Dataset of Engineering Robust, Porous Guar Gum Hydrogels by One-Step Mild Synthesis: Impact of Porogen Choice on Rheology and Sustained Gastroretentive Amoxicillin Delivery

Página 1 de 8 Ti le: Enginee ing Robus , Po ous Gua Gum Hyd ogels by One-S ep Mild Syn hesis: Impac o Po ogen Choice on Rheology and Sus ained Gas o e en i e Amoxicillin Deli e y [Da ase ]. Au ho s: Fá ima Díaz-Ca asco; M.-Violan e de-Paz*; Ma ea Ka a ić; Es e anía Ga cía-Pulido; Ál a o San os-Medina; Lucía Muíña-Ramil; M. G acia Ga cía-Ma ín; Elena Beni o. * Co espondence: [email protected]. A ilia ion: Depa amen o de Química O gánica y Fa macéu ica, Uni e sidad de Se illa, C/ P o . Ga cía González, n.º 2, 41012-Se illa, España. Resea che email ORCID Fá ima Díaz-Ca asco [email protected] 0009-0001-5922-0548 M.-Violan e de-Paz* [email protected] 0000-0002-6544-4732 Ma ea Ka a ić --- Es e anía Ga cía-Pulido es ga [email protected] Ál a o San os-Medina al [email protected] Lucía Muíña-Ramil lucmui [email protected] M.-G acia Ga cía-Ma ín g [email protected] 0000-0002-7171-5236 Elena Beni o ebeni [email protected] 0000-0002-8796-6873 Página 2 de 8 Con en Ti le: .......................................................................................................................................... 1 Au ho s: ................................................................................................................................. 1 A ilia ion: .............................................................................................................................. 1 Keywo ds: .............................................................................................................................. 3 Abb e ia ions: ........................................................................................................................... 3 Da a o deg adabili y o GG-sys ems. ......................................................................................... 4 AMOX elease om single-s ep p epa ed and loaded o mula ions .............................................. 5 PEG used as po ogen ............................................................................................................. 5 (pH 2.0) .............................................................................................................................. 5 (pH 5.0) .............................................................................................................................. 5 Suc ose used as po ogen ....................................................................................................... 6 (pH 2.0) .............................................................................................................................. 6 (pH 5.0) .............................................................................................................................. 6 AMOX elease om pos -loaded IPN ........................................................................................... 7 PEG used as po ogen ............................................................................................................. 7 (pH 2.0) .............................................................................................................................. 7 (pH 5.0) .............................................................................................................................. 7 Suc ose used as po ogen ....................................................................................................... 8 (pH 2.0) .............................................................................................................................. 8 (pH 5.0) .............................................................................................................................. 8 Página 3 de 8 Keywo ds: Gua gum hyd ogel; In e pene a ing polyme ne wo k ; (IPN); Diels-Alde c osslinking; one-po syn hesis; po osi y modula ion; PEG po ogen; suc ose po ogen; Gas o e en i e d ug deli e y sys ems; GRDDS. Abb e ia ions: AMOX: amoxicillin; GG: gua gum; IPN: in e pene a ing polyme ne wo k; PEG: po osogen polye hylene glycol-350; Suc: po osogen suc ose; ₅₀ (h): ime (h) o 50% deg ada ion o o mula ion mass. Página 4 de 8 Da a o deg adabili y o GG-sys ems. NAME and pH* KEY Deg adabili y o e ime (h): pe cen age o IPN mass emaining ₅₀ (h)** 1 2 3 4 5 6 7 8 24 48 F1 (pH 2.0) GG-DA-AMOX25 82 72 66 61 56 46 38 33 11 0 5.02 F1 (pH 5.0) GG-DA-AMOX25 85 77 71 66 61 52 44 39 17 0 6.16 F2 (pH 2.0) GG-DA-AMOX40 79 67 60 54 49 39 31 26 7 0 3.94 F5 (pH 5.0) GG-DA-AMOX40 83 73 66 60 55 45 37 32 14 0 5.02 F3 (pH 2.0) GG-DA-PEG5-AMOX25 96 92 89 87 84 80 77 75 35 0 13.9 F3 (pH 5.0) GG-DA-PEG5-AMOX25 97 93 91 88 86 82 80 78 42 0 15.5 F4 (pH 2.0) GG-DA-PEG5-AMOX40 95 90 87 84 81 76 73 70 29 0 12.18 F4 (pH 5.0) GG-DA-PEG5-AMOX40 96 92 89 86 83 79 76 73 36 0 13.65 F5 (pH 2.0) GG-DA-PEG10-AMOX25 94 88 83 79 75 69 64 60 20 0 9.73 F5 (pH 5.0) GG-DA-PEG10-AMOX25 95 90 85 81 77 72 68 64 27 0 8.93 F6 (pH 2.0) GG-DA-PEG10-AMOX40 93 86 80 75 71 64 59 55 16 0 8.56 F6 (pH 5.0) GG-DA-PEG10-AMOX40 94 88 83 78 74 68 64 60 23 0 9.81 F7 (pH 2.0) GG-DA-PEG50-AMOX25 92 84 77 71 66 58 52 47 12 0 7.33 F7 (pH 5.0) GG-DA-PEG50-AMOX25 93 86 80 75 71 64 59 55 19 0 8.71 F8 (pH 2.0) GG-DA-PEG50-AMOX40 90 80 72 65 59 50 43 38 8 0 5.96 F8 (pH 5.0) GG-DA-PEG50-AMOX40 92 83 76 70 65 57 51 46 15 0 7.25 F9 (pH 2.0) GG-DA-Suc5-AMOX25 94 89 85 82 79 74 70 67 29 0 11.57 F9 (pH 5.0) GG-DA-Suc5-AMOX25 95 91 87 84 81 77 73 70 35 0 12.85 F10 (pH 2.0) GG-DA-Suc5-AMOX40 92 84 78 73 69 62 56 52 19 0 8.19 F10 (pH 5.0) GG-DA-Suc5-AMOX40 93 86 81 76 72 66 61 57 25 0 9.37 F11 (pH 2.0) GG-DA-Suc10-AMOX25 90 80 73 67 62 54 47 42 13 0 6.54 F11 (pH 5.0) GG-DA-Suc10-AMOX25 92 83 76 71 66 