Metabolic preference studies in cells of the tumor microenvironment

Metabolic preference studies in cells of the tumor microenvironment Mª Carmen Ocaña1, Beatriz Martínez-Poveda1, Ana R. Quesada1, 2, Miguel Ángel Medina1, 2 1Universidad de Málaga, Andalucía Tech, Departamento de Biología Molecular y Bioquímica, Facultad de Ciencias e IBIMA (instituto de Biomedicina de Málaga), Málaga, ES, MÁLAGA, Spain 2Unidad 741, CIBER de Enfermedades Raras (CIBERER)., MÁLAGA, Spain In the last years, the rediscovery of the Warburg effect and high tumoral glutaminolysis has lead to a renewed interest in cancer metabolism. Moreover, recent studies have put some importance in endothelial cells metabolism. Inquiring into the metabolism of accompanying cells of the tumor microenvironment, such as endothelial and immune cells, could shed some light in the search for alternative cancer therapeutic approaches. In this work the use of glucose, glutamine and palmitate as metabolic fuels by endothelial and tumoral cells is studied. In addition, we also test if two antiangiogenic compounds previously described by our group are able to modify key steps of endothelial and/or tumor cells metabolism [Our experimental work is supported by grants BIO2014-56092-R (MINECO and FEDER) and P12-CTS-1507 (Andalusian Government and FEDER) and funds from group BIO-267 (Andalusian Government). The "CIBER de Enfermedades Raras" is an initiative from the ISCIII (Spain)]. This communicaction has the support of a travel grant "Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech