Synthesis of silacyclopent-2-en-4-ols via intramolecular [2 + 2] photocycloaddition of benzoyl(allyl)silanes

This is a self-archived version of an original article. This version may differ from the original in pagination and typographic details. Author(s): Title: Year: Version: Copyright: Rights: Rights url: Please cite the original version: CC BY-NC 3.0 https://creativecommons.org/licenses/by-nc/3.0/ Synthesis of silacyclopent-2-en-4-ols via intramolecular [2 + 2] photocycloaddition of benzoyl(allyl)silanes © Authors, 2019 Published version Vale, Joao R.; Valkonen, Arto; Afonso, Carlos A. M.; Candeias, Nuno R. Vale, J. R., Valkonen, A., Afonso, C. A. M., & Candeias, N. R. (2019). Synthesis of silacyclopent-2en-4-ols via intramolecular [2 + 2] photocycloaddition of benzoyl(allyl)silanes. Organic Chemistry Frontiers, 6(22), 3793-3798. https://doi.org/10.1039/C9QO01028A 2019 ORGANIC CHEMISTRY FRONTIERS RESEARCH ARTICLE Cite this: Org. Chem. Front., 2019, 6, 3793 Received 21st August 2019, Accepted 10th October 2019 DOI: 10.1039/c9qo01028a rsc.li/frontiers-organic Synthesis of silacyclopent-2-en-4-ols via intramolecular [2 + 2] photocycloaddition of benzoyl(allyl)silanes† João R. Vale, a,b Arto Valkonen, c Carlos A. M. Afonso * b and Nuno R. Candeias * a Organosilicon compounds are versatile units with a wide range of uses from medicinal chemistry to the field of organic electronics. An unprecedented method for the synthesis of novel diaryl-substituted silacyclopentenols via blue-light promoted intramolecular [2 + 2] photocycloaddition of acyl silanes is herein disclosed. Additionally, the present findings demonstrate the influence of the olefin substituents in controlling the regioselectivity of the intramolecular Paternò–Büchi reaction, providing silacycles different from previously reported ones. The high degree of functionalization of these compounds makes them attractive precursors to other synthetically challenging silacyclopentanes. Introduction The incorporation of silicon into an organic molecule can alter some of its physical and chemical properties, making organosilicon compounds attractive candidates for medicinal chemistry. 1,2 Although silicon is an isostere of sp 3 -hybridised carbon, replacing carbon by silicon can: alter reactivity, increase lipophilicity, induce different conformations and increase ring sizes. 1 Organosilicons have the tendency to form pentaand hexa-coordinated species 3,4 and labile Si–O, Si–N and Si–H bonds in aqueous media. Moreover, polarised C–Si bounds have increased reactivity as compared to C–C bounds. Because of these features, organosilicon compounds have shown considerable potential in the medicinal chemistry field over the past 55 years. 1 The virtually simple replacement of carbon by silicon in a known drug or scaffold has been widely explored in the design of new bioactive compounds. 5,6 Drastic changes in the pharmacological profiles of silicon bioisoster of venlafaxine, 7 haloperidol 8 and bexarotene 9 have been previously reported, including improvements in the selectivity profile or lower toxicity of the drug metabolites. Notwithstanding the role of silicon in drug discovery, 2 organosilicon compounds have also gained notoriety in molecular electronics 10 and polymer science. 11 Conjugated organosilicon materials are particularly promising for the organic electronics and photonics field. 12 The insertion of silicon atoms in conjugated organic motifs changes the HOMO and LUMO energy levels, creating a new broad class of important semiconductors. The 5-membered conjugated silacycle silole is a particularly interesting building block in this research area and in the development of silicon-containing polymers. 13 Given the natural abundance of silicon and its lack of intrinsic toxicity, processes targeting the synthesis of organosilanes 14 and the modification of C–Si bonds are becoming more available. 15 Despite the versatility and importance of silacycles, methods for their preparation are somewhat scarce. 16 Silacyclobutanes (SCBs) are generally synthetised by the convenient intramolecular silylation of in situ prepared Grignard reagents. 16 Due to their high ring strain and Lewis acidity, SCBs are often used as precursors to other organosilicon compounds through ring opening/expansion reactions catalysed by transition metals. 16,17 Even though ring expansion of SCBs can also provide silacyclopentanes under specific conditions, the most direct method for their synthesis consists in the addition of metal treated 1,3-butadienes to dichlorosilanes. 18,19 The synthesis of silacyclopentenes through palladium-catalysed silylene-1,3-diene [4 + 1] cycloaddition 20 allows flexibility on substitution of the cyclopentene core. Considering the importance of the cyclopentane motif in bioactive compounds, 21–26 we reasoned that new methods for the preparation of 5 membered-ring silacycles are needed for several fields of molecular sciences. From a synthetic perspec- †Electronic supplementary information (ESI) available: Experimental protocols and NMR, computational and X-ray diffraction data. CCDC 1935510 and 1935511. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c9qo01028a a Faculty of Engineering and Natural sciences, Tampere University, Korkeakoulunkatu 8, 33101 Tampere, Finland. E-mail: nuno.rafaelca[email protected] b Instituto de Investigação do Medicamento (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, Av. Prof. Gama Pinto, 1649-003 Lisboa, Portugal. E-mail: carlosafonso@ff.ulisboa.pt c Department of Chemistry, University of Jyvaskyla, P.O. Box 35, 40014 Jyväskylä, Finland This journal is © the Partner Organisations 2019 Org. Chem. Front.,2019,6,3793–3798 | 3793 Open Access Article. Published on 12 October 2019. Downloaded on 11/22/2019 7:31:28 AM. This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence. View Article Online View Journal | View Issue tive, achieving the cyclopentene moiety would be preferable due to potentially further functionalization of the double bound, such as asymmetric oxidative transformations. 27,28 Silacyclopent-2-enes are especially challenging as the ring is usually constructed from a highly functionalised silane (Scheme 1a), 29–31 imposing limitations on the degree of substitution on the cyclic core. Further modifications of silacyclopent-2-enes have also been reported 32–35 but additional functionalization of the cyclopentene ring is rare and synthetic flexibility on olefin substitution is often limited. Amongst the aforementioned scaffold, silacyclopent-2-enes bearing an allylic alcohol are of particular interest. Tomooka’s group has utilised such compounds in the synthesis of various functionalised silacylclopentanes, some presenting biological activity, via Mitsunobu, Tsuji–Trost, and other transformations. 34,35 Additionally, similar silacyclopent-2-en-4-ols have been used in the synthesis of a polyol motif present in several natural products. 36 In 2008, Portella et al. reported a photochemical [2 + 2] cycloaddition of acylsilanes (Scheme 1b). 37 Upon irradiation, acyl(allyl)silanes undergo intramolecular Paternò–Büchi reaction, producing bicyclic oxetanes in moderate to good yields and providing a new method for the synthesis of SCBs. While new 1-alky-6-oxa-2-silabicyclo[2.2.0]hexanes could be prepared by this way, irradiation of benzoyl(allyl)silane resulted in an intractable reaction mixture. Since the relative stability of the triplet biradical intermediates in the Paternò–Büchi reaction plays an important role in its stereoand regioselectivity, 38,39 we envisioned that substitution on the olefin moiety with a radical stabilising group could tame the reactivity of the intermediates, altering the reaction profile observed by Portella. This could alter the regioselectivity of the cycloaddition, and the subsequent oxetane ring-opening would eventually yield silacyclopentenols (Scheme 1c). Acylsilanes have attracted immense scientific interest since their first preparation by Brook in 1957. 40 Despite the extensive research conducted on these compounds in the past few decades, 41–43 novel methodologies that utilize acylsilanes as powerful reagents in organic chemistry are still being reported. 44–46 Experimentally, the use of aromatic acylsilanes is particularly attractive as they do not undergo side reactions involving the carbonyl α-carbon. 47 Moreover, they show an absorption maximum at around 425 nm, thus allowing photoexcitation using visible blue light. The handling of acylsilanes requires special precautions as they are known to undergo Brook rearrangement to a reactive carbene after photoirradiation or thermal conditions. This carbene has been shown to undergo insertion reactions in polarised heteroatomhydrogen bounds, 48,49 cycloadditions to aldehydes 50 and alkynes, 51,52 cross-coupling reaction with organoboronic esters 53 and even C–H insertions 54–56 under harsher conditions. Carbene formation and its subsequent reactions are then possible competitive destructive pathways to the [2 + 2] photocycloaddition. This influence can be minimised by using dry, aprotic solvents and by protecting free alcohols or amines in the acylsilane starting material. Results and discussion To investigate our hypothesis, cinnamyl silane 3a was synthesised (Scheme 2). Initial investigations using the dithiane umpolung approach failed as the harsh conditions required for the deprotection of the dithiane moiety were incompatible with the olefin group. Inspired by Portella’s success in the synthesis of acyl(allyl)silanes using benzotriazole hemiaminals as umpolung equivalents of aldehydes, 37,57 we adopted a similar synthetic pathway. This strategy, originally developed by Katritzky, 58 benefits from facile late-stage hydrolysis of the hemiaminals to the corresponding carbonyls. Olefin crossmetathesis was performed on intermediate 2a, as the acylsilane moiety seems to inhibit the Grubbs catalyst. 57 Scheme 1 Methods for construction of silacyclopent-2-enes and photocycloaddition of acylsilanes. Scheme 2 Synthesis of benzoylsilanes 3. Research Article Organic Chemistry Frontiers 3794 |Org. Chem. Front.,2019,6,3793–3798 This journal is © the Partner Organisations 2019 Open Access Article. Published on 12 October 2019. Downloaded on 11/22/2019 7:31:28 AM. This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence. View Article Online Gratifyingly, 3a was obtained in reasonable 53% yield after hydrolysis. Compound 3a was irradiated with blue-light for 5 hours in dry hexane, and complete consumption of the starting material was observed (Scheme 3). NMR analysis showed that oxetane 4a was cleanly obtained as a mixture of two diastereoisomers (syn/anti = 1 : 2), resulting from the [2 + 2] photocycloaddition reaction. Notably, reverse regioselectivity in the Paternò–Büchi reaction was observed by Portella et al. 37 for unsubstituted acyl(allyl)silanes (Scheme 1b). Compound 4a proved to be unstable to silica column purification and overall acidic conditions, producing alcohol 5a and other products. After optimization, we found that treating 4a with catalytic NaHSO 4 in tert-butanol leads to complete and selective isomerization to 5a, in 82% overall yield. Its structure was proven through esterification with 3,5-dinitrobenzoylchloride to yield 6a and following single crystal X-ray diffraction analysis of the obtained ester. Realising the potential of the photocycloaddition–isomerization sequence as a direct and selective way to obtain 2,3-arylsubstituted silacyclopent-2-en-4-ols, we synthesised a series of acylsilanes 3to be submitted to the same transformation (Scheme 2). Sila-hemiaminals 2were obtained in very good yields, containing a wide range of functional groups in the aryl moiety. Nitro-substituted aromatics however failed to add to the silylchloride reagent, presumably due to the low nucleophilicity of the lithiated intermediate. Issues related with the instability of the lithiated anion of 1bearing electron-rich groups in Ar 1 were overcome by tBuLi addition to a stirring solution of 1and silyl chloride. The syntheses proceeded with cross-metathesis of intermediates 2with styrenes. Low to moderate yields were obtained in some cases due to incomplete conversion of 2, as the dimerization of styrene to stilbene was a fast competitive reaction. 2-Pyrididyl, 4-cyanoand 4-dimethylamine-benzene resulted in complete deactivation of the catalyst, as no reactions were observed after several days at reflux. The detrimental effect of nitrogen bases and N-heterocycles in metathesis reaction is known and still a problematic issue in this field. 59 Despite the synthetic challenges, a series of seventeen arylsubstituted acylsilanes 3were obtained and tested in the intramolecular [2 + 2] photocycloaddition reaction (Scheme 4). The reaction scope appears to be quite vast, withstanding electron withdrawing and electron donating substituents, as well as ortho,meta and para substitution. Gratifyingly, both variations at 3and 2-positions of the 2,3-diaryl-silacyclopent-2-ene-4-ol could be performed. The reaction tolerates the presence of substituents prone for further derivatization such as acetyl (5e), nitrile (5g), aldehyde (5h) and silyl ether (5n). Formation of sulfur heterocycle derivative 5o contrasts with its oxygen homologue 5p, for which only traces could be observed. Also ortho-methyl substitution on the ketone side (Ar 1 ) led to the recovery of starting material even after 8 hours of irradiation. In order to better understand the dramatic change in regioselectivity of the [2 + 2] photocycloaddition of 3a compared to its terminal olefin analogues, DFT calculations were performed and the energies of the possible biradical intermediates comScheme 3 [2 + 2] photocycloaddition of cinnamyl silane 3a, acidcatalysed isomerization to 5a, and crystal structure of 3,5-dinitrobenzoylated 6a. Scheme 4 Scope of the [2 + 2] photocycloaddition of benzoylsilanes 3. a PPTS (10%) was used instead of NaHSO 4 . b No acid treatment was needed. Organic Chemistry Frontiers Research Article This journal is © the Partner Organisations 2019 Org. Chem. Front.,2019,6,3793–3798 | 3795 Open Access Article. Published on 12 October 2019. Downloaded on 11/22/2019 7:31:28 AM. This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence. View Article Online pared (see ESI†for details). The Paternò–Büchi photocycloaddition typically occurs through reaction of a carbonyl compound in the excited state with an alkene in the ground state. Time dependent DFT studies on 3a and 7show that the first vertical transition corresponds to populating the singlet excited state with comparable energies for both molecules (ca. 64 kcal mol −1 , Scheme 5a), through a carbonyl n →π* transition between HOMO−1 and LUMO, as can be observed in the case of 3a (Scheme 5b). As triplet excited states for both molecules are generally ca. 11 kcal mol −1 more stable than their singlet counterparts, they likely undergo intersystem spin crossing. Analysis of the molecular orbitals of 3a T1 verifies that LSOMO and HSOMO correspond to the half-occupied n and π* carbonyl orbitals, respectively (Scheme 5c). The two paths concerning the attack of the carbonyl oxygen of the triplet excited state to the olefin moiety of the allylsilane were considered‡(Scheme 6). Comparing the formation of the two biradical species upon either exo and endo attacks of the oxygen to the cinnamyl moiety, a preference would be expected towards the former path due to stabilization of the radicals by the aromatic ring in 3a :br 5 . The less than 1 kcal mol −1 difference in the stabilities of the biradicals derived from 7nevertheless suggests two competing mechanisms. Since, when starting from aliphatic acyl(allyl)silanes, Portella et al. observed the exclusive formation of the 6-endo-trig cyclizationderived product (Scheme 1b), benzoylsilane 7was synthesised and irradiated in order to determine the effect of the carbonyl substituent on the reaction outcome. After irradiation of 7in hexane for 8 hours, we observed complete and clean conversion to the structural isomers 8and 9, in 1 to 1.5 ratio, respectively (Scheme 7). Both compounds proved to be unstable to silica column chromatography. Indirect detection of compound 9was possible after acid treatment with PPTS and isomerization to the isolable allylic alcohol 10 in 41% overall yield, which was further functionalised with 3,5-dinitrobenzoyl chloride to give ester 11 for X-ray diffraction analysis (Scheme 7). Despite the many attempts in isolating compound 8or its decomposition products, we could only verify its presence through identification of characteristic peaks in 1 H and 13 C NMR spectra of the reaction mixture, in accordance with previous oxetanes characterization by Portella et al. 37 (Scheme 1b). Experimentally, the lack of regioselectivity for the cycloaddition of compound 7is in agreement with its DFT predicted reactivity, highlighting the need of a radical stabilising group connected to the olefin in order to promote complete regioselectivity towards the 5-exo-trig pathway. In order to demonstrate the versatility of these unprecedented 2,3-disubstituted silacyclopentenols as precursors to other silacyclopentanes, compound 5a was subjected to known transformations (Scheme 8). Diastereoselective epoxidation with m-CPBA quantitatively delivered 12a, a candidate precursor to a series of polyols. Ethanolysis of a transient carbocation formed after acid treatment of 5a yielded ether 13a.In addition, olefin reduction with 1 atm of hydrogen in the presScheme 6 Proposed mechanism for the intramolecular [2 + 2] photocycloaddition of acylsilanes. Scheme 7 Irradiation of benzoyl(allyl)silane 7and its non-regioselective [2 + 2] cycloaddition. Scheme 5 (a) Energy profile for excited states population of acylsilanes 3a and 7. Free energies of the species are indicated in italics (kcal mol −1 ), referring to corresponding acylsilane in ground state. (b) Representation of most significant molecular orbitals involved in first vertical excitation of 3a. (c) Single occupied orbitals of 3a. ‡The possible intermediates involved in the paths derived from the attack of the carbonyl carbon to the olefin moiety were also considered, although leading to biradicals considerably higher in energy (see ESI†). Research Article Organic Chemistry Frontiers 3796 |Org. Chem. Front.,2019,6,3793–3798 This journal is © the Partner Organisations 2019 Open Access Article. Published on 12 October 2019. Downloaded on 11/22/2019 7:31:28 AM. This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence. View Article Online ence of catalytic palladium on carbon quantitatively yields the silacyclopentanol 14a as mixture of two diastereoisomers (syn/anti = 1.4 : 1). Finally, inspired by the structural similarity of selective COX-2 enzyme inhibitors 60 derived from cyclopentane, the removal of the hydroxyl functionality of 5a was attempted. Gratefully, use of Yamamoto’s HSiEt 3 /catalytic B(C 6 F 5 ) 3 system 61 allowed deoxygenation to 15a in reasonable yield. The use of such compounds as bioisosteres of cyclopentanes could pave the way in the adoption of the new intramolecular [2 + 2] photocycloaddition in the silicon/carbon switch strategy. Oxidation of allylic alcohol 5a was accomplished using excess MnO 2 in cold DCM, giving ketone 16a quantitatively. Low temperatures are vital as 16a proved to easily isomerize to the silyl enol ether 17a under thermal conditions. Conclusions In conclusion, we have developed a methodology for the synthesis of novel 2,3-diaryl silacyclopent-2-en-4-ols. This strategy involved the synthesis of olefin-substituted benzoyl(allyl) silanes through the benzotriazole umpolung and metathesis reactions. Blue-light irradiation of these molecules promotes a [2 + 2] photocycloaddition reaction with complete regioselectivity, governed by the stability of the biradical intermediate as supported by computational calculations. Acid-promoted isomerization yields, to the best of our knowledge, the so far unavailable 2,3-disubstituted silacyclopentenols. Moreover, this study expands the rather short collection of intramolecular Paternò–Büchi reaction examples while demonstrating the influence of the olefin substituents in controlling the regioselectivity of such reaction. The obtained compounds may be used as versatile precursors to other silacyclopentanes that could find their use in the silicon/carbon switch approach in medicinal chemistry as bioisosters of bioactive cyclopentanes, or as organosilicon motifs in organic electronics. Conflicts of interest There are no conflicts to declare. Acknowledgements The Academy of Finland is duly acknowledged for financial support to N. R. C. (Decisions No. 326487 and 326486) and to A. V. (No. 314343). Fundação para a Ciência e Tecnologia (FCT) is acknowledged for financial support to JRV (SFRH/BD/ 120119/2016). CSC-IT Center for Science Ltd, Finland is acknowledged for the allocation of computational resources. Notes and references 1 A. K. Franz and S. O. Wilson, J. Med. Chem., 2013, 56, 388– 405. 2 E. Rémond, C. Martin, J. Martinez and F. Cavelier, Chem. Rev., 2016, 116, 11654–11684. 3A.D.DilmanandS.L.Ioffe, Chem. Rev., 2003, 103,733–772. 4 S. Rendler and M. Oestreich, Synthesis, 2005, 1727–1747. 5 R. Tacke and S. Dörrich, Atypical Elements in Drug Design, 1st edn, 2014. 6 R. Ramesh and D. S. Reddy, J. Med. Chem., 2017, 61, 3779– 3798. 7 O. Daiss, C. Burschka, J. S. Mills, J. G. Montana, G. A. Showell, J. B. H. Warneck and R. Tacke, Organometallics, 2006, 25, 1188–1198. 8 R. Tacke, F. Popp, B. Müller, B. Theis, C. Burschka, A. Hamacher, M. U. Kassack, D. Schepmann, B. Wünsch, U. Jurva and E. Wellner, ChemMedChem, 2008, 3, 152–164. 9 J. B. Bauer, W. P. Lippert, S. Dörrich, D. Tebbe, C. Burschka, V. B. Christie, D. M. Tams, A. P. Henderson, B. A. Murray, T. B. Marder, S. A. Przyborski and R. Tacke, ChemMedChem, 2011, 6, 1509–1517. 10 T. A. Su, H. Li, R. S. Klausen, N. T. Kim, M. Neupane, J. L. Leighton, M. L. Steigerwald, L. Venkataraman and C. Nuckolls, Acc. Chem. Res., 2017, 50, 1088–1095. 11 R. L. N. Hailes, A. M. Oliver, J. Gwyther, G. R. Whittell and I. Manners, Chem. Soc. Rev., 2016, 45, 5358–5407. 12 S. A. Ponomarenko and S. Kirchmeyer, Adv. Polym. Sci., 2011, 235,33–110. 13 J. Chen and Y. Cao, Macromol. Rapid Commun., 2007, 28, 1714–1742. 14 J. V. Obligacion and P. J. Chirik, Nat. Rev. Chem., 2018, 2, 15–34. Scheme 8 Examples of chemical transformations of 5a. Organic Chemistry Frontiers Research Article This journal is © the Partner Organisations 2019 Org. Chem. Front.,2019,6,3793–3798 | 3797 Open Access Article. Published on 12 October 2019. Downloaded on 11/22/2019 7:31:28 AM. This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence. View Article Online 15 T. Komiyama, Y. Minami and T. Hiyama, ACS Catal., 2017, 7, 631–651. 16 Q. C. Mu, J. Chen, C. G. Xia and L. W. Xu, Coord. Chem. Rev., 2018, 374,93–113. 17 H. Chen, Y. Chen, X. Tang, S. Liu, R. Wang, T. Hu, L. Gao and Z. Song, Angew. Chem., Int. Ed., 2019, 58, 4695–4699. 18 G. Manuel, P. Mazerolles and E. T. J. Florence, J. Organomet. Chem., 1971, 30,5–19. 19 G. K. Henry, R. Shinimoto, Q. Zhou and W. P. Weber, J. Organomet. Chem., 1988, 350,3–8. 20 T. Ohmura, K. Masuda, I. Takase and M. Suginome, J. Am. Chem. Soc., 2009, 131, 16624–16625. 21 D. S. Straus and C. K. Glass, Med. Res. Rev., 2001, 21, 185– 210. 22 S. M. Roberts, M. Gabriella and E. S. Sickle, J. Chem. Soc., Perkin Trans. 1, 2002, 1735–1742. 23 H. Almahli, Curr. Top. Med. Chem., 2017, 17, 2903–2912. 24 Z. Sevcikova, M. Pour, D. Novak, J. Ulrichova and J. Vacek, Mini-Rev. Med. Chem., 2014, 14, 322–331. 25 B. Heasly, Curr. Org. Chem., 2014, 18, 641–686. 26 S. P. Simeonov, P. M. Nunes, K. Guerra, V. B. Kurteva and C. A. M. Afonso, Chem. Rev., 2016, 116, 5744–5893. 27 H. C. Kolb, M. S. VanNieuwenhze and K. B. Sharpless, Chem. Rev., 1994, 94, 2483–2547. 28 A. Pfenninger, Synthesis, 1986, 89–116. 29 N. Asao, T. Shimada, T. Shimada and Y. Yamamoto, J. Am. Chem. Soc., 2001, 123, 10899–10902. 30 B. Wrackmeyer, O. L. Tok and R. Kempe, Inorg. Chim. Acta, 2005, 358, 4183–4190. 31 T. Ohmura, I. Sasaki and M. Suginome, Org. Lett., 2019, 21, 1649–1653. 32 A. C. Stevens and B. L. Pagenkopt, Org. Lett., 2010, 12, 3658–3661. 33 D. Liu and S. A. Kozmin, Angew. Chem., Int. Ed., 2001, 40, 4757–4759. 34 K. Igawa, D. Yoshihiro, Y. Abe and K. Tomooka, Angew. Chem., Int. Ed., 2016, 55, 5814–5818. 35 K. Igawa, A. Kuroo, D. Yoshihiro, Y. Yamanaka and K. Tomooka, Synlett, 2017, 28, 2445–2448. 36 D. Liu and S. A. Kozmin, Org. Lett., 2002, 4, 3005–3007. 37 C. Hammaecher and C. Portella, Chem. Commun., 2008, 5833. 38 M. Abe, T. Kawakami, S. Ohata and K. Nozaki, J. Am. Chem. Soc., 2004, 126, 2838–2846. 39 F. Kong, B. Zhai and Q. Song, Photochem. Photobiol. Sci., 2008, 7, 1332–1336. 40 A. G. Brook, J. Am. Chem. Soc., 1957, 79, 4373–4375. 41 A. Ricci and A. Degl’Innocenti, Synthesis, 1989, 647–660. 42 P. C. B. Page, S. S. Klair and S. Rosenthal, Chem. Soc. Rev., 1990, 19, 147. 43 H.-J. Zhang, D. L. Priebbenow and C. Bolm, Chem. Soc. Rev., 2013, 42, 8540–8571. 44 J. Y. Lv, Z. Xu, Z. J. Zheng, L. Li, Y. M. Cui, J. Cao, K. F. Yang and L. W. Xu, RSC Adv., 2017, 7, 54934– 54938. 45 F. G. Zhang and I. Marek, J. Am. Chem. Soc., 2017, 139, 8364–8370. 46 L. Capaldo, R. Riccardi, D. Ravelli and M. Fagnoni, ACS Catal., 2018, 8, 304–309. 47 A. G. Brook and J. M. Duff,Can. J. Chem., 1973, 51, 352– 360. 48 J. M. Duffand A. G. Brook, Can. J. Chem., 1973, 51, 2869– 2883. 49 H. Watanabe, T. Kogure and Y. Nagai, J. Org. Chem., 1972, 43, 285–291. 50 A. G. Brook and J. B. Pierce, Can. J. Chem., 1971, 49, 1622– 1628. 51 H. J. Zhang, P. Becker, H. Huang, R. Pirwerdjan, F. F. Pan and C. Bolm, Adv. Synth. Catal., 2012, 354, 2157– 2161. 52 P. Becker, D. L. Priebbenow, H. J. Zhang, R. Pirwerdjan and C. Bolm, J. Org. Chem., 2014, 79, 814–817. 53 K. Ito, H. Tamashima, N. Iwasawa and H. Kusama, J. Am. Chem. Soc., 2011, 133, 3716–3719. 54 A. R. Bassindale, A. G. Brook and J. Harris, J. Organomet. Chem., 1975, 90,C6–C8. 55 B. Fund and F. Summer, J. Org. Chem., 1982, 47, 2668– 2670. 56 Z. Shen and V. M. Dong, Angew. Chem., Int. Ed., 2009, 48, 784–786. 57 C. Hammaecher, J. Bouillon and C. Portella, Tetrahedron, 2009, 65, 5527–5534. 58 A. R. Katritzky, H. Lang, Z. Wang, Z. Zhang and H. Song, J. Org. Chem., 1995, 60, 7619–7624. 59 K. Lafaye, C. Bosset, L. Nicolas, A. Guérinot and J. Cossy, Beilstein J. Org. Chem., 2015, 11, 2223–2241. 60 D. B. Reitz, J. J. Li, M. B. Norton, E. J. Reinhard, J. T. Collins, G. D. Anderson, S. A. Gregory, C. M. Koboldt, W. E. Perkins, K. Seibert and P. C. Isakson, J. Med. Chem., 1994, 37, 3878–3881. 61 V. Gevorgyan, J. X. Liu, M. Rubin, S. Benson and Y. Yamamoto, Tetrahedron Lett., 1999, 40, 8919–8922. Research Article Organic Chemistry Frontiers 3798 |Org. Chem. Front.,2019,6,3793–3798 This journal is © the Partner Organisations 2019 Open Access Article. Published on 12 October 2019. Downloaded on 11/22/2019 7:31:28 AM. This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence. View Article Online