59 53 48 20 0 9.37 F12 (pH 2.0) GG-DA-Suc10-AMOX40 88 77 69 62 56 47 40 34 9 0 5.44 F12 (pH 5.0) GG-DA-Suc10-AMOX40 90 80 72 66 60 52 45 40 16 0 6.37 F13 (pH 2.0) GG-DA-Suc50-AMOX25 86 73 64 56 50 40 32 26 6 0 4.44 F13 (pH 5.0) GG-DA-Suc50-AMOX25 88 77 69 62 56 47 40 34 13 0 5.52 F14 (pH 2.0) GG-DA-Suc50-AMOX40 84 69 59 50 43 32 23 16 3 0 5.44 F14 (pH 5.0) GG-DA-Suc50-AMOX40 87 74 64 56 49 39 31 25 10 0 4.47 * pH a which he deg ada ion s udy was conduc ed; ** Time (h) o 50% deg ada ion o o mula ion mass Página 5 de 8 AMOX elease om single-s ep p epa ed and loaded o mula ions PEG used as po ogen (pH 2.0) AMOX elease om single-s ep p epa ed and loaded o mula ion (PEG, pH 2.0) PEG5-AMOX25 PEG5-AMOX40 PEG10-AMOX25 PEG10-AMOX40 PEG50-AMOX25 PEG50-AMOX40 Time (h) F3 e o F4 ERROR F5 e o F6 ERROR 7 ERROR F8 ERROR 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 1.00 44.27 2.39 60.88 3.04 20.79 2.27 55.72 2.79 17.34 0.15 13.49 0.70 2.00 54.21 1.94 80.97 1.62 27.78 0.08 67.89 1.36 22.17 2.60 16.75 0.41 3.00 78.83 13.32 85.95 4.30 29.95 1.69 70.06 3.50 22.24 1.14 17.62 0.50 5.00 71.59 0.47 94.44 0.94 31.00 0.75 77.19 0.77 23.62 0.07 18.91 0.71 8.00 82.41 1.45 100.00 2.00 36.56 1.95 78.59 1.57 26.48 1.67 19.63 0.71 (pH 5.0) AMOX elease om single-s ep p epa ed and loaded o mula ion (PEG, pH 5.0) PEG5-AMOX25 PEG5-AMOX40 PEG10-AMOX25 PEG10-AMOX40 PEG50-AMOX25 PEG50-AMOX40 Time (h) F3 e o F4 ERROR F5 e o F6 ERROR 7 ERROR F8 ERROR 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 1.00 42.82 8.11 60.54 3.03 19.30 1.61 27.46 1.37 32.17 4.65 12.00 2.09 2.00 51.36 3.72 77.20 3.09 22.44 0.66 38.34 1.53 18.46 0.75 13.31 0.32 3.00 57.99 2.21 78.73 3.94 25.88 0.15 47.37 2.37 19.78 0.67 15.28 0.43 5.00 94.57 3.95 88.24 2.65 27.88 0.15 55.57 1.67 21.31 0.51 16.75 0.31 8.00 78.64 6.98 89.99 4.50 30.60 0.10 62.54 3.13 24.12 0.95 18.64 0.35 Página 6 de 8 Suc ose used as po ogen (pH 2.0) AMOX elease om single-s ep p epa ed and loaded o mula ion (Suc, pH 2.0) Suc5-AMOX25 Suc5-AMOX40 Suc10-AMOX25 Suc10-AMOX40 Suc50-AMOX25 Suc50-AMOX40 Time (h) F9 e o F10 ERROR F11 e o F12 ERROR F13 ERROR F14 ERROR 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 1.00 26.19 0.76 14.39 0.50 20.84 0.51 17.17 0.08 15.96 2.05 9.63 4.35 2.00 34.66 0.91 17.94 0.88 16.59 0.38 20.64 1.19 17.37 0.31 11.77 3.05 3.00 40.90 1.58 20.26 0.71 18.46 1.32 35.12 4.57 20.55 0.25 13.83 2.26 5.00 74.96 1.54 36.46 0.84 22.02 0.93 28.20 2.52 22.80 0.17 14.67 1.99 8.00 65.55 1.04 37.28 4.05 25.27 0.09 27.60 2.77 24.76 0.51 17.00 2.12 (pH 5.0) AMOX elease om single-s ep p epa ed and loaded o mula ion (Suc, pH 5.0) Suc5-AMOX25 Suc5-AMOX40 Suc10-AMOX25 Suc10-AMOX40 Suc50-AMOX25 Suc50-AMOX40 Time (h) F9 e o F10 ERROR F11 e o F12 ERROR F13 ERROR F14 ERROR 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 1.00 45.97 0.61 16.66 1.41 8.65 0.14 11.09 1.46 17.09 0.08 14.59 0.11 2.00 40.22 3.80 16.73 0.04 40.23 