001). Biological ac o s in luencing he be o neu ons: implica ions o hei pas , p esen and u u e use in adio he apy, Radia ion esea ch 156(2): 125–135. Campbell, M., Heijne, E., Hol´y, T., Id´a aga, J., Jakubek, J., Lebel, C., Le oy, C., Llopa , X., Posp´ısil, S., Tlus os, L. & Vykydal, Z. (2008). S udy o he cha ge sha ing in a silicon pixel de ec o by means o α-pa icles in e ac ing wi h a Medipix2 de ice, Nuclea Ins umen s and Me hods in Physics Resea ch Sec ion A: Accele a o s, Spec ome e s, De ec o s and Associa ed Equipmen 591(1): 38 – 41. Radia ion Imaging De ec o s 2007. Colau i, P., Con e, V., Sel a, A., Chi io i, S., Pola, A., Bo o , D., Fazzi, A., Agos eo, S. & Ciocca, M. (2017). Mic odosime ic s udy a he cnao ac i e-scanning ca bon-ion beam, Radia ion p o ec ion dosime y 180(1-4): 157–161. CR-110 e e ence shee (n.d.). Accessed: 2019-06-03. De Na do, L., Cesa i, V., Don`a, G., Mag in, G., Colau i, P., Con e, V. & To nielli, G. (2004). Mini- epcs o adia ion he apy, Radia ion p o ec ion dosime y 108(4): 345–352. Dosanjh, M., Amaldi, U., Maye , R., Poe e , R. e al. (2018). Enligh : Eu opean ne wo k o ligh ion had on he apy, Radio he apy and Oncology 128(1): 76–82. Du an e, M. & Loe le , J. S. (2010). Cha ged pa icles in adia ion oncology, Na u e e iews Clinical oncology 7(1): 37–43. Fa ahmand, M., Bos, A., De Na do, L. & Van Eijk, C. (2004). Fi s mic odosime ic measu emen s wi h a epc based on a gem, Radia ion p o ec ion dosime y 110(1-4): 839–843. Fe a i, A., Sala, P., Fasso, A. & Ran , J. (2005). ” luka: a mul i-pa icle anspo code”, ce n 2005-10 (2005), Technical epo , INFN/TC 05/11, SLAC. Impac o CCE and noise on silicon-based 3D-mic ode ec o s 20 Fle a, C., Es eban, S., Baselga, M., Qui ion, D., Pelleg ini, G., Gua diola, C., Co ´es-Gi aldo, M., L´opez, J. G., Ramos, M. J., G´omez, F. e al. (2015). 3d cylind ical silicon mic odosime e s: ab ica ion, simula ion and cha ge collec ion s udy, Jou nal o Ins umen a ion 10(10): P10001. Gimenez, E. N., Ballab iga, R., Campbell, M., Ho swell, I., Llopa , X., Ma chal, J., Sawhney, K. J. S., Ta oni, N. & Tu ecek, D. (2011). S udy o cha ge-sha ing in MEDIPIX3 using a mic o- ocused synch o on beam, Jou nal o Ins umen a ion 6(01): C01031–C01031. Ginzbe g, M. B., Ka i, R. & Ki schne , M. (2015). On being he igh (cell) size, Science 348(6236): 1245075. G´omez, F., Fle a, C., Es eban, S., Qui ion, D., Pelleg ini, G., Lozano, M., P ezado, Y., Dos San os, M., Gua diola, C., Mon a ou, G. e al. (2016). Measu emen o ca bon ion mic odosime ic dis ibu ions wi h ul a hin 3d silicon diodes, Physics in Medicine & Biology 61(11): 4036–4047. Gua diola, C., Qui ion, D., Pelleg ini, G., Fle a, C., Es eban, S., Co ´es-Gi aldo, M., G´omez, F., Solbe g, T., Ca abe, A. & Lozano, M. (2015). Silicon-based h ee-dimensional mic os uc u es o adia ion dosime y in had on he apy, Applied Physics Le e s 107(2): 023505. IAEA (2008). Rela i e biological e ec i eness in ion beam he apy ( s 461), Technical epo , In e na ional A omic Ene gy Agency. Kliauga, P. (1990). Measu emen o single e en ene gy deposi ion spec a a 5 nm o 250 nm simula ed si e sizes, Radia ion P o ec ion Dosime y 31(1–4): 119–123. K ¨ame , M. & Scholz, M. (2000). T ea men planning o hea y-ion adio he apy: calcula ion and op imiza ion o biologically e ec i e dose, Physics in Medicine & Biology 45(11): 3319. Pagane i, H. (2014). Rela i e biological e ec i eness ( be) alues o p o on beam he apy. a ia ions as a unc ion o biological endpoin , dose, and linea ene gy ans e , Physics in Medicine & Biology 59(22): R419. Pa ke , S. I., Kenney, C. J. & Segal, J. (1997). 3d—a p oposed new a chi ec u e o solid-s a e adia ion de ec o s, Nuclea Ins umen s and Me hods in Physics Resea ch Sec ion A: Accele a o s, Spec ome e s, De ec o s and Associa ed Equipmen 395(3): 328–343. Pa icle The apy Co-Ope a i e G oup (2019). PTCOG home page. URL: h ps://www.p cog.ch/ Pelleg ini, G., Fe n´andez-Ma ´ınez, P., Baselga, M., Fle a, C., Flo es, D., G eco, V., Hidalgo, S., Mandi´c, I., K ambe ge , G., Qui ion, D. e al. (2014). Technology de elopmen s and i s measu emen s o low gain a alanche de ec o s (lgad) o high ene gy physics applica ions, Nuclea Ins umen s and Me hods in Physics Resea ch Sec ion A: Accele a o s, Spec ome e s, De ec o s and Associa ed Equipmen 765: 12–16. Pelleg ini, G., Ga cia, F., Balbuena, J., Cab uja, E., Lozano, M., O a a, R. & Ullan, M. (2009). Fab ica ion and simula ion o no el ul a- hin 3d silicon de ec o s, Nuclea Ins umen s and Me hods in Physics Resea ch Sec ion A: Accele a o s, Spec ome e s, De ec o s and Associa ed Equipmen 604(1-2): 115–118. Pelleg ini, G., Lozano, M., Ullan, M., Ba es, R., Fle a, C. & Pennica d, D. (2008). Fi s double-sided 3-d de ec o s ab ica ed a cnm-imb, Nuclea Ins umen s and Me hods in Physics Resea ch Sec ion A: Accele a o s, Spec ome e s, De ec o s and Associa ed Equipmen 592(1-2): 38–43. P ie o-Pena, J., G´omez, F., Fle a, C., Gua diola, C., Pelleg ini, G., Done i, M., Gio danengo, S., Gonz´alez-Cas a˜no, D. M. & Pa do-Mon e o, J. (2019). Mic odosime ic spec a measu emen s on a clinical ca bon beam a nominal he apeu ic luence a e wi h silicon cylind ical mic odosime e s, IEEE T ansac ions on Nuclea Science 66(7): 1840–1847. Radeka, V. (1974). Signal, noise and esolu ion in posi ion-sensi i e de ec o s, IEEE T ansac ions on Nuclea Science 21(1): 51–64. Spiele , H. (2005). Semiconduc o de ec o sys ems.