0.08 24.18 2.05 43.07 1.13 20.20 0.23 3.00 55.75 3.33 18.83 1.05 49.88 0.16 25.24 2.63 46.57 1.12 20.65 0.12 5.00 70.56 1.15 19.92 1.21 56.17 0.43 27.49 0.02 47.81 1.83 21.13 0.42 8.00 72.00 4.66 21.88 1.72 61.00 0.66 29.58 0.04 44.33 2.11 23.26 0.59 Página 7 de 8 AMOX elease om pos -loaded IPN PEG used as po ogen (pH 2.0) AMOX elease om pos -loaded IPN (PEG, pH 2.0) PEG5-AMOX25 PEG5-AMOX40 PEG10-AMOX25 PEG10-AMOX40 PEG50-AMOX25 PEG50-AMOX40 Time (h) B3.4-AMOX25 e o B3.4-AMOX40 ERROR B5.6-AMOX25 e o B5.6-AMOX40 ERROR B7.8-AMOX25 ERROR B7.8-AMOX40 ERROR 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 1.00 32.70 3.23 48.84 2.10 17.72 7.66 1.64 0.12 9.30 8.02 8.39 7.25 2.00 50.61 9.66 57.11 5.98 44.33 3.59 39.11 8.67 41.73 1.48 44.40 14.91 3.00 61.34 0.28 52.70 3.45 57.56 0.33 55.65 1.73 54.87 4.73 57.76 6.86 5.00 69.99 1.63 60.05 1.98 81.43 0.59 60.29 2.03 65.72 0.32 61.92 0.29 8.00 72.49 0.41 61.54 0.82 91.06 2.33 63.73 0.34 75.68 5.81 63.99 0.89 (pH 5.0) AMOX elease om pos -loaded IPN (PEG, pH 5.0) PEG5-AMOX25 PEG5-AMOX40 PEG10-AMOX25 PEG10-AMOX40 PEG50-AMOX25 PEG50-AMOX40 Time (h) B3.4-AMOX25 e o B3.4-AMOX40 ERROR B5.6-AMOX25 e o B5.6-AMOX40 ERROR B7.8-AMOX25 ERROR B7.8-AMOX40 ERROR 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 1.00 36.87 1.21 22.77 0.86 10.54 9.27 9.38 6.62 0.86 0.23 1.07 0.07 2.00 53.54 10.91 41.76 2.42 34.89 10.86 32.51 8.79 17.12 2.08 17.46 3.93 3.00 64.59 1.30 45.12 4.76 48.24 9.58 43.92 1.47 34.41 3.85 35.78 3.89 5.00 69.39 0.90 58.10 3.18 67.67 7.54 49.01 0.78 53.69 14.98 40.34 2.17 8.00 71.39 0.25 65.16 4.78 68.61 6.32 75.06 12.24 76.38 4.08 53.77 3.51 Página 8 de 8 Suc ose used as po ogen (pH 2.0) AMOX elease om pos -loaded IPN (Suc, pH 2.0) Suc 5% Suc 10% Suc 50% B9.10-AMOX25 B9.10-AMOX40 B11.12-AMOX25 B11.12-AMOX40 B13.14-AMOX25 B13.14-AMOX40 (h) AMOX 25% e o 40% ERROR 25% e o 40% ERROR 25% e o 40% ERROR 0 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 1 56.89 13.61 55.83 4.80 11.09 8.67 7.16 1.51 65.66 20.76 52.98 3.87 2 74.19 3.63 60.59 0.67 60.34 20.27 23.13 7.62 69.28 6.25 59.31 2.03 3 92.36 18.20 68.62 0.18 60.16 4.82 40.99 6.89 84.02 3.86 69.88 6.77 5 93.10 11.70 75.60 2.79 60.56 3.69 43.76 6.56 79.79 0.13 70.09 7.51 8 100.00 11.45 79.65 3.82 63.09 2.16 44.43 6.48 82.78 0.22 71.63 9.88 (pH 5.0) AMOX elease om pos -loaded IPN (Suc, pH 5.0) Suc 5% Suc 10% Suc 50% B9.10-AMOX25 B9.10-AMOX40 B11.12-AMOX25 B11.12-AMOX40 B13.14-AMOX25 B13.14-AMOX40 (h) AMOX 25% e o 40% ERROR 25% e o 40% ERROR 25% e o 40% ERROR 0 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 1 59.43 15.26 51.46 5.45 11.90 1.23 14.24 2.25 55.43 20.61 7.25 0.33 2 78.96 1.14 61.12 6.69 32.25 2.27 31.19 8.62 70.63 7.32 53.73 3.21 3 86.62 2.79 67.64 7.18 56.32 10.26 39.69 10.51 78.75 3.05 63.98 4.73 5 96.00 2.19 72.10 5.97 61.82 5.74 42.97 10.46 83.61 0.49 71.23 6.04 8 100.1 9.57 72.29 2.86 62.00 6.73 44.22 8.63 83.36 0.30 70.57 2